Felix Frey
@sciFelixFrey
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Theoretical biophysicist | Postdoc with @SaricLab at @ISTAustria
Vienna, Austria
Joined March 2020
đź“Ł Paper alert đź“Ł
Interested in #clathrin? Our new paper with @sciFelixFrey on the cooperative curvature model for clathrin-mediated endocytosis is now out in Physical Review E: https://t.co/gvTBY1MjkE Here a short thread to explain the main ideas ... (1/5)
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Did you know there are more than bilayer #membranes in nature? Meet the #archaeal monolayer and its surprising mechanical properties! New #preprint! (1/7)
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In this study led by Lucia Baldauf we established a robust method to reconstitute vesicles with an actin cortex and – by pairing with theory by @sciFelixFrey and @TimonIdema - discovered that branched actin preferentially assembles at membrane necks!
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Now out in @JCellBiol: the geometry of clathrin coats measured with superresolution microscopy as function of pseudotime by @markus_sci, @aline_tschanz and @yule_wu from @JonasRies lab at @EMBLHeidelberg. Excellent agreement with cooperative curvature model by @sciFelixFrey
Very excited that part of my PhD work is now published in JCB! Together with @markus_sci, we investigated the nanoscale remodeling of clathrin coats during endocytosis using superresolution microscopy.
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Very excited that part of my PhD work is now published in JCB! Together with @markus_sci, we investigated the nanoscale remodeling of clathrin coats during endocytosis using superresolution microscopy.
Want to learn more about the remodeling of the endocytic #clathrin coat in mammalian cells? @markus_sci & @aline_tschanz et al. @JonasRies lab @embl use superresolution #microscopy and computational modeling to investigate this mechanism at the nanoscale. https://t.co/llkmBmF8Yw
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The NOMIS foundation and @ISTAustria present three exciting new fellowships, raising the count of NOMIS fellows on our campus from four to seven. đź”—
ista.ac.at
This autumn, three new post-doctoral fellows have begun their scientific pursuits at multiple labs at the Institute of Science and Technology Austria (ISTA), raising the count of NOMIS fellows on...
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@istaustria experienced increased #cyberattacks lately, which could initially be repelled. After the attacks intensified today, the Institute took all #servers offline, incl e-mail & homepage. Origin and aim are investigated further together with external support.
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@sciFelixFrey's paper on the relation between membrane area growth and cell division published in @PhysRevE:
journals.aps.org
In cytokinesis of animal cells, the cell is symmetrically divided into two. Since the cell's volume is conserved, the projected area has to increase to allow for the change of shape. Here we aim to...
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Very excited that this story is out fresh on bioRxiv! We used superresolution microscopy to understand how the clathrin coat forms during endocytosis - a 🧵 with pretty pictures and a cool mechanism! 1/9 https://t.co/8fLmsMzpaA
biorxiv.org
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular cargos. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains controversial...
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Tomorrow (23/03) at 4:00 pm I will present a poster at #DPG2021 #BPCPPDYSOE21 on work dating back to my PhD together with @SchwarzUlrich. Join BP 24.14 if you like to know why we think that flat clathrin lattices assemble with lattice vacancies.
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What can be learned about internal cellular processes by modeling membrane shape? Our new review together with @TimonIdema is now available in @softmatter
pubs.rsc.org
The correct execution of many cellular processes, such as division and motility, requires the cell to adopt a specific shape. Physically, these shapes are determined by the interplay of the plasma...
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Which physical mechanisms can drive membrane bending during clathrin-mediated endocytosis ? From a continuum point of view, there are three of them, which we now analysed in one unifying and analytical theory. New work with @FelixFrey12 out in Soft Matter
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We use the Eden model to simulate the growth of flat clathrin lattices and compare it to EM data. Our new paper together with @SchwarzUlrich, @BoulantLab, @kem_sochacki and @taraskalab is now available in @NJPhysics . https://t.co/ODDrucurKk…
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We developed a new computational model to address the amazing plasticity of nonmuscle myosin II minifilaments and in particular the roles of the different isoforms. Great work by Tom Kaufmann now out in @PLOSCompBiol
journals.plos.org
Author summary Nonmuscle myosin II (NM2) is a non-processive molecular motor that assembles into minifilaments with a typical size of 300 nm to generate force and motion in the actin cytoskeleton....
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Duco's and Gerhard's work on defect dynamics in developing bacterial colonies (collaboration with Tans lab @_amolf) is finally available as a preprint https://t.co/IKqBY06wai.
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