
Helena Shomar
@HelenaShomar
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Antivirals & antibiotics from bacteria/MCSA-ParisR Fellow @MDMlab_Paris/SynBio & Metabolic Engineering/Bioart & Biodesign enthusiast/SciComm & Education🇫🇷🇲🇽
Paris, France
Joined March 2013
In the spirit of the New Year and new beginning, here some news☀️: 1. Some updates about my next professional adventure (spoiler alert: I left academia) 2. I have decided to leave Twitter ! More on these points below 👇 If you wanna keep in touch:
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Two years ago we published the discovery of hotspots of novel anti-phage defense systems in the genome of P4 phage satellites, including a mysterious Phage Anti-Restriction Induced System (PARIS). We have now published the mechanism in @Nature
nature.com
Nature - Structural and functional studies reveal how viral proteins trigger the phage antirestriction induced system (PARIS) to degrade host tRNA and how viral tRNAs suppress the PARIS nuclease...
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AMAZING ! Well deserved!!!! David and Demis have been my personal Beyonce and Rihanna for years 🤩🤩🤩
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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My cat Shouka came to the lab for his monthly meeting to help us with BGC refactoring #NaturalProductsCat
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After a high dose of psilocybin, the brain desynchronizes at a massive scale, causing loss of our sense of self, time, and space. This may drive the burst of plasticity caused by psychedelics. The next day, brain activity has largely returned to normal, but an echo remains – a
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1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome #SyntheticBiology
https://t.co/efTztuluN9
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Scientists in France have expressed relief that the right-wing party National Rally was defeated in yesterday’s parliamentary elections
nature.com
Nature - With no party winning an outright majority, the vote’s implications for research are unclear.
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Together with @AudeBer we wrote a research briefing: "Evolutionary history of an immune protein conserved across all domains of life" https://t.co/LFcKK1uetz Link PDF: https://t.co/vW8MOy3Uj7 We describe our findings recently published in @NatureEcoEvo : https://t.co/7xGSXETP2S
nature.com
Nature Ecology & Evolution - Systematic analysis of viperin sequences, a family of immune genes that are highly conserved across diverse prokaryotes and eukaryotes, shows that eukaryotic...
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Yasmine Belkaid, directrice générale de l’Institut Pasteur : « Aujourd’hui, j’ai peur de perdre ce qui m’a fait choisir la France » https://t.co/6Nf5vbVKO7 via @lemondefr
lemonde.fr
TRIBUNE. L’imunologiste à la tête de l’Institut Pasteur s’alarme, dans une tribune au « Monde », du coup d’arrêt porté à la recherche et la science, si un gouvernement limitait la circulation...
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What a week!🥳 Our work describing the functional and evolutionary history of viperins is finally out! We describe how this ancient immune gene was conserved and diversified across the tree of life ! Hope you enjoy the final version of the manuscript 😀
Our paper on the evolutionary history of Viperins is now out in Nature Ecology and Evolution @NatureEcoEvo : https://t.co/Q2yBA7Pf02 🤩 As for other papers from the lab, we created an outreach video summarizing our findings here:
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Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold https://t.co/ENup6dRsUQ
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Paper out today: “RNA-guided RNA Silencing by an Asgard archaeal Argonaute”. A wonderful, multidisciplinary project co-led with @DCSwarts @ChirlminJoo_Lab, spearheaded by @C_Bastiaanssen @pilar_bobadilla @k1jun_ @FinocchioGiada & Yanlei Feng. https://t.co/Yh3wXAYFc3
@NatureComms
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A new kid on the block of "chemical defense" against phage infection. @HelenaShomar reports on the antiphage activity of lanthipeptides. Remembering early discussion in Portugal and now looking forward to reading your beautiful work! @SPP2330
🚨Super excited to share our pre-print describing how we used genomics to discover a family of anti-phage lanthipeptides from Actinobacteria 🦠 This marks a significant expansion in the number of bacterial natural products involved in chemical defense. A thread 👇: @MDMlab_Paris
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Modified peptides produced by bacteria protect from phage infection - congrats @HelenaShomar and @AudeBer for this fantastic discovery! Can these new antiviral molecules also inhibit viruses that infect humans? 🤔
🚨Super excited to share our pre-print describing how we used genomics to discover a family of anti-phage lanthipeptides from Actinobacteria 🦠 This marks a significant expansion in the number of bacterial natural products involved in chemical defense. A thread 👇: @MDMlab_Paris
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Bacteria produce chemical compounds that humans harness as drugs (ex antibiotic). We hypothesize that a major biological role of these compounds have been overlooked: antiviral defense. 👇Discovery of lantiphages, a large BGC family wt antiphage function https://t.co/G1jeujZXQh
biorxiv.org
Bacteria synthesize natural products to adapt to their environment, where phage-bacteria interactions play a crucial role in bacterial ecology. Although a few natural products have been shown to...
🚨Super excited to share our pre-print describing how we used genomics to discover a family of anti-phage lanthipeptides from Actinobacteria 🦠 This marks a significant expansion in the number of bacterial natural products involved in chemical defense. A thread 👇: @MDMlab_Paris
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3 years ago we started this very risky project with @AudeBer, when her lab was just starting ! I am still processing all the cool science we did together and with the help of many great collaborators. I hope you like this manuscript as much as we do ! 😃🍾
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Looking forward to discovering more anti-phage compounds! This work was an awesome collaborative effort with F Tesson, M Guillaume @MDMlab_Paris & @VeroniqueO5 @ClaessenLAB @BriegelAriane Daniel Rozen @GillesvanWezel @LeidenBiology & @SeverineZirah Yanyan Li @MNHN_recherche
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