Extracellular Matrix News
@ExtracellMatrix
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An online resource for the extracellular matrix and tissue engineering research community. Part of the @STEMCELLTech Science News service.
Joined June 2010
๐ฅผ Science News by @STEMCELLTech can help you stay on top of the latest cell biology research! ๐ Our website and newsletters keep scientists current with the latest peer-reviewed research, as well as industry and policy news. Learn more ๐ //bit.ly/3Xn6mwV
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๐ฌ Researchers engineered platelet membrane-fused vesicles that synergistically combine collagen targeting for ischemic injury homing with immune evasion. @NatureComms | https://t.co/9nxRIZ3C5t
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๐ฌ This study investigates the therapeutic mechanism in fibrotic foci reconfiguring via the TNF signaling pathway by potential Swertia chirayita components to treat pulmonary fibrosis by network pharmacology, in silico, and in vitro studies. @SciReports | https://t.co/dlLXueRE6z
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New research from @McGowanRM suggests that extracellular matrix (ECM) biomaterials may suppress esophageal cancer cell growth and migration. Biochemical cues from non-malignant ECM could help modulate cancer behavior after resection. Read more here: https://t.co/BXtuqMlBa2
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Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrix
cell.com
Iwata et al. show that the small GTPase RHOA regulates cell invasion in 3D environments, with effects shaped by ECM composition and cellular context. They demonstrate that RHOA knockout slows...
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New Research: Extracellular vesicle miR-425-5p promotes visceral fat reduction via DACT1 suppression in SGLT2i-treated diabetes https://t.co/HEbbdF9O9P
#FrontiersIn #Endocrinology
frontiersin.org
ObjectiveIn type 2 diabetes (T2D), plasma-derived extracellular vesicle (EV)-microRNAs (miRNAs) contribute to insulin resistance and ฮฒ-cell dysfunction. Sodi...
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๐ง This study suggests that targeting the CCL2/CCR2/ERK1/2 pathway may help overcome chemoresistance in #glioblastomas caused by cancer-associated fibroblasts! @oncogenejournal | https://t.co/xH84h5UMUD
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๐ฅผ Scientists support a potential causal and organ-specific role of pancreatic #fibrosis in the pathogenesis of type 2 diabetes, highlighting pancreatic fibrosis as a mechanistically plausible and potentially targetable target in diabetes prevention. ๐ https://t.co/faOq83pwG8
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๐ฏ Researchers design a sharply pH-activated single-chain collagen mimetic peptide probe, TEMPO, for highly specific tumor ECM-targeting. @an_chem | https://t.co/hU6x7B8ppx
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๐ฅ๏ธ This study underscores an ECM-guided design for real-time monitoring and timely interventions in pressure ulcers. Check it out! ๐ @acsnano | https://t.co/BAMmLi5oxO
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๐งช Researchers designed and fabricated a multifunctional, sandwich-structured wound dressing using 3D bioprinting technology. This multilayer scaffold represents a promising novel wound dressing for skin regeneration applications. ๐ https://t.co/EuMyrAsy5F
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๐งซ Scientists present the formation of vascular networks of human umbilical vein endothelial cells co-cultured with stromal cells (SCs), human dental pulp SCs, or human adipose SCs, in natural hydrogels as well as xeno-free VitroGel hydrogels. @SciReports |
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๐ Scientists examined the application of magnesium-based metallic materials for #osteosarcoma treatment, specifically assessing the impact of a magnesium-calcium alloy/mineralized collagen composite on osteosarcoma cell biological behavior. @SciReports | https://t.co/h92R4Cv1Uh
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๐งฌ Researchers show that adipocyte-derived soluble factors alter the transcriptional landscape of muscle cells, especially genes involved in ECM remodeling and metabolic regulation. ๐ https://t.co/r3W5wUjxlL
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๐ This study investigated the therapeutic potential of platelet-derived growth factor-BB, delivered via sodium hyaluronate, in modulating osteoarthritis chondrocyte microstructure and cytoskeletal dynamics. ๐ https://t.co/zl1n4N26Ud
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๐ซ As a model of lung fibrosis, primary HLF derived from non-IPF and IPF donors were stimulated with TGF-ฮฒ; collagen 1A1 and PAI expression were then measured in the presence and absence of cAMP mobilizing agents. ๐ https://t.co/wewVfBQFHc
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๐ฆด Researchers investigated a 3D microporous demineralized bone matrix combined with bone marrow mesenchymal stem cells to enhance the outcomes of bone defect repair. ๐ https://t.co/ZgddFek6ra
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๐งช Check out this bioorthogonal crosslinking strategy using rhodamine and polyethylene glycol, reported to fabricate dense, mechanically reinforced collagen hydrogels. ๐ https://t.co/lCRVcgUr9e
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๐งซ In this study out of @UTAustin, clinical use of current dECM biomaterials, advances in the fabrication of dECM biomaterials, and hurdles to clinical translation of dECM products are discussed. ๐ https://t.co/yl7Z2qXjSe
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๐งช Inspired by the ECM structure of the pancreatic islets, an injectable self-healing hydrogel loaded with #islet-integrated microfiber scaffolds was constructed for islet transplantation. ๐ https://t.co/IXpxV9unqV
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๐ Researchers investigated the role of paraspeckles and the long non-coding RNA Neat1 in transforming growth factor-ฮฒ1-induced stem cell fate determination. ๐ https://t.co/uqMxk6iplg
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