Excited to share our new findings in collaboration with the @Gritsman_lab! We identified a novel #AML vulnerability—TTLL4 glutamylates NPM1c to support leukemic growth. Knocking it down drives differentiation and improves survival. Preprint:

Failure is always in the background of any creative project; when the experiments are not working or the results don’t seem to make sense. But for discovery, you can’t deny yourself the permission to fail, and we should better teach failure in all its glory.

When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018. Read more on #STEMSTEAMDay: https://t.co/xtOAX8sof0

Marcus Rhoades: “I’ve often marveled that you can look at a cell under the microscope and can see so much!” Barbara McClintock: “Well, you know, when I look at a cell, I get down in that cell and look around.”

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

An amazing experience at the #cshlepich24 meeting. I had the awesome opportunity to present my research elucidating the mechanism of mutant NPM1 mediated AML & engage in enlightening discussions with incredible people in the field. @cshlmeetings

A professionally taken photo can aid early career scientists in their profession. That’s why the Belfer Institute of Advanced Biomedical Studies and Einstein hosted a day-long photo session for #postdocs as part of its #NationalPostdocAppreciationWeek celebration. #NPAW2023

Charging Up Histone Chaperones: Glutamylation's DNA Mimicry Powers Revealed. Find our preprint here https://t.co/SG8YK3X1Ij Thank you @DShechter @B_Lorton23 and others in the team. #DNA #Chaperone #preprint #research #NMR #bioRxiv

Ever wonder why histone chaperones have acidic tails? Our new preprint reveals they mimic DNA to regulate chromatin! Glutamate-glutamylation enhances their mimicry. Dive in: https://t.co/n1MIumdmGe lead by @B_Lorton23 Chris Warren @HumairaIlyas8 #biorxiv 1/7

From Disorder to Dynamo: Glutamylation's Role in Supercharging Histone Chaperones I am thrilled to share our latest and groundbreaking work on histone chaperone glutamylation. Find our preprint here https://t.co/gvpjs1lgHi Thank you @DShechter and others for your contributions!

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency https://t.co/zCiHP44pjE #bioRxiv

Cells are very fast and crowded places. A molecule of glucose flies through a cell at 250 mph. A protein tumbles 60 million times per minute. These numbers seem made up. How did we figure this stuff out?

Yesterday, at @Regeneron Science to Medicine forum. Great talks, & exciting scientific discussions from academics in @EinsteinMed @Columbia @MountSinaiNYC among others. Good exposure into biotech industry- working & opportunities by @davidjglassMD & team.

Teach principles, not formulas. Understand, don't memorize.

15 years ago my PhD advisor taught me One Weird Trick for editing your own writing. Edit **back to front**, paragraph by paragraph. I still use it and it still surprises me how well it works. When I get my students to do it, it often blows their minds. Try it!

Einstein postdocs are the best!! @EinsteinMed @nationalpostdoc @epa_einstein @EinsteinPhD #NPAW2022

If you want to master something, teach it.

We had a great time with our postdocs!! @EinsteinMed @nationalpostdoc @epa_einstein @EinsteinPhD

It doesn’t matter what you eat; if you eat too much (volume) of food, you’ll be tired. It’s called blood flow diversion. Eat to 85% full and you’ll avoid this source of fatigue. #science

You're under no obligation to remain the same person you were a year ago, a month ago, or even a day ago. You are here to create yourself, continuously.