Julio L
@Julio_JCYL
Followers
199
Following
1K
Media
4
Statuses
198
Made in HK 🇭🇰 Current Postdoc in @SchubelerLab @FMIscience Former PhD student in @MailandLab @cphbiosciphd @UCPH_CPR
Joined August 2021
My 2nd project is out in @NatureSMB ! Following up the SUMO-RNF4 paper, from studying the replication-independent DPC repair, we identified TOPORS as a novel SUMO-targeted ubiquitin ligase, with SUMO1-binding preference. Thanks all in @MailandLab
https://t.co/hxew4aVbrw
nature.com
Nature Structural & Molecular Biology - Liu et al. reveal that human TOPORS is a SUMO1-selective SUMO-targeted ubiquitin ligase (STUbL). The parallel action of TOPORS and the STUbL RNF4 defines...
5
17
65
🚀Landmark paper out! #Chromatin context + motif grammar explain how NGN2 vs MyoD1 guide neurons🧠 vs muscle💪 from similar motifs #MachineLearning + assays uncover generalizable cooperative vs pioneer #TranscriptionFactor binding modes 📄 https://t.co/88Nwbpa3EP
3
4
13
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. https://t.co/12VxDjpwsP.
Excited to share our latest preprint. Lead by Sevi (@biosevi) we asked how transcription factors (TFs) with short and abundant motifs drive specific cell fates. Our test cases: Two bHLH factors that bind to seemingly similar E-boxes. 1/7
2
32
134
Online Now: CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance https://t.co/cWh83kNhIa
0
12
69
Vertegaal highlights recent work from Jaffray et al. ( https://t.co/F2NOyeypE5), describing how a machinery of #ubiquitin, SUMO1, & -2/3, as well as SUMO-targeted ubiquitin ligases TOPORS & RNF4, degrades the oncogene PML following arsenic treatment. https://t.co/mOqmZb9QLN
0
4
13
I feel like I'm seeing more of a basic science tilt in industry at the same time as academia is tilting more toward translation. That's okay, but keep in mind that the incentive structure of academia—high risk, long reward horizons—are conditions in which basic science thrives.
4
8
67
Another study showing the cooperating STUbL activity between RNF4 and TOPORS in a week, supporting our findings published last year! So nice to see more studies on TOPORS :)
SUMOylation/ubiquitylation of TDP-43, mediated by its recruitment to the promyelocytic leukemia protein nuclear bodies, prevents its aggregation under proteotoxic stresses https://t.co/Zkyo8742u6
0
1
1
Fresh from the oven - "PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways" very nice story from Ron's lab. happy to be able to contribute a bit :) https://t.co/g8Esf7fSSF
0
0
4
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair https://t.co/kk0f3YSqRw
0
10
39
Thank you to Shigeo Murata and Kazu Iwai for writing this heartfelt obituary for Keiji Tanaka, who played such important roles in the early characterization of the proteasome and building the vibrant protein degradation community in Japan. https://t.co/5QwOcFnTkG
cell.com
Keiji Tanaka, a beloved scientist and a pioneering leader in the field of intracellular protein degradation, passed away unexpectedly from ischemic heart disease on July 23, 2024 at the age of 75....
0
3
12
The SNSF applauds the conclusion of the negotiations with the EU. Researchers in Switzerland can participate in almost all calls for proposals in the 2025 programme year of #Horizon Europe under a transitional arrangement. ➡️ https://t.co/hPC0ULtwgh
0
29
120
🚀 #Postdoc Opportunity! 🚀 Join my lab @UniSouthDenmark in the Translational Cancer Hub initiative. Dive into cellular #senescence & its impact on cancer progression & therapy resistance! Apply here 👇 https://t.co/1qCKSZuh6T
nature.com
Three postdoc positions are available at the Department of Biochemistry and Molecular Biology, SDU under the umbrella of the translational cancer hub initiative
0
19
25
Cells turn genes on and off with the help of transcription factors, but binding to DNA is complex. @marco_heffler, @RalphSGrand and others in the @SchubelerLab found that these factors act more variably than expected, sometimes displacing nucleosomes only in certain regions 🧬
0
4
23
from Atsushi Iwama's lab Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization https://t.co/I3fofdfjAy
0
0
0
from @PimandaLab TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells https://t.co/zSYSHqwFyU
1
0
0
from @SPJacksonGroup Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS https://t.co/HGmSDyC6i7
pubmed.ncbi.nlm.nih.gov
The nucleoside analogue decitabine (or 5-aza-dC) is used to treat several haematological cancers. Upon its triphosphorylation and incorporation into DNA, 5-aza-dC induces covalent DNA methyltransfe...
1
0
0
from our lab (@MailandLab) Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation https://t.co/W0rhLP9g2Q
pubmed.ncbi.nlm.nih.gov
Protein SUMOylation provides a principal driving force for cellular stress responses, including DNA-protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using...
1
0
0
2 more papers concerning TOPORS published yesterday! 4 TOPORS papers within these few months! Very nice to see data among these papers are pretty consistent (in both fundamental and more translational science angles)! Look forwards to more TOPORS research in the near future!
【注目プレスリリース】DNAメチル化阻害剤の耐性に関わる機序を解明 ――DNAメチル化阻害剤耐性分子TOPORSを同定―― / 東京大学
1
2
4
Wouldn’t it be great to test how individual transcription factors engage with their motif in the nucleus? We tried exactly that in a study lead by Ralph (@RalphSGrand) and Marco (@marco_heffler) now out in Molecular Cell https://t.co/eZanlaaKNQ. 1/7
10
65
267
A reminder that I'm looking for a PhD student and a postdoc to study DNA repair using structural biology and single-molecule imaging. A wonderful department in a beautiful city and exciting projects ready to dive into! https://t.co/JmQsioMjuD
sites.google.com
We use biochemistry, structural biology and single-molecule imaging to understand how DNA damage is recognised, signalled and repaired. We are based in the Department of Molecular Biology and...
Join us in this adventure in beautiful Aarhus! PhD and postdoc positions available! If you're passionate about DNA repair and structural biology, we have several exciting projects for you. Please contact me for more details, and please share with your colleagues!
3
83
181
Happy to share the latest work of our lab showing the severe consequences of damage-stalled Pol II. Great work of Camila and Barbara!
academic.oup.com
Abstract. DNA damage severely impedes gene transcription by RNA polymerase II (Pol II), causing cellular dysfunction. Transcription-Coupled Nucleotide Exci
2
12
46