Julian Streit
@JulianStreit3
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Postdoctoral researcher studying protein folding and biophysics
London
Joined March 2022
New preprint with Benjamin Lang, @kriwacki, @j_christodoulou, and @m_madan_babu ! https://t.co/GTVEK9EvLe Protein Dynamics at Different Timescales Unlock Access to Hidden Post-Translational Modification Sites #bioinformatics #compchem #folding #proteindynamics
biorxiv.org
Post-translational modifications (PTMs) alter the proteome in response to intra- and extracellular signals, providing fundamental information processing in development, homeostasis and disease[1][1...
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In press!! NMR & MD simulations reveal how non-native contacts stabilise a key transient intermediate in the lysozyme amyloid cascade. @MinkooAhn @JulianStreit3 @chris_waudby @ttwlodarski @FigueiredoAm @j_christodoulou @UnivCamPharm For CMD ❤️
advanced.onlinelibrary.wiley.com
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein interme...
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Now out in @NatureComms: https://t.co/5uo7e3vfvn Rational design of fluorine NMR labelling sites to gain insights into protein structure and interactions for large complexes and in cells! #NMRchat #compchem #AlphaFold #proteinfolding
nature.com
Nature Communications - Rational design of protein labelling sites for 19F NMR experiments using AlphaFold predictions and molecular dynamics simulations enables simple, direct analyses of protein...
Happy to share our new preprint describing how #compchem can aid in 19F #NMR experimental design to study large complexes and proteins in cells - with co-first author @sammyhschan , Saifu Daya and @j_christodoulou
https://t.co/SDyXi6kLm5
#NMRchat
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Rationally designing 19F probe pairs was key to determining the structures of protein folding intermediates on the ribosome in our latest preprint. Our design strategy is now published in @NatureComms ! https://t.co/hkGEIQkKk5
#NMRchat #compchem #compbio
nature.com
Nature Communications - Rational design of protein labelling sites for 19F NMR experiments using AlphaFold predictions and molecular dynamics simulations enables simple, direct analyses of protein...
Out now! How to rationally design 19F labels to study structures of large biomol complexes, incl in cells. Using engineered ring currents, and designed with MD and AF. With co-first author @JulianStreit3, Saifu Daya & @j_christodoulou
#nmrchat #compchem
https://t.co/yGNHZSBuzA
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This work would not have been possible without the generous support from the @wellcometrust, and physics-based modelling and HPC sources @EPSRC @hecbiosim @SciTechgovuk
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Structures of protein folding intermediates on the ribosome https://t.co/cpZ6uFxaJG
#biorxiv_biophys
biorxiv.org
The ribosome biases the conformations sampled by nascent polypeptide chains along folding pathways towards biologically active states. A hallmark of the co-translational folding (coTF) of many...
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Excited to share our new preprint presenting mechanistic details of how proteins fold on the ribosome. With co-first author @sammyhschan, @ttwlodarski, Alkistis Mitropoulou, @LisaCabrita, and @j_christodoulou
https://t.co/9KNY0lst9e
#proteinfolding
biorxiv.org
The ribosome biases the conformations sampled by nascent polypeptide chains along folding pathways towards biologically active states. A hallmark of the co-translational folding (coTF) of many...
Preprint! All-atom structures of 2 folding intermediates on the ribosome, along parallel pathways & conserved across Ig domains, by 19F NMR & MD Co-led with @JulianStreit3, and thank you @ttwlodarski Alki @LisaCabrita @j_christodoulou! #nmrchat #compbio
https://t.co/HYzATjyGdX
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Visualising nascent polypeptide chains emerging from their parent ribosome with cryo-EM and all-atom MD simulations.
Cryo-EM, and integration with MD simulations, of nascent proteins on the ribosome. Congrats Alki and @ttwlodarski and co-authors!
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New preprint on the thermodynamics of co-translational protein folding!
New preprint! We find the ribosome’s electrostatic charge defines how nascent proteins fold. Using all-atom MD and 19F NMR. Led by @JulianStreit3 with @CsBurridge, Joel Wallace, @chris_waudby, @LisaCabrita @j_christodoulou
#nmrchat #compchem #compbio
https://t.co/TSYqe4KTU0
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Check out our study - NMR & MD simulations reveal how non-native contacts stabilise a key transient intermediate in the lysozyme amyloid cascade. @MinkooAhn @JulianStreit3 @chris_waudby @ttwlodarski @FigueiredoAm @j_christodoulou @UnivCamPharm For CMD ❤️
biorxiv.org
Mutational variants of human lysozyme cause a rare but fatal hereditary form of systemic amyloidosis by populating an intermediate state that self-assembles into amyloid fibrils. Despite its signif...
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Tailored NMR experiments combined with a new DNN provide high-resolution spectra of aromatic side chains and accurate uncertainty estimates - enabling quantifications of dynamics and kinetics https://t.co/3PueLfEDCv
@ScienceAdvances @gogulan_k @bhu_vaibhav @TheCrick
#NMRchat
science.org
Combining developments in deep learning and NMR opens up opportunities like high-resolution aromatic spectra from protein samples.
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Out now! How to rationally design 19F labels to study structures of large biomol complexes, incl in cells. Using engineered ring currents, and designed with MD and AF. With co-first author @JulianStreit3, Saifu Daya & @j_christodoulou
#nmrchat #compchem
https://t.co/yGNHZSBuzA
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Happy to share our new preprint describing how #compchem can aid in 19F #NMR experimental design to study large complexes and proteins in cells - with co-first author @sammyhschan , Saifu Daya and @j_christodoulou
https://t.co/SDyXi6kLm5
#NMRchat
biorxiv.org
Proteins are investigated in increasingly more complex biological systems, where 19F NMR is proving highly advantageous due to its high gyromagnetic ratio and background-free spectra. Its application...
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Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @MSFTResearch AI for Science. #ML #AI #NeuralNetworks #Biology #AI4Science
https://t.co/yzOy6tAoPv
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Meet the CALVADOS RNA model on bioRxiv or on 🦋
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Do you like CALVADOS, but also proteins with folded domains? If yes, check out Fan’s paper on the CALVADOS 3 model Several changes since the first preprint including a new parameter set and the application to changes in folding stability in condensates https://t.co/EyQ9bZ240M
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Check out the research briefing about our recent paper in @Nature. We describe how the ribosome shapes folding of its nascent proteins by integrating NMR experiments with all-atom molecular simulations: https://t.co/Cf6S7yn5G7
#NMRchat #compchem #compbio #proteinfolding #ribosome
Thrilled to share that our latest work in the Christodoulou lab is now published in Nature! https://t.co/wIFiBbUf5x Thanks to everyone who contributed @Ivana_Bukvin, @sammyhschan, @ttwlodarski, @FigueiredoAm , @chris_waudby, @LisaCabrita, @anaiscassaignau, @j_christodoulou!
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