Jan Korbel
@JanKorbel5
Followers
662
Following
6
Media
0
Statuses
50
Life & data science researcher at EMBL Heidelberg, Germany
Joined April 2019
Today our editorial on the impact of the COVID-19 crisis on life scientists was published. A huge thanks to our colleagues for contributing to the survey we conducted on the impact of COVID-19 on the daily work of biologists. @OliverStegle @KorbelGroup.
genomebiology.biomedcentral.com
1
30
56
RT @isidrolauscher: Finally, very excited to have contributed with Sonia Zumalave at @emblebi to the following study led by @JanKorbel5 pre….
biorxiv.org
Chromosomal instability results in widespread structural and numerical chromosomal abnormalities (CAs) during cancer evolution[1][1]–[3][2]. While CAs have been linked to mitotic errors resulting in...
0
3
0
An intriguing, comprehensive analysis of retrotranspositions in cancer genomes using long reads by the Tubio and Rodriguez-Martin labs, revealing the frequent occurrence of retrotransposon-mediated rearrangements in cancer
biorxiv.org
L1 retrotransposition is a significant source of genomic variation in human epithelial tumours, which can contribute to tumorigenesis. However, fundamental questions about the causes and consequences...
1
0
3
To clarify, a companion manuscript ( to our study ( used our long-read dataset for imputation and genome-wide association studies. Collectively, both studies show how long-reads can be leveraged for broad scientific applications.
biorxiv.org
Structural variants (SVs) contribute significantly to human genetic diversity and disease[1][1]–[4][2]. Previously, SVs have remained incompletely resolved by population genomics, with short-read...
0
5
27
RT @tobiasmarschal: Thrilled to announce the largest long-read based SV resource on open samples (1kGP) to date. Highlights include a pange….
0
32
0
RT @ewanbirney: So proud of @embl to have won the German AI prize - congratulations to all my colleagues across @embl who contributed to th….
0
7
0
RT @biorxivpreprint: Cell type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells https://t.co….
0
2
0
RT @EMBLHeidelberg: Congratulations to our EMBL Heidelberg labs that received @LEAFinLabs awards! And a huge thank you to everyone who made….
0
4
0
Our work on the scNOVA single cell method has now been published in Nature Biotechnology. This Strand-seq based computational method combines nucleosome occupancy and SV analysis to determine the effects of somatic structural variants in leukaemia.
nature.com
Nature Biotechnology - Linking structural variants to gene expression information identifies aberrant signaling pathways.
0
31
100
RT @NatureBiotech: Functional analysis of structural variants in single cells using Strand-seq .
0
33
0
EMBL’s Data Science Centre is growing - become a part of it!.EMBL is looking for a Team Leader in Bioimage Analysis - apply here:.
0
1
6
Happy birthday AlphaFold Database, on the day Gregor Mendel would have celebrated his 200th birthday. #AlphaFold enabled fantastic scientific achievement over the course of this last year!.
AlphaFold DB marks its one year anniversary 🎉. To celebrate we look back at some of the exceptional advancements that #AlphaFold has made possible over the last 12 months and we invite you to add your own work in the replies. @DeepMind . Comment below👇
0
0
10
We are hiring postdocs! Reach out if you are keen to work in single cell and long-read genomics, computational biology, or image analysis, to study patterns of mosaicism! Our interdisciplinary are, depending on interests, geared more towards experimental or data science research.
4
46
119
Read our current paper on recurrent inversion polymorphisms and genomic disorders, based on a great collaboration with the Eichler and Marschall labs
cell.com
Large-scale analysis of haplotype-resolved inversions in human genomes unveils recurrent inversion polymorphisms and their disease relevance.
0
2
16
RT @CodeDesLebens: Juhu, heute ist es endlich soweit. Die erste Folge des GHGA #Wissenschaftspodcasts ist live. Wir sind schon sehr gespann….
ghga.de
Der Code des Lebens – der Wissenschaftspodcast von GHGA beschäftigt sich mit verschiedenen Aspekten der menschliche Genomforschung. Wie ist unser Erbgut entstanden? Wie funktioniert Genomforschung...
0
4
0
RT @mjbonder: Interested in the application of long read technology on a cancer genomics?.Read our pre-print on the application of ONT sequ….
0
26
0
A new era for European molecular biology via @embl.
embl.org
EMBL announces details about its next programme, 'Molecules to Ecosystems', studying life across scales and in context with its environment.
0
4
15
Haplotype-resolved inversion landscape reveals hotspots of mutational recurrence associated with genomic disorders
biorxiv.org
Unlike copy number variants (CNVs), inversions remain an underexplored genetic variation class. By integrating multiple genomic technologies, we discover 729 inversions in 41 human genomes. Approxi...
0
4
12
Haplotype-aware single-cell multiomics uncovers functional effects of somatic structural variation
biorxiv.org
Somatic structural variants (SVs) are widespread in cancer genomes, however, their impact on tumorigenesis and intra-tumour heterogeneity is incompletely understood, since methods to functionally...
0
5
37
RT @syedkashifsadiq: Delighted to present AlphaDesign, a computational tool for #SyntheticBiology that builds on #AlphaFold to design nove….
biorxiv.org
De novo protein design is a longstanding fundamental goal of synthetic biology, but has been hindered by the difficulty in reliable prediction of accurate high-resolution protein structures from...
0
30
0
RT @Gemma_Lass: The incredible @Deepmind #AlphaFold protein structure predictions for the human proteome and 20 other model organisms are….
0
4
0