Judy Sayers
@JudyRSayers
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Lecturer @UnivOxford | Cardiovascular researcher @GroupRiley @IdrmOxford | Alum @GurdonInstitute @TrinCollCam | Regenerative medicine, microscopy, 'omics 🫀🔬🧬
Joined December 2020
Excited to share my work @GroupRiley, out today @NatureCVR: Using imaging, scRNAseq & computational modelling , we find that the neonatal cardiac conduction system can regenerate & demonstrate how MI-induced damage elicits arrhythmogenesis 🫀⚡️. 🧵[1/n].
nature.com
Nature Cardiovascular Research - Sayers et al. reveal that heart regeneration during the neonatal period in mice extends to conduction system restoration after insult, highlighting the difference...
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Absolutely thrilled that my image was selected for the cover of NCVR this month! Link to the full issue below 🙌.
❤️Our February issue is out❤️ Discover how neonatal heart regeneration extends to the conduction system, a new kinase controlling atherosclerotic plaque development, vascular smooth muscle cell phenotypic switching in aneurysms, and more!.
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Finally, there's a great N&V article by @MiaoCui_713 to accompany the paper that can be found here: [end].
nature.com
Nature Cardiovascular Research - Myocardial infarction can lead to arrythmias, which increase mortality, but the mechanisms behind this are unclear. A study shows that the capacity to regenerate...
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We couldn't have done this work without lots of support, including from @Oxford_MRC_DTP @TheBHF @IdrmOxford @OxfordDPAG @OxfordMedSci [8/n].
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This was a huge effort with fantastic collaborators & colleagues - many many thanks to Paul @GroupRiley, @HectorMtnezNav, @neutrinonstrike, @clcortex, @saukaspengler and all those not on twitter 🙏🙏! [7/n].
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Finally, modelling the non-regenerative phenotype from the day 7 mouse in the infarcted human heart implicated these changes as causative for heart block 🖥️[6/n].
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ScRNAseq revealed the molecular changes underpinning conduction restoration in neonatal hearts, vs sustained aberrant electrical alterations during fibrotic repair that also manifested via ECG 🧬⚡️[5/n].
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By tissue clearing neonatal hearts and performing whole organ imaging, we discovered global His-Purkinje disruption and disorganisation of conduction fibre bundling 🔬[4/n].
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We found that the conduction system restores during neonatal mouse heart regeneration, whereas it undergoes pathological remodeling at non-regenerative stages 🩹❤️🩹🫀 [3/n].
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Though arrhythmias are a hallmark of MI, how damage to the conduction system affects arrhythmia is poorly understood - so we decided to explore the impact of MI on the conduction system during heart regeneration and fibrotic repair. [2/n].
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RT @MSTO89197800: Feeling festive! Happy to share our new bioRxiv pre-print - investigating the role of calcium in the early embryo (with a….
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RT @maxewilkinson: How do LINE family retrotransposons jump around?.Can we reprogram retrotransposons?.What does this have to do with Rum a….
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RT @EricTopol: New @Nature.Bridge RNA: a big discovery form nature that adds to power and precision of genome editing for long DNA sequence….
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RT @ArlottaLab: Finally out @Nature! “Chimeroids” as powerful avatars of the human Brain can recapitulate unique features and responses of….
nature.com
Nature - An analysis in 3D multidonor Chimeroids—a scalable multidonor human brain organoid model—shows that human genetic background may be an important mediator of neurotoxin...
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RT @IdrmOxford: Happy International Women's Day!.Join us in celebrating the amazing and accomplished women of the IDRM, with a particular n….
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Officially a Dr now 🎓!!. What a privilege to have finished my DPhil after 4 wonderful years with colleagues and friends @GroupRiley @IdrmOxford @OxfordDPAG @UnivOxford. A huge thank you to my excellent examiners for such a stimulating discussion! . #PhDone #phdlife #DPhinished.
Massive congratulations to @JudyRSayers for completing her DPhil! She has taken the world of the cardiac conduction system by storm and a bright future lies ahead! Many thanks to Prof. Thomas Braun @mpi_hlr and @Choudhury_Lab for the excellent discussions. @IdrmOxford @UnivOxford
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RT @YanlanMao: Interested in #Biophysics but unsure if you want to do a PhD? Apply to our new #MRes on #Computational Cell Biophysics. Plea….
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RT @Dev_Cell: Online now: Distinct epicardial gene regulatory programs drive development and regeneration of the zebrafish heart https://t.….
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RT @clcortex: 🚨 Meeting alert! 🚨. Do you study cell lineages? Development, cancer, growth, regeneration? . Join our @royalsociety meeting “….
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