Elnaz Ghotbi, PhD
@ElnazGhotbi
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A scientist with expertise in epigenetics and epidermal stem cells. @UTSW_Surgery
Dallas, TX
Joined June 2023
Thrilled our work is the cover article in JCI Insight! We show that a population of hair follicle stem cells contributes to the epidermis during homeostasis, challenging the idea that skin and hair rely on separate stem cell pools. @JCI_insight @UTSWDerm @LuLe_MD_PhD
It has long been believed that skin and hair follicles are maintained by compartmentalized stem cells. This issue’s cover features work by @ElnazGhotbi, Lu Q. Le & team @UVA, @MedicineUVA on the contribution of hair follicle epithelial stem cells to interfollicular epidermis
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Honored to receive two distinct 2025 awards from the Trauma Research and Combat Casualty Care Collaborative (TRC4)-a Research Grant and a Fellowship supporting my work on the wound epithelium’s role in bone regeneration after digit amputation. Time to celebrate! 🎊🎉
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پوست ما مثل یه سد محکم از بدن محافظت میکنه و لایه بیرونی اون (اپیدرم) همیشه خودش رو نوسازی میکنه. دانشمندا (@ElnazGhotbi یعنی ایشون👏) فهمیدن که توی ریشه مو، سلولهای خاصی وجود دارن که با یه ژن (KROX20) مشخص میشن. این سلولها میتونن از ریشه مو حرکت کنن و به سطح پوست برسن و به
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It has long been believed that skin and hair follicles are maintained by compartmentalized stem cells. This issue’s cover features work by @ElnazGhotbi, Lu Q. Le & team @UVA, @MedicineUVA on the contribution of hair follicle epithelial stem cells to interfollicular epidermis
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Breathing polluted air increases the risk of #osteoporosis, growing evidence shows. Learn more: https://t.co/yefR698Y3l
#ScienceMagArchives
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Menopause seems to accelerate aging. New study shows mousopause 🐁 promotes cellular senescence—when old or damaged cells stop dividing & release harmful factors that speed up aging Does hormone replacement reduce senescence? https://t.co/Sv0AOpJfT7
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Splitting hairs on hair regeneration! https://t.co/secA3D5xRH This month’s cover features research by @ElnazGhotbi @LuLe_MD_PhD & team on epidermal stem cells controlling hair formation. The cover image shows spheres within the strands of healthy hair representing stem cell
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I’m thrilled to share that my research is featured as the cover article in the Journal of Clinical Investigation! This work highlights the discovery of a novel population of epidermal stem cells that are ancestors to the formation of hair follicles. @LuLe_MD_PhD
Splitting hairs on hair regeneration! https://t.co/secA3D5xRH This month’s cover features research by @ElnazGhotbi @LuLe_MD_PhD & team on epidermal stem cells controlling hair formation. The cover image shows spheres within the strands of healthy hair representing stem cell
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BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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“My message to the young people is this: if I can get so close to the stars, you can too.” —Zhijian “James” Chen, 2024 #LaskerAward winner for his discovery of cGAS, an enzyme that senses self and foreign DNA #Lasker2024 #LaskerLaureate @UTSWMedCenter
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Kamala's mother immigrated from India to pursue a PhD & stayed to work as a cancer researcher Kamala's father immigrated from Jamaica to pursue a PhD & stayed to work as a professor Immigrant scientists contribute not only to science but to society at large -- for generations
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“Papers need to include fewer claims and more proof to make the scientific literature more reliable”. William G. Kaelin Jr.
Publish houses of brick, not mansions of straw | Nature
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I'm ecstatic to share my postdoc work @UTSWMedCenter @LuLe_MD_PhD lab published today as the cover article of @jclinicalinvest. We show that #STING activation in the aggressive "cold" tumor #MPNST turns it "hot" making it targettable by immune checkpoint blocking.
#Cover: STING activation sensitizes malignant peripheral nerve sheath tumors to immunotherapy: https://t.co/NwqK99ZXhE Image: MPNST (blue) targeted for immune destruction by infiltrating T cells (pink); Credit: Bandarigoda Somatilaka. @LuLe_MD_PhD @UTSWMedCenter
#Oncology
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Christmas lab lunch! So grateful to be part of this amazing research team!
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Frustrated in the uphill battle of publishing novel data! Facing resistance to new, well-supported findings that challenge the status quo is daunting. Novel findings should not necessarily fit into old boxes, yet they often face the hardest pushback!
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Our DARLIN paper is out. We hope that this model really enables and facilitates single cell lineage tracing experiments in the mouse. Thanks specially to @Li_Li_666 and @ShouwenW. More exciting uses of the technology coming out soon... https://t.co/iGslF85QuC
cell.com
DARLIN is an inducible barcoding system that allows for lineage tracing and analysis across mouse tissues as well as combined transcriptional and epigenomic single-cell measurements.
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Nature research paper: Epigenetic regulation during cancer transitions across 11 tumour types
nature.com
Nature - A pan-cancer epigenetic and transcriptomic atlas identifies epigenetic drivers associated with cancer transitions.
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An inspiring interview with Katalin Karikó, the new medicine laureate! She talks about her scientific journey and her determination to focus her energy on creating impactful changes. Heartwarming stories about her supportive mom and Olympic gold medalist daughter also feature.
“Ten years ago I was kicked out and forced to retire.” Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her
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