Sarah Jäkel
@JekyllSarah
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Neuroscientist, oligodendrocyte lover, Emmy-Noether fellow, mum
Munich, Bavaria
Joined December 2017
Working part time as a parent in certain positions is probably the biggest scam. You are still expected to do the same amount of work in less time for less money.
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Really emjoyed our session yesterday afternoon at #GLIA2025 on oligodendrocytes with @LuiseASeeker @GoCasteloBranco and others. We had a brilliant discussion aftwrwards. The glia community is always great!
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Excited 2 be in Marseille for our symposium on understanding human oligodendroglia: a lifespan perspective at #GLIA2025. Join the brilliant @GoCasteloBranco, Sarah Jäkel, Nina Kazakou, Sunniva Bøstrand and myself. We are presenting exciting human data generated with @10xGenomics.
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Hurler et al. report that fixation times affect mRNA detection in post-mortem human brain tissue, highlighting the need for standardised protocols to ensure reliable and comparable results in mRNA studies. Read at: https://t.co/CNLgZO2atg
@JekyllSarah #mRNA #neuroscience
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https://t.co/1L41WUvNEE Our paper is now out in GLIA! Excellent work led by @vidramesh and supported by @sidb_edinburgh. Thank you to everyone involved, especially to @e_tsou @Ioannakougianou @odando @Zrile
onlinelibrary.wiley.com
Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP-deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in...
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Our new pipeline is out! In this work we detail an ex vivo versatile platform for assessing myelin dynamics of hiPSC oligodendroglia. 🔗 Check it out @STARProtocols: https://t.co/75NrNN5WqO Huge thanks to my mentor @ErinMGibson and collaborators @LidaZoupi and @AnnaWilliamsLab!
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Today marks a special day in my career - I received the official document that as of February, I will be a professor at TU in Munich. There are certainly many people who supported me all along the way to achieve this goal. I am really looking forward to the next steps.
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So happy to be involved in this project. Very important work linking amyloid and tau pathology. https://t.co/Fi9H6QErnD
science.org
Aβ induces neuronal hyperconnectivity, which promotes tau spreading from temporal lobe epicenters to connected brain regions in Alzheimer’s disease.
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Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article together with @burbulla_lab - and be certain that this topic is just at the beginning of being explored! https://t.co/vAnvJkNmtl
journals.plos.org
The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic...
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Neuroinflammation in Alzheimer disease: I feel very privileged to have contributed to this excellent review led by Prof. @michael_heneka together with other leading experts in the field. https://t.co/pEgCL0EAwu
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So glad to see this work finally out. A huge collaborative effort, and besides the biological findings, also a brilliant resource. https://t.co/D41eacbb9G
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Positive #MS research news just before Christmas! A team co-led by @AnnaWilliamsLab has published gene expression findings from post-mortem samples that separate MS brain samples into 4 groups. Paves the way for personalised treatments. More at https://t.co/Dx0SBSsngN
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The first paper of the Jäkel lab is published! Are you working with post-mortem brain tissue and want to detect RNA in FFPE tissue? Then you should consider the fixation time before your experiment. Nice collaboration with @liebscher_lab
https://t.co/k1Cul6jhqs
academic.oup.com
Hurler et al. performed RNAscope on post-mortem human brain tissue and found mRNA signal detection to be highly dependent on fixation time. Considering the
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It was a great pleasure to host Goncalo Castelo-Branco @GoCasteloBranco today at our TRR274 seminar today. Lots of interesting techniques and data!
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Interested in what happens with glia in Huntington's disease? Check out this new publication.
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Check out this fantastic work from @LenaSpieth @StefanBerghoff and others! A new role for microglia and APOE in plaque seeding in AD. And I am glad I was able to help a bit.
🚨NEW PAPER ALERT 🚨 Our paper just got published in @ImmunityCP ! From Munich with 🥨 Check it out here: https://t.co/CSmlm3EJ0r
@Seiji_Kaji, @StefanBerghoff, Mikael Simons #apoe #Alzheimers #microglia 1/9
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Early Career Researchers (ECRs) are the future of MS Research. Professor Anna Williams tells us 7 things we should know about ECRs and how important it is to support their innovative work. ➡️ MS HISTORY MAKERS: https://t.co/OvS13gtQrK
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I currently feel that!
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The newly launched journal "Glial Health Research" would be excited to receive your manuscripts! publication fees are fully waived until April 2026!
Hi glia folks! A new exciting journal will be launched soon and we are looking for submissions relevant to all aspects of glia.
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We are delighted to announce our scientific programme for #glia2025! Get to know our fantastic plenary speakers https://t.co/e0vgIAqzZt and have a look at next year's symposia and workshops https://t.co/0dRVV2dxaP We cannot wait to welcome the #gliacommunity in #Marseille!
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