High-intensity statins lower LDL cholesterol in high-risk ASCVD patients, but combining moderate-intensity statins with ezetimibe offers similar benefits with a lower risk of new-onset diabetes and statin intolerance. https://t.co/p0OrAKjTEC @CardioSSoon

Another point of confusion with respect to Lp(a) particles is that the size [molecular weight of apoprotein (a)] has no relationship to the size (diameter) of the LDL moiety of the Lp(a) particle. Small LDLs refers to particle diameter of the LDL and small Lp(a) refers to the

News from @Novartis Readout for HORIZON Ph3 cardiovascular outcomes trial testing pelacarsen - ASO targeting Lipoprotein(a) now *2026* (earlier guidance had been 2025) An event driven trial and event rate seems lower than initially projected https://t.co/cQq3FkWYKZ

Various subsequent studies and analyses have disproved this idea that the MMR vaccine causes autism (see Taylor et al. 1999). Below is a great article explaining the issues with the original study and highlighting what the evidence actually shows. https://t.co/RjC280Vz55.

For anyone actually buying into anti-vaccine nonsense, the MMR vaccine does NOT cause autism. Just want to make sure we’re clear on that. The “evidence” for that claim came from a 1998 paper by Andrew Wakefield et al. The poorly designed, fraudulent study was later retracted.

A meta-analysis is only as good as what you put in the blender — mix in fluff, and the results fall flat.

Lipoprotein, Lp(a) and LDL-cholesterol, LDL-C, are independent and additive for cardiovascular risk. Reduction in LDL-C cannot fully offset Lp(a)-mediated risk suggesting a need for targeted therapy for both. @PeterWilleit @hsbhatia @Lpa_doc https://t.co/fca9v6Ksoi

I don’t care if he “isn’t going to take away anyone’s vaccines” (which also remains to be seen). Spreading the sentiment is doing plenty of damage. People trust him and he may end up in a position to do a lot of good…or he may end up bringing back various eradicated diseases.

I don’t know anyone who would disagree with @RobertKennedyJr on Americans needing to be healthier. Tons of our food is garbage and has plenty of room for improvement. But spreading anti-vaccine sentiments from a position of authority is harmful and irresponsible.

Highly encourage people to check out costplusdrugs. Its saved my patients a LOT of $$. Plus no prior auths!

Finally finished up the ~11 hours of episodes of @theproof with @Drlipid. Easily the best resource for an in depth intro to lipidology and probably my favorite podcast series I’ve come across. Can’t recommend it highly enough.

Instead of appeals to mechanisms, let's look at the outcome data: 1⃣ WOSCOPS (Primary Prevention with Pravastatin) HR=0.87, 95% CI 0.80-0.94,P=0.0007. 2⃣ MEGA trial (primary prevention with Pravastatin in Japanese): HR 0.67, 95% СІ 0.49-0.91; р=0.01. 3⃣ JUPITER (primary

More data on the way with the newest CETP inhibitor - obicetrapib!

Regardless of who you voted for, I hope science prevails when it comes to public health. We do need to improve our food environment. We do want people to be more physically active. We still need to prevent communicable disease through proper vaccination.

The MAHA movement is using nutrition and exercise (which are awesome) as a Trojan horse to promote nonsense: - removing fluoride from water - promoting ineffective therapies (ivermectin for covid etc) - various anti-vax rhetoric We all agree our food environment needs changing.

This is an interesting issue and I see this in my Lp(a) Clinic almost each time I have it. In general, there is more benefit to continuing than stopping stain. However, if I can achieve low LDL-C by non-statin means and not increase Lp(a), for now, that seems like a good

Please don’t take Red Yeast Rice (RYR) supplements. The active ingredient in RYR is literally a statin (lovastatin). Either don’t take it at all, or take a prescription statin with a known/consistent dose, purity, etc.

Lp(a) is an independent risk factor, so no other risk factor being low negates its risk, but may modify overall risk. It's true for apoB also, see below where adjusting for apoB does not affect Lp(a) mediated risk. ApoB is a very small component of Lp(a), in general <5-10%, and

Lipidaholics - Much of my career has been in the lipid aspects of preventive Cardiology - I implore you to listen to @theproof where Simon Hill interviews the one and only first Fellowship-trained Neurologist, my friend and colleague Dr Kellyann Niotis. So many of us are

I just finished all ~9 hours of Dr Dayspring’s (@Drlipid) appearances on @PeterAttiaMD podcast, and I can’t recommend them highly enough. Eye opening to dive so much deeper than I knew possible on a topic I *thought* I knew quite well!