Ishmael Dehghan, PhD
@Ishmael_Deh
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Assistant Professor @UTSWMC | Specializing in proteomics, metabolomics, immunity, and aging | Let's uncover the secrets of longevity together.
Dallas, TX
Joined February 2023
“My parents could barely read or write. It’s been quite a journey, science allows you to do it.” New laureate Omar Yaghi was in the middle of changing flights when we reached him, just after he heard that he had been awarded the 2025 #NobelPrize in Chemistry. In this interview
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Congratulations to Zhijian “James” Chen, Ph.D., and Michael Rosen, Ph.D., on being named 2025 Citation Laureates by Clarivate for field-leading research on innate immunity and biomolecular condensates. Read more about their innovative work here: https://t.co/U5FdxKyIpR
#utswmed
utsouthwestern.edu
Two UT Southwestern Medical Center scientists – Zhijian “James” Chen, Ph.D., Professor of Molecular Biology and Director of the Center for Inflammation Research, and Michael Rosen, Ph.D., Chair and...
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Congratulations to #UTSW biochemist Zhijian “James” Chen, Ph.D., recipient of the 2026 Elaine Redding Brinster Prize in Science or Medicine for his discovery of the cGAS enzyme and its role in immune response. Learn more about the award.
utsouthwestern.edu
Zhijian “James” Chen, Ph.D., Professor in the Department of Molecular Biology at UT Southwestern Medical Center and one of the world’s top researchers on innate immunity, has been awarded the 2026...
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Steven McKnight, Ph.D., Professor of Biochemistry at #UTSW, is the 2025 Albert Lasker Basic Medical Research Award (@LaskerFDN) recipient for pioneering work on low-sequence complexity proteins and their impact on cellular organization and disease.
utsouthwestern.edu
Steven McKnight, Ph.D., Professor of Biochemistry at UT Southwestern Medical Center, has been awarded the Albert Lasker Basic Medical Research Award.
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Thrilled our work is the cover article in JCI Insight! We show that a population of hair follicle stem cells contributes to the epidermis during homeostasis, challenging the idea that skin and hair rely on separate stem cell pools. @JCI_insight @UTSWDerm @LuLe_MD_PhD
It has long been believed that skin and hair follicles are maintained by compartmentalized stem cells. This issue’s cover features work by @ElnazGhotbi, Lu Q. Le & team @UVA, @MedicineUVA on the contribution of hair follicle epithelial stem cells to interfollicular epidermis
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It has long been believed that skin and hair follicles are maintained by compartmentalized stem cells. This issue’s cover features work by @ElnazGhotbi, Lu Q. Le & team @UVA, @MedicineUVA on the contribution of hair follicle epithelial stem cells to interfollicular epidermis
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We’re deeply saddened by the passing of David “Davo” Mangelsdorf, Ph.D., Professor and Chair of Pharmacology at UTSW, whose work on orphan nuclear receptors transformed our understanding of metabolism and endocrinology and inspired countless scientists. https://t.co/9FWX2T4aEu
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High dietary phosphate intake promotes hypertension through a brain- mediated mechanism.
utsouthwestern.edu
Diets rich in phosphate additives, commonly found in processed foods, can increase blood pressure by triggering a brain signaling pathway and overactivating the sympathetic nervous system that...
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Congratulations to Zhijian "James" Chen, Ph.D., Professor of Molecular Biology @UTSWMedCenter, on being elected to the U.K.'s @royalsociety, the world's oldest scientific academy.
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Chronic stress hinders the cellular housekeeping process autophagy. Boosting it has the potential to restore normal neuronal activity and treat depression https://t.co/JsX1lWqgWH
nature.com
Nature - Boosting the recycling process known as autophagy — impaired in the brain during prolonged stress — has the potential to restore normal neuronal activity and treat depression.
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Great to see friends & colleagues at the Molecular Biology 30th Anniversary Symposium! Fantastic lineup of speakers. Huge thanks to the chair for making it such a great workplace, and to my former mentor @RueylingLin2 and current mentor James Chen for their invaluable support!
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Immune cells have unexpected role in fighting pain | Science | AAAS
science.org
Inflammation-suppressing regulatory T cells reduce pain in female mice by targeting nerve cells
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Vaccination against shingles might also prevent dementia, such as that caused by Alzheimer’s disease, according to a study of health records from around 300,000 people in Wales. https://t.co/KHUA5tAuW3
nature.com
Nature - Analysis of nearly 300,000 people finds an association between the shingles jab and a lower rate of dementia — but questions linger.
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Eating more fruits, veggies, whole grains, nuts, and low-fat dairy supports healthy aging, while trans fats, sodium, sugary drinks, and processed meats may contribute to health decline.
nature.com
Nature Medicine - In two longitudinal cohorts followed for 30 years, the associations of eight different dietary patterns with healthy aging—encompassing cognitive, physical and mental...
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Menopause seems to accelerate aging. New study shows mousopause 🐁 promotes cellular senescence—when old or damaged cells stop dividing & release harmful factors that speed up aging Does hormone replacement reduce senescence? https://t.co/Sv0AOpJfT7
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Omega-3 supplements slow biological ageing
nature.com
Nature - The anti-ageing effect was even greater when combined with vitamin D and exercise.
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Splitting hairs on hair regeneration! https://t.co/secA3D5xRH This month’s cover features research by @ElnazGhotbi @LuLe_MD_PhD & team on epidermal stem cells controlling hair formation. The cover image shows spheres within the strands of healthy hair representing stem cell
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I’m thrilled to share that my research is featured as the cover article in the Journal of Clinical Investigation! This work highlights the discovery of a novel population of epidermal stem cells that are ancestors to the formation of hair follicles. @LuLe_MD_PhD
Splitting hairs on hair regeneration! https://t.co/secA3D5xRH This month’s cover features research by @ElnazGhotbi @LuLe_MD_PhD & team on epidermal stem cells controlling hair formation. The cover image shows spheres within the strands of healthy hair representing stem cell
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Humanity is headed off a cliff as infertility becomes the 3rd most common disease of the 21st century, according to @WHO. Why infertility is increasing at such a pace is unclear A new study may shed light. Microplastics are shown to cause abnormalities in the mobility &
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This quote from Reinhold Niebuhr seems more resonant today after our democratic election 🧵
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