Herzon Lab
@HerzonLab
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Student run twitter for the Herzon Lab @Yale
New Haven, CT
Joined September 2018
RT @MartinTomanik: Out today in @J_A_C_S is the first synthesis from our group!! We report a convergent and stereoselective total synthesis….
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RT @YulabJin: Absolutely beautiful !@MartinTomanik your team beats everyone in using these two bifunctional pyridone ligands for CH hydroxy….
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RT @TotalSynthesis: #TotalSynthesis of Chartelline C by Noah M. Bartfield (@NaOHBartfield), Brandon W. Alexander, and Seth B. Herzon @Herzo….
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RT @J_A_C_S: Total Synthesis of Chartelline C | Journal of the American Chemical Society @Yale @YaleChem
pubs.acs.org
Chartellines are cytotoxic marine alkaloids that were isolated in the late 1980s. Their unique, heavily oxidized structures, comprising a spirocyclic β-lactam, a halogenated indolenine, a chloroena...
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The total synthesis of chartelline C! . Accomplished in a small number of transformations from material intercepted en route to the securamines. Each step was informed by the unique topology and unconventional reactivity of these isolates 🥳🙌.
pubs.acs.org
Chartellines are cytotoxic marine alkaloids that were isolated in the late 1980s. Their unique, heavily oxidized structures, comprising a spirocyclic β-lactam, a halogenated indolenine, a chloroena...
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Congratulations to our undergraduate trainee, Sam Charney, for receiving a 2025 Summer Undergraduate Research Fellowship from the ACS DOC!.
The Division of Organic Chemistry (DOC) congratulates the sixteen 2025 DOC Summer Undergraduate Research Fellowship (SURF) awardees and gratefully acknowledges the generous sponsors.
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Prof. Seth Herzon accepting the @AmerChemSociety Award for Creative Work in Synthetic Organic Chemistry at the 2025 American Chemical Society meeting in San Diego. The group is proud to accept this honor!. Photo credits:
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RT @Phil_Knutson: Some of these natural products were made by @BaranLabReads @HoveydaLab @Shenvi_Lab @KrischeLab @GargLab @HerzonLab @Johns….
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RT @YaleCancer: Congratulations to the 7 members of @YaleCancer receiving Blavatnik Awards: Dr. Demetrios Braddock @yalepathology; @CraigMC….
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A Stereoselective Oxidative Dimerization En Route to (−)-Lomaiviticin A. This strategy enables access to the natural stereoisomer of the lomaiviticin skeleton, featuring a highly diastereoselective late-stage dimerization. Out now in @JOC_OL! (1/2).
pubs.acs.org
We describe a stereoselective synthesis of the dimeric diazofluorene 15, a potential precursor to the cytotoxic C2-symmetric bacterial metabolite (−)-lomaiviticin A (1). An efficient route was...
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RT @YaleCancer: Seth Herzon, PhD, @YaleChem @HerzonLab and Smita Krishnaswamy, PhD, @YaleGenetics @YaleCSDept selected as recipients of the….
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RT @ranjitbindra: ICYMI: excited to end the year with a wonderful biotech exit 🙌🏽🙏🏽… one step closer to a new class of therapeutics for GBM….
pharmavoice.com
Merck’s acquisition of Modifi Biosciences bucks common M&A trends in pharma.
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RT @YaleChem: Congrats to Brandon Mercado @Fullerene , our X-ray crystallographer! He received the Lorimer Award for helping to bring Micro….
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RT @Merck: Today, we announced an agreement to acquire Modifi Bio and the company’s preclinical compounds designed to exploit DNA repair de….
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We are thrilled to announce today an agreement with @Merck which will acquire the Modifi compounds and advance them to the clinic! We are so happy to enter into this partnership with Merck and are optimistic that this science will rapidly benefit patients.
globenewswire.com
Merck gains preclinical compounds designed to exploit DNA repair defects in difficult to treat cancers...
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The Modifi molecules are based on fundamental chemical synthetic and molecular biological studies carried out jointly between the Herzon and Bindra (@ranjitbindra) laboratories at Yale and published in Science ( and JACS (. (2/3)
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In 2021, we founded Modifi Biosciences ( to develop new treatments for cancers such as glioblastoma, a fatal and incurable form of brain cancer. (1/3).
merck.com
At Merck, we're following the science to tackle some of the world's greatest health threats. Get a glimpse of how we work to improve lives.
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RT @Yale_Ventures: Congratulations to #Yale spinout @modifibio on their acquisition by @Merck. Merck gains preclinical compounds designed….
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RT @MCWhiteGroup: Tour de force Fuson lectures from Seth Herzon @HerzonLab spanning from a riveting total synthesis story of the Securiflus….
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