Esak (Isaac) Lee
@IsaacLeeLab
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Meinig Family Investigator and Assistant Professor @ Cornell Biomedical Engineering, Organ-on-Chip, Lymphatics, Cancer, Neurological Disease (eye and brain)
Ithaca, NY
Joined August 2019
Thrilled to be selected for the @theNAEng Grainger Foundation Frontiers of Engineering 2025 U.S. Symposium! Honored to join 73 incredible early-career engineers shaping the future. Congratulations to all! đź‘Ź.
Congratulations to the seventy-four highly accomplished, early-career engineers selected to participate in The Grainger Foundation Frontiers of Engineering 2025 U.S. Symposium! Find the complete list of selected participants here: @FrontiersNAE
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Thanks for sharing~ @aplbioeng !!.
Lee et al used a brain-on-a-chip model to show that in Alzheimer’s, toxic tau protein makes brain support cells (astrocytes) overly contract, squeezing vessels and blocking brain waste clearance. Learn more 👇 .
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RT @Zihai: NIH announces end to funding for animal-only studies
drugdiscoverytrends.com
Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.
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Thanks for sharing @PancreaticCell.
Dr. Esak Lee (@IsaacLeeLab) and his team at @Cornell have identified ALK7 inhibition as a promising strategy to target early metastatic dissemination in #PDAC. Read the paper in Molecular Cancer:
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Thanks for sharing! @ExtracellMatrix.
Researchers in the @IsaacLeeLab identified two distinct but interconnected ALK7-driven non-canonical pathways that promote #PDAC dissemination. Check out their paper:
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New paper out in Molecular Cancer (Impact Factor: 33.9). We combined tumor-on-chip + in vivo models to uncover early steps of pancreatic cancer metastasis. Led by Drs. Kolarzyk & Kwon, in collaboration with Drs. Won Kyu Kim (KIST) and Manuel Hidalgo (WCM)!
molecular-cancer.biomedcentral.com
Breaching the vascular barrier is a critical step in pancreatic ductal adenocarcinoma (PDAC) metastasis, yet the mechanisms enabling this process remain incompletely understood. Transforming growth...
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🚨 Excited to share our new tauopathy-on-chip study! We show that astrocyte-driven vasoconstriction impairs glymphatic clearance in human Alzheimer's disease. Led by Rena Park, @HarryPengys, @CornellBME, @IsaacLeeLab #TauopathyOnChip #Alzheimers.
pubs.aip.org
The glymphatic system is a critical pathway for clearing metabolic waste from the brain by mediating cerebrospinal fluid and interstitial fluid exchange. In Alz
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RT @gou_koh: I would like to share our team's invaluable study on the non-invasive mechanical control of CSF outflow via the meningeal and….
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RT @IwijnDeVlaminck: Check out this new work in @NatureMaterials by my brilliant @CornellBME colleague Shaoyi Jiang: zwitterionic lipid nan….
nature.com
Nature Materials - Poly(carboxybetaine) lipids enhance mRNA lipid nanoparticles efficacy and reduce their immunogenicity, being promising alternatives to poly(ethylene) glycol lipids used in...
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RT @JHUBME: The application for the 2025 Rising Stars in Engineering in Health Workshop is now open! The two-day interactive workshop will….
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RT @CornellBME: Future biomedical engineering faculty, apply to join us at @Columbia for 6th Annual Rising Stars in Engineering in Health w….
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RT @NIH: Today, NIH announced a new initiative to expand innovative, human-based science while reducing the use of animals in research. Thi….
nih.gov
New initiative aims to reduce use of animals in NIH-funded research.
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RT @US_FDA: Today, the FDA is taking a groundbreaking step to advance public health by replacing animal testing in the development of monoc….
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RT @Jun_kiim: Published in Nature (2023), Kruse et al. (Tüting lab) demonstrate that adoptively transferred CD4+ T cells alone—but not CD8+….
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RT @endothelialnews: Researchers from Dr. Taija Mäkinen's lab (@makinenlab), including Dr. Hans Schoofs and Nina Daubel investigated the sp….
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RT @CornellBME: Yansong (Harry) Peng, a @CornellEng @IsaacLeeLab biomedical engineering Ph.D. candidate, selected for an International Foun….
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RT @NatureCVR: ❤️Our February issue is out❤️ Discover how neonatal heart regeneration extends to the conduction system, a new kinase contro….
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