Krische Lab
@KrischeLab
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Synthetic Methods and Natural Product Synthesis @ UT Austin
Austin, TX
Joined January 2019
The Austin-Gifu chemistry connection continues with a visit from Prof. Eiji Yamaguchi!
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Congrats to Cate, Peyton and Zach – diols are twice the alcohol and twice the fun!
pubs.acs.org
Reported methods for enantioselective oxidative lactonization affect desymmetrization of prochiral or meso-diols, and processes where C–C bond formation accompanies oxidative lactonization are...
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It's official! The third biennial WCSC is Nov. 15th, co-hosted by the @hull_group. Undergrads, grad students, post-docs, and faculty are welcome to register here: Thank you to our sponsors @Amgen @genentech @pfizer @AmerChemSociety. Hope to see you there!
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Many thanks to former group members for their hospitality in Tokyo!
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Many thanks to colleagues at Tohoku University for a wonderful visit!
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Return of T-Schempp (aka Tabitha), destroyer of Soraphen and star alumnus at Eli Lilly, San Diego!
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Congratulations to Prof. Yu-Rong Yang on the total synthesis of rubriflordilactone A via late-stage Ir-catalyzed 2-(alkoxycarbonyl)allylation!
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Congrats to Yu-Hsiang, Yoon and Weijia formate-ing dreams come true!
pubs.acs.org
Catalytic methods for the intermolecular formate-mediated C–C coupling of Csp2-X pronucleophiles beyond reductive Heck reactions (alkene hydroarylations) are catalogued. These methods include...
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Congrats to Dana on the formal synthesis of fostriecin!
pubs.acs.org
A formal synthesis of fostriecin via convergent assembly of two fragments prepared via asymmetric alcohol-mediated C–C coupling is described. One fragment is made by the enantioselective iridium-ca...
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This abundant, safe and environmentally benign hydrogen transfer agent enables this method to bypass the conversion of organic halides to premetalated cross-coupling partners using hazardous organometallic reagents (3/3). @NatureChemistry @genentech @PittTweet @UMNews.
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In breakthrough work with researchers at Genentech, University of Pittsburgh and University of Minnesota, the Krische laboratory has merged these two processes, enabling direct cross-coupling of organic halides via hydrogen transfer using sodium formate (2/3).
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Catalytic hydrogenation and metal-catalyzed cross-coupling are among the most broadly utilized methods in small-molecule drug discovery and manufacture (1/3).
nature.com
Nature Chemistry - Transfer hydrogenation is challenging to apply to aryl halide reductive cross-couplings because of competing hydrogenolysis. Now aryl halide cross-couplings mediated by sodium...
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A big thanks to Dylan Snelson and the students of SCRIPPS for a day filled with exciting science, including the honor of meeting one of my chemistry heroes, Prof. Barry Sharpless!
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Congrats to Prof. Krische, who has been awarded the 2025 Yamada-Koga Prize for his breakthrough work on enantioselective C-C coupling via hydrogenation and transfer hydrogenation!.
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Congratulations to “team ruthenium” on unlocking a broad, new (and directing-group-free) method for heteroaryl C-H functionalization using our concept of hydrogen auto-transfer! @J_A_C_S .
pubs.acs.org
A novel mechanism for N-heteroaryl C–H functionalization via dearomative addition-hydrogen autotransfer is described. Upon exposure to the catalyst derived from RuHCl(CO)(PPh3)3 and Xantphos, dienes...
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Best Christmas gift ever from best students ever! They know me too well! Remember, vitamin D(og) is essential for good health!
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Congratulations to Jessica and Kate on their Chemical Reviews article summarizing the many applications of our catalytic methods in natural product total synthesis. @ACSChemRev.
pubs.acs.org
Catalytic enantioselective hydrogen autotransfer reactions for the direct conversion of lower alcohols to higher alcohols are catalogued and their application to the total synthesis of polyketide...
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Congratulations to Guanyu (Brad) Hu, Rosalie Doerksen and Brett Ambler on completing the first total synthesis of type II polyketide antibiotic formicamycin H! @J_A_C_S .
pubs.acs.org
The first total synthesis of the pentacyclic phenylnaphthacenoid type II polyketide antibiotic formicamycin H is described. A key feature of the synthesis involves the convergent, regioselective...
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Congratulations to Cate, Sarah, Maddie and Jon on this fundamental contribution to catalytic cross-coupling beyond premetalated reagents or metallic reductants! @JOC_OL .
pubs.acs.org
Formate-mediated reductive cross-couplings of vinyl halides with aryl iodides via palladium(I) catalysis occur with highly uncommon cine-substitution. The active dianionic palladium(I) catalyst,...
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