Krische Lab
@KrischeLab
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Synthetic Methods and Natural Product Synthesis @ UT Austin
Austin, TX
Joined January 2019
Many thanks to former group members for their hospitality in Tokyo!
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Many thanks to colleagues at Tohoku University for a wonderful visit!
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Return of T-Schempp (aka Tabitha), destroyer of Soraphen and star alumnus at Eli Lilly, San Diego!
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Congratulations to Prof. Yu-Rong Yang on the total synthesis of rubriflordilactone A via late-stage Ir-catalyzed 2-(alkoxycarbonyl)allylation!
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Congrats to Yu-Hsiang, Yoon and Weijia formate-ing dreams come true!
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This abundant, safe and environmentally benign hydrogen transfer agent enables this method to bypass the conversion of organic halides to premetalated cross-coupling partners using hazardous organometallic reagents (3/3). @NatureChemistry @genentech @PittTweet @UMNews.
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In breakthrough work with researchers at Genentech, University of Pittsburgh and University of Minnesota, the Krische laboratory has merged these two processes, enabling direct cross-coupling of organic halides via hydrogen transfer using sodium formate (2/3).
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Catalytic hydrogenation and metal-catalyzed cross-coupling are among the most broadly utilized methods in small-molecule drug discovery and manufacture (1/3).
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A big thanks to Dylan Snelson and the students of SCRIPPS for a day filled with exciting science, including the honor of meeting one of my chemistry heroes, Prof. Barry Sharpless!
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Congrats to Prof. Krische, who has been awarded the 2025 Yamada-Koga Prize for his breakthrough work on enantioselective C-C coupling via hydrogenation and transfer hydrogenation!.
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Congratulations to “team ruthenium” on unlocking a broad, new (and directing-group-free) method for heteroaryl C-H functionalization using our concept of hydrogen auto-transfer! @J_A_C_S .
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Best Christmas gift ever from best students ever! They know me too well! Remember, vitamin D(og) is essential for good health!
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Congratulations to Jessica and Kate on their Chemical Reviews article summarizing the many applications of our catalytic methods in natural product total synthesis. @ACSChemRev.
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Congratulations to Guanyu (Brad) Hu, Rosalie Doerksen and Brett Ambler on completing the first total synthesis of type II polyketide antibiotic formicamycin H! @J_A_C_S .
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Congratulations to Cate, Sarah, Maddie and Jon on this fundamental contribution to catalytic cross-coupling beyond premetalated reagents or metallic reductants! @JOC_OL .
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Many thanks to Nick White & Melissa Ashley of Genentech for hosting my graduate students Weijia Shen & Yu-Hsiang Chang for summer 2024 internships - a rewarding experience that has led to some exceptional research findings! @genentech
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RT @UTChemistry: We're honored to host Joseph Moran of @uOttawa & the University of Strasbourg, one of this year's Distinguished Alumni Le….
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RT @MoranLabChem: Great to be back in Austin and @UTChemistry for the first time since my postdoc. Thanks @KrischeLab @WizardsOfOztin @hull….
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