Popel Systems Biology Lab
@HopkinsPopelLab
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Popel Systems Biology Lab at @JohnsHopkins @JHUBME @HopkinsMedicine @HopkinsEngineer. Computational Systems Biology, QSP, Angiogenesis, Cancer Immunotherapy
Baltimore, Maryland
Joined April 2020
Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade | PNAS
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RT @The_MCSociety: We all enjoyed and were inspired by Shayn Peirce-Cottler’s talk! Congratulations on being the 2024 Eugene M. Landis Awar….
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RT @IsaacLeeLab: Just had an amazing dinner with my PhD advisor, Dr. Sasha Popel @HopkinsPopelLab @JHUBME. His exceptional mentoring has be….
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RT @DoloffLab: Many congrats to @JGreenGroup on your installation as the Herschel L. Seder endowed Professor of @JHUBME! .
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RT @zhangshuming199: Really thankful to my mentors. Wouldn’t be possible without my awesome advisors @FertigLab @ltkagohara @HopkinsPopelLab.
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Our latest modeling work integrates signaling and biophysical modeling to investigate how red blood cells are recognized and recycled in sickle cell disease, now in @PNASNexus. Thank you to our colleagues and collaborators at @jhubme @BrownUniversity @MIT
academic.oup.com
Abstract. Red blood cell (RBC) aging manifests through progressive changes in cell morphology, rigidity, and expression of membrane proteins. To maintain t
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RT @PNASNexus: Watch a simulation of a macrophage engulfing an old, rigid red blood cell that needs to be recycled. The simulation was prod….
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Congratulations!!!.
after sharing the news with family and friends, i am thrilled to announce that i have been promoted to Professor of Biomedical Engineering and Quantitative and Computational Biology @USC !! .@USCViterbi @uscbme @qcb_usc
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RT @ltkagohara: A few months ago, I posted about the @biorxivpreprint for spatial transcriptomics analysis of HCC. The paper is now publis….
genomemedicine.biomedcentral.com
Background Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about...
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RT @zhangshuming199: Huge thanks to team members in @HopkinsPopelLab and @FertigLab. Shout out to @ltkagohara and @atulpdeshpande for great….
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RT @jclinicalinvest: Macrophage–endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa: .
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RT @UVACOWIMS: This month, COWIMS highlights Dr. Shayn Peirce-Cottler for her brilliant work as Professor and Chair of Biomedical Engineeri….
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RT @IbraChamseddine: A much needed call from @MathCancer to create a “Modeling Grammar.” A dictionary for hypothesis rules, modeling compon….
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Please see our latest work, just published on @ScienceAdvances: A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition.
science.org
In-silico clinical trial facilitates selection of patients for immunotherapy targeting PD-1 in metastatic breast cancer.
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Congratulations to Theinmozhi Arulraj! Her amazing work on omics-informed #QSP model of #breastcancer metastasis has won the Oncology Session Award at the @ISOP1 QSP Student Symposium 2023!
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Our review of systems biology models and omics of angiogenesis signaling published in @WIREs_Reviews is among the top downloaded papers! .Read on for more:
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We are thrilled to share our latest paper "Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico …." published in @Cancers_MDPI. 📷. Read the paper: [ 📷. Congrats to the team and @mehdinik85 📷.#QSP #ABM #ITH #CancerStudies.
mdpi.com
Spatial heterogeneity is a hallmark of cancer. Tumor heterogeneity can vary with time and location. The tumor microenvironment (TME) encompasses various cell types and their interactions that impart...
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RT @mehdinik85: As a postdoc at @HopkinsPopelLab,@JHUBME., I'm thrilled to share our latest paper "Quantifying Intratumoral Heterogeneity a….
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