Guoting Zhang
@GuotingZhang
Followers
107
Following
57
Media
0
Statuses
25
Assistant Professor@Fudan; Postdoc@EPFL；Postdoc@Stanford
Vaud, Switzerland
Joined September 2020
🚨 Our first Science paper 🚨 We report the isolation and reactivity of the first “inaccessible” 5-membered heteroaryne! 120+ year challenge! Congrats @jennahumke @belli_roman @ErinPlasek @Sal_K_3 @annabelly24 @CortnieRoberts @UMNChemistry @ScienceMagazine
science.org
N-Heteroaromatics are key elements of pharmaceuticals, agrochemicals, and materials. N-Heteroarynes provide a scaffold to build these essential molecules but are underused because five-membered...
24
83
529
17 years in the making.. We are super excited to finally achieve alcohol-alcohol cross-coupling enabled by the powerful SH2 radical sorting! Great work Jerry, Nick, Jay, James, Colin and Robert. Big shout out to our collaborator Jesus from Janssen Spain. https://t.co/PRi5bjqkJL
17
117
817
Thrilled to share that our paper on 1,3,2-diazaphospholene-catalyzed asymmetric Claisen rearrangement is now online in @ScienceMagazine . Check out the big step forward in DAP catalysis. https://t.co/lvu7SIiXWl
science.org
A phosphorus-based catalyst produces quaternary carbon stereocenters with high enantioselectivity.
9
27
131
Asymmetric #Synthesis of Cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor by Hao Shao, Wenheng Liu, Muhan Liu, Haibing He, Qi-Lin Zhou, Shou-Fei Zhu, and Shuanhu Gao in @J_A_C_S
https://t.co/n7gepBao0D
0
23
94
CYCLOPAMINE! A total synthesis with LEO Pharma collaborators. Appearing today in @ChemRxiv : https://t.co/u8y2RMQsPy
5
35
228
Divergent #TotalSyntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization by Pengfei Fu, Tao Liu, Yang Shen, Xin Lei, Tianjie Xiao, Peng Chen, Dongsheng Qiu, Zhen Wang, and @YandongZhang16 at Xiamen University in @J_A_C_S
https://t.co/ugMNw0VdiH
0
24
111
❇️ In this Synfact of the month Martin Oestreich (@Silicon_Martin) highlighted the ´An Electroreductive Approach to Nickel-Catalyzed Enantioselective Cross-Coupling of Aryl Aziridines` by Nevado C. and co-workers from @UZH_en.😀 👉 https://t.co/7x0N15GeLn
1
6
19
Our third total synthesis work this year is now out in @J_A_C_S. Congrats to all the team members!
#TotalSynthesis of (−)-Retigeranic Acid A: A Reductive Skeletal Rearrangement Strategy by Dongyu Sun, Ruyi Chen, Dongmin Tang, Qidong Xia, Yifan Zhao, Chun-Hui Liu, and Hanfeng Ding @HanfengD at @ZJU_China in @J_A_C_S
https://t.co/973XHHC2Iz
6
10
158
Total Synthesis of (±)- and (−)-Daphnillonin B @CHNSci @TotalSynthesis @TotalSyntheses #Totalsynthesis #NaturalProducts #PausonKhand #Metathesis #WagnerMeerwein #Rearrangement
pubs.acs.org
The first total synthesis of (±)- and (−)-daphnillonin B, a daphnicyclidin-type alkaloid with a new [7-6-5-7-5-5] A/B/C/D/E/F hexacyclic core, has been achieved. The [6-5-7] B/C/D ring system was...
0
18
101
#TotalSynthesis of Diverse Tetramic Acid Bearing cis-Decalin Natural Products (Xiaoguang Lei and co-workers) @PKU1898
https://t.co/GAqyThUtag
0
3
10
Base-Promoted Electrochemical CoII-catalyzed Enantioselective C-H Oxygenation (Bing-Feng Shi and co-workers) #AngewandteVIP
https://t.co/Par3eliDCF
0
1
27
Tired of buying Ni(COD)2? Now you can quickly electrogenerate it using an ElectraSyn 2.0! A fruitful collaboration with @EngleLab, @BaranLabReads and BMS brilliantly conducted by @CamZRub that appeared today @ChemRxiv. https://t.co/qYEEeLMpDp
7
47
285
Reductive Asymmetric Aza-Mislow-Evans Rearrangement by 1,3,2-Diazaphospholene Catalysis (Cramer) @GuotingZhang @EPFL_CHEM #openaccess
https://t.co/z2WYm6hxqj
1
5
23
Ni-Cat Enantioselective Electrochemical Cross-Coupling: Aryl Aziridines & Alkenyl Bromides @NevadoLab @UZH_Science @UZH_Chemistry @TotalSyntheses #Ni #Catalysis #Enantioselective #Electrochemistry #Reuctive #CrossCoupling #Aziridine #Alkenylbromide
pubs.acs.org
An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl homoallylic amines...
1
20
93
Excited to see our latest work in the area of DAP catalysis now available on @angew_chem ! Reductive Asymmetric Aza‐Mislow‐Evans Rearrangement by 1,3,2‐Diazaphospholene Catalysis
onlinelibrary.wiley.com
A 1,3,2-diazaphospholene-catalyzed three-step cascade transformation of chiral N-sulfinyl acrylamides comprised of a conjugate reduction, enantiospecific [2,3]-sigmatropic aza-Mislow-Evans rearrang...
0
0
5
Congratulations to @jordiduran6 for a titanic effort! His first PhD work is out in @ChemRxiv, focusing on the Catalytic Asymmetric Defluorinative construction of alpha-Allyl Ketones. Kudos also to @javiml_94 @UniBarcelona @QuimicaUB Check it out here 👉 https://t.co/5IkNH6wj1e
3
20
126
Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale @Wiley_Chemistry @wileyinresearch @WileyEngineer @wileyeng @isciverse @Innov_Materials @InnovationChem @CHNSci @NatProducts
https://t.co/MHp0F7iR7w
2
14
74
#NHCs #NHeterocyclicCarbenes Trost group reported new #bifunctional ligands bearing #chiral #NHC & #prolinol. Application in #Zn-#Cu catalyzed asymmetric #allylic alkylation. Simultaneous #coordination of two different metals! @pengcheng_gao @ChemEurJ
https://t.co/ZWJNtA9UOx
0
5
19