Joseph E. Peters
@JoePetersLab
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Professor and Chair, Dept Microbiology Cornell Ithaca. Interested in genome evolution and mobile DNA, especially Tn7 and CRISPR-Cas transposition systems
Ithaca, NY
Joined October 2017
It was a pleasure working with @PopoMicro on this review of CRISPR-Cas associated transposons (CAST). Hopefully it gives a sense for the diversity of Tn7-like transposons and CRISPR systems that independently combined. https://t.co/Aq8lz2HG3O
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In addition to a highly collaborative lab environment we interact with a dynamic Microbiology community, DNA Replication, Recombination and Repair group and a growing list of transposon-centered lab https://t.co/YrNhnqGqt0
cals.cornell.edu
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The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition
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Functional RNA splitting drove the evolutionary emergence of type V CR...
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Here is a link to a new preprint from the lab, a collaborative effort between our lab and Michelle Wang's lab here at Cornell. https://t.co/XZewmW00hc
biorxiv.org
Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair...
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De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems
biorxiv.org
Programmable DNA integration using CRISPR-associated transposons (CASTs) offers powerful capabilities for genome engineering. The single effector Cas12k CAST examples evolved from a fixed guide TnpB...
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A family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial species https://t.co/FfmJGi9NGC
#biorxiv_micrbio
biorxiv.org
Temperate phages oscillate between lysogeny, a genomic maintenance state within a bacterial host, and lytic replication, in which the host is killed, and newly made phage particles are released....
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Tn7 family transposons that include all guide RNA-directed transposons (CAST) are common in bacteria. We now find diverse representatives across archaea, many in the Asgard group. Reviving an Asgard element confirmed the exciting behaviors of the family
biorxiv.org
Tn7 family elements are DNA transposons in bacteria that show tight control of targeting, including multiple varieties that evolved guide RNA-directed transposition. We find diverse Tn7 elements...
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Note: there is a free-access reprint-link on our lab publications page
cals.cornell.edu
RD Schargel, L Chacon Machado, S Kumaran, JE Thesier, A Guarné and JE Peters (2025) De novo guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems....
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@JoePetersLab Very cool story lead by @JoePetersLab reveals another level of how transposons battle with their hosts. Grateful to have had a chance to participate with Popo @PopoMicro, Joe and the team!
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A thread from the Postdoc who led the work on bacterial Telomeric transposons. A wonderful collaboration with the Barabas lab. Officially out in the journal today!
In eukaryotes, some transposons target telomeres; in Drosophila, they even replace them. Peters lab and Barabas group show that bacteria with linear genomes also harbor diverse telomeric transposons. https://t.co/QxXMlJaenE
@JoePetersLab @BarabasGroup
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Transposons, or “jumping genes” – DNA segments that can move from one part of the genome to another – are key to bacterial evolution and the development of antibiotic resistance. Cornell researchers have discovered a new mechanism these genes use to survive and propagate in
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Note: there is a free-access reprint-link on our lab publications page
cals.cornell.edu
RD Schargel, L Chacon Machado, S Kumaran, JE Thesier, A Guarné and JE Peters (2025) De novo guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems....
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Note: there is a free-access reprint-link on our lab publications page
cals.cornell.edu
RD Schargel, L Chacon Machado, S Kumaran, JE Thesier, A Guarné and JE Peters (2025) De novo guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems....
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Researchers @CornellCALS and colleagues have discovered a new method that “jumping genes,” or transposons, use to survive and propagate in bacteria with linear DNA, with applications in biotechnology and drug development. @ScienceMagazine @JoePetersLab
news.cornell.edu
Researchers identified several families of "jumping genes," or transposons, in cyanobacteria and Streptomyces that can find and insert themselves at the telomere, with benefits for the transposon and...
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Telomeric transposons are pervasive in linear bacterial genomes | Science
science.org
Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric...
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Our preprint is now published
science.org
Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric...
Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear genomes. We identified several families of independently evolved telomeric transposons. 1/7
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🧬 Thrilled to share our latest research on Retrons—a new chapter in this fascinating field! 🌟In this @MolecularCell paper, we reveal how Retron-Eco1 defends against phages. https://t.co/w0xaPayTCr Check the 🧵below! (1/20)
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#CRISPR revolutionized medicine, but where did its RNA-guided mechanisms come from? Using #AI, we unearthed new Cas13s and found they evolved from toxin-antitoxins, revealing how nature created these amazing reprogrammable molecules. Discover the recipe: https://t.co/nUws6DpNhD
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Very excited about this work from graduate student Laura Chacon Machado now published in Mobile DNA, “A family of Tn7-like transposons evolved to target CRISPR repeats”!
Our preprint describing a family of Tn7-like transposons that evolved to target CRISPR repeats is now published at Mobile DNA #Tn7 #transposons #mobileDNA 1/10 https://t.co/nkMS5cslyY
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📢 Prof. Marcin Nowotny has received the Prime Minister’s Award! The prize honors his research on protein-nucleic acid interactions, advancing our understanding of cellular information decoding. 👉 Read more: https://t.co/grWqpIYmai
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