Denu Lab
@JohnDenuLab
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@BMC_UW #epigenetics lab | Focused on mechanisms and biological function of reversible protein modifications #chromatindynamics #metabolism #microbes 🧪🧫🧬🔬🦠
Madison, WI
Joined April 2020
Excited for our newest publication about how the intrinsic kinetics of H3K9 HMTs maintain H3K9me1 under low SAM levels! Great work, @SpencerHaws, @lilymiller88, and Slava! Check it out! .
jbc.org
S-adenosylmethionine (SAM) is the methyl donor for site-specific methylation reactions on histone proteins, imparting key epigenetic information. During SAM-depleted conditions that can arise from...
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Congratulations, Zena! 🧬🧫🎉.
Wishing all the best to Zena Jensvold who defends her thesis next Monday, July 31! 🎉
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Great work, @LauraSteenberge and @Pagliarini_Lab! 🧫🧪👩🏼🔬.
CoQ10 is large and very hydrophobic, which limits its bioavailability. Our new study, led by @LauraSteenberge, shows that CoQ4 is a sufficient substitute for multiple CoQ functions in cells and can be targeted to mitochondria. #bioRxiv .#mitochondria .#CoQ.
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Check out our newest publication in @jbiolchem in press this week titled "Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-methionine"!.
Have you checked out our newest articles in press this week? Here you go! You can also get them sent straight to your inbox. Register for email alerts here:
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@SpencerHaws @lilymiller88 Thank you to our collaborators, Diego Rojas La Luz, Gheorghe Craciun, and Ray Trievel!.
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RT @biorxivpreprint: Fluorogenic Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7 #….
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So jazzed about this preprint! There is so much to learn about SIRT7 with this new fluorogenic assay! ✨.
New preprint on @bioRxiv.In collaboration with @JosephRogers100, @JohnDenuLab, and #PernilleHarris lab, we developed an in vitro assay for evaluation of SIRT7 modulators, performed #SAXS studies, and discovered cyclopeptide inhibitors, using #RaPID.
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Jazzed to hear about the culmination of Caleb's thesis work tomorrow! 🧫🧬.
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Congratulations, Zhangli! 🎉 Can't wait to see what your lab accomplishes! 🧪🧫🧬.
A personal update while working on #RNA23 badge. Excited to announce that Su Lab will open its door @UABGenetics in July! We are recruiting at all levels for anyone who is interested in RNA modifications, gene regulation, NGS analysis and cancer biology. (1/4)
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Stop by Lily's seminar to hear about her thesis work investigating the catalytic mechanisms of epigenetic enzymes! 🧬🧫🧪📈🧵.
IPiB seminar this week will be given by Lily Miller (@lilymiller88) from the Denu Lab (@JohnDenuLab). More info:
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Our newest member of the Denu Lab Pragyan Mishra completed her external reviewer PhD defense in Infection Epigenetics from KIIT today! Congratulations, Dr. Mishra!! We're so happy to have you in our lab! 🧬🦠🎉.
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Great job presenting your studies about how diet can affect host epigenetics and Alzheimer's! 🍽️🦠🧫🧬.
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Always jazzed to talk about how metabolism and epigenetics are intertwined. Thanks, EpiCypher!.
Yesterday we were pleased to host @JohnDenulab for a lively discussion of his lab's latest research on how the #epigenome responds to metabolic stress. Thank you for visiting and being a part of our continuing education series at EpiCypher!
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Congrats, @briansmithlab!.
We're excited for our PBRM1 bromodomain inhibitor work to be featured in @PracticalFrag! A nice example of our @mcwchembio fragment screening pipeline. Thanks to @EmilyDykhuizen for cell work. @MedicalCollege @MCW_Research.
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So saddened to hear about the passing of C. David Allis. Wonderful work done in the chromatin field and more importantly, such a wonderful colleague. You will be missed.
It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.
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Such a great resource!.
Just updated and expanded: our massive database of postdoctoral fellowships. These are all fellowships NOT attached to any specific university. We include description, $ amount, deadline, field, and eligibility criteria. Download it here:
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Happy International Day of People with Disabilities! And thanks to the @Hull_Lab for always keeping us up-to-date with these important days!.
Happy International Day of People with Disabilities!!! This year, the theme is ‘Not All Disabilities are Visible’. We must all work hard to make things inclusive and accessible to all, even if we cannot their differences.
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🧬🧪🍻.
If you are in a @uwgenetics or @uwmadisonipib lab come join us for a social lunch tomorrow in BSB Atrium. We'll have food, dope people doing dope science, and good vibes!
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Jazzed to co-host @PospisilikJ for today's inaugural Jim and Katie Krause Metabolism Seminar! Come join us for an awesome seminar at 3pm!
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