Giessen Lab
@GiessenLab
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Structure, function, and engineering of protein assemblies @UMich. Microbial Biochemistry | Cryo-EM | SynBio | Encapsulins | Natural Products | Enzyme Filaments
Ann Arbor
Joined February 2020
New paper out @NatureComms. Tremendous work by postdoc Mike Andreas, congrats!
nature.com
Nature Communications - The volatile odorant 2- methylisoborneol is one of the most abundant terpenoid natural products found in nature. Here, the authors report biochemical and structural data...
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New review out @ChemBioChem. Learn all about encapsulin shells!
chemistry-europe.onlinelibrary.wiley.com
Encapsulin nanocompartments are one of the most diverse and widespread classes of prokaryotic protein compartments. This review focuses on the structural diversity of encapsulins with a focus on...
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New paper out at @acsnano. Awesome work by PhD student Seokmu Kwon (@smkwon6) and postdoc Mike Andreas!
pubs.acs.org
Enzyme nanoreactors are nanoscale compartments consisting of encapsulated enzymes and a selectively permeable barrier. Sequestration and colocalization of enzymes can increase catalytic activity,...
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Recent paper out at Protein Science (@ProteinSociety). Congrats to now graduated PhD student Robert Benisch (@robertbe_)!
onlinelibrary.wiley.com
Rhodanese-like domains (RLDs) represent a widespread protein family canonically involved in sulfur transfer reactions between diverse donor and acceptor molecules. RLDs mediate these transsulfurati...
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New preprint out @biorxivpreprint. Great work by PhD student Seokmu Kwon (@smkwon6) and postdoc Mike Andreas. Congrats! https://t.co/RqpdsLPsfp
biorxiv.org
Enzyme nanoreactors are nanoscale compartments consisting of encapsulated enzymes and a selectively permeable barrier. Sequestration and co-localization of enzymes can increase catalytic activity,...
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New preprint out @biorxivpreprint. First two-component encapsulin system. Incredibly complex assembly. Congrats to PhD student Cassie Dutcher and postdoc Mike Andreas! https://t.co/ToJM6sXKGN
biorxiv.org
Protein shells or capsids are a widespread form of compartmentalization in nature. Viruses use protein capsids to protect and transport their genomes while many cellular organisms use protein shells...
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New preprint out @biorxivpreprint. First structure of a Family 2B encapsulin. Congrats to postdoc Mike Andreas! https://t.co/IFEXlpid2o
biorxiv.org
Terpenoids are the largest class of natural products, found across all domains of life. One of the most abundant bacterial terpenoids is the volatile odorant 2-methylisoborneol (2-MIB), partially...
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New paper out @NatureComms. Congrats to postdoc Mike Andreas, great work! https://t.co/dXBobHvDQf
nature.com
Nature Communications - Many cyclic dipeptide natural products can be modified by cyclodipeptide oxidase enzymes. Here, the authors report the structural characterization of the cyclodipeptide...
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New paper out @NatureComms. Congrats to postdocs Jesse Jones (now faculty at Idaho State) and Mike Andreas! https://t.co/w3wtRC3Juw
nature.com
Nature Communications - Peroxidase encapsulins are self-assembling protein compartments involved in oxidative stress response found in many pathogens. Here, the authors characterize the structural...
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New publication from the lab. Congrats to PhD student @robertbe_ and postdoc Mike Andreas. Great work! https://t.co/cVntiJJXVd
science.org
An encapsulin protein compartment sequesters and stores elemental sulfur.
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Postdoctoral Research Fellow positions in cryo-EM | microbial biochemistry | protein engineering | natural product sciences available in our lab!
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1/ We’re excited to share our work on HIV-1 trafficking by dynein! Led by the amazing @badieyan in the lab with wonderful collaborations with @EdcampbellLab, @GiessenLab, Aiken Lab, Böcking Lab, and @morgan_desantis. TL;DR HIV-1 hijacks the dynein motor protein for motility 🧵
HIV-1 binds dynein directly to hijack microtubule transport machinery https://t.co/RzYZw7ePXS
#bioRxiv
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Happy to have this paper published in @ACSSynBio
https://t.co/1lHlV3daB9 Congrats to my student @smkwon6
pubs.acs.org
Protein nanocages have emerged as an important engineering platform for biotechnological and biomedical applications. Among naturally occurring protein cages, encapsulin nanocompartments have...
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Come join our faculty @UMich in beautiful Ann Arbor! Learn more and apply at https://t.co/tNnwYgo6S1
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New preprint is out on @biorxivpreprint: https://t.co/JA4SozUfIJ We characterize a highly acid-stable and dynamic encapsulin nanocage exhibiting pH-dependent all 'open' or all 'closed' pore states. #encapsulin #nanocage
biorxiv.org
Encapsulins are microbial protein nanocages capable of efficient self-assembly and cargo enzyme encapsulation. Due to their favorable properties, including high thermostability, protease resistance,...
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New preprint is out on @biorxivpreprint: https://t.co/o2ebWyQBr6 We engineer novel nanocages to package RNA and protein in vivo at the same time for future drug co-delivery applications. Congrats to my student @smkwon6
#RNA #drugdelivery #encapsulin #nanocage
biorxiv.org
Protein nanocages have emerged as an important engineering platform for biotechnological and biomedical applications. Among naturally occurring protein cages, encapsulin nanocompartments have...
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Thanks to @GiessenLab and Prof Schiller @FRIAS_UFreiburg for the external examination
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Happy that our review on the structure, function, and basic biology of encapsulins is now available @AnnualReviews of Biochemistry: https://t.co/MqMGkkeyax
#encapsulin #nanocompartment #stressresistance #naturalproducts
annualreviews.org
Subcellular compartmentalization is a defining feature of all cells. In prokaryotes, compartmentalization is generally achieved via protein-based strategies. The two main classes of microbial protein...
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Our study on pore structure and molecular flux into #encapsulin nanocompartments with @GiessenLab is now in shiny typeset format in @ScienceAdvances
https://t.co/BlOLZQcF70 Congrats @nurentasneem, Lachlan, Regi, @taylorszyszka and Eric @MyxXanthus from our lab, and... 🧵
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Really happy to have played a part in this fascinating look into encapsulin pore structure and porosity lead by @YuHengLau and @GiessenLab with @MeganLOMara
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