Gladfelter Lab
@GladfelterLab
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Scientists using microscopes, math, physics and fun to discover how cells work. Please follow us at https://t.co/w5xCc1eh1C
Duke Cell Biology/BME
Joined July 2019
The mysteries of septins continue to unfold in this study examining mechanisms of septin polymerization and assembly
biorxiv.org
Cells employ cytoskeletal polymers to move, divide, and pass information inside and outside of the cell. Previous work on eukaryotic cytoskeletal elements such as actin, microtubules, and intermedi...
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We are excited to share our next installment of insights into how septins sense micron-scale curvature via detecting lipid packing
biorxiv.org
Septins assemble into scaffolds that direct cell growth and morphology that are often localized to the plasma membrane. While septins preferentially bind convex membranes via amphipathic helices,...
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Bye bye twitter 👋 hope to see everyone on BlueSky!! @gladfelterlab.bsky.social
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Excited to share our recent work on the power of RNA to encode physical information and how this can be embedded in the genetic code
biorxiv.org
Most amino acids are encoded by multiple codons, making the genetic code degenerate. Synonymous mutations affect protein translation and folding, but their impact on RNA itself is often neglected. We...
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Excited to share the latest work from postdocs @turiyaaa and Zack! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs.
Condensates act as translation hubs to coordinate multinucleate cell growth https://t.co/09q9Y7KKad
#biorxiv_cellbio
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Excited to share our first publication on the placenta in close collaboration with our colleagues in the Coyne Lab. This work led by @madkeenen reveals remarkable nuclear heterogeneity arising in a common cytoplasm of the syncytiotrophoblast cell.
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Register here: https://t.co/XO3RCcrEpN for the 13-16 April 2025 Lisbon. Please join us!
meetings.embo.org
The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…
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Announcing the EMBO-funded workshop on Integrating Cell and Planetary Scales to Address Climate Resilience! We are gathering experts working from single molecules to cells to ecosystems to discuss cell-based discovery and solutions for climate change challenges.
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Team Placenta is excited to be in Montreal at #IFPA2024! Looking forward to @madkeenen's new investigator award lecture🤩 then her & @vfarm15 have posters in session two-check them out!
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We are back! This year's TCM will be held on September 23rd. Our wonderful lineup of speakers includes keynote Kassandra Ori-McKenney (UC Davis), Ronit Freeman (UNC), and Shashank Shekhar (Emory Univ). @RFreeman_Lab @sshekhr
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📣 Join us @ASCBiology @EMBO meeting in December on this session on Harnessing Cell Biology to Address Climate Resilience. Submit your Abstract by 5th Aug. With @GladfelterLab @SamReckPeterson @Dey_Gautam. Please RT
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This mechanism brings hope for routes to adaptation in climate change but also shows how readily new pathogens may arise!
medschool.duke.edu
New research reveals shape-shifting proteins may help some organisms, like plants, adapt to rising temperatures. But this same ability could also lead to the emergence of dangerous fungal pathogens
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Our newest paper in Current Biology demonstrates how small changes in a disordered protein sequence enable fungi to grow at different temperatures. @1stLinesSci
cell.com
Using Ashbya gossypii isolates from diverse climates, Stormo et al. find temperature-sensitive defects in the nuclear division cycle and morphogenesis. These phenotypes are associated with changes in...
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Very excited to share our first paper analyzing giant syncytial cells of the human placenta! This work would not be possible without our wonderful colleague Carolyn Coyne. Amazing work @madkeenen
biorxiv.org
The outer surface of chorionic villi in the human placenta consists of a single multinucleated cell called the syncytiotrophoblast (STB). The unique cellular ultrastructure of the STB presents...
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Submit your abstract to be part of this exciting subgroup!
I am super excited to announce that @madkeenen and I are co-organizing a special interest subgroup at this year's ASCB (in San Diego!) on all things multinucleate. Spread the word, and send in abstracts by August 6th! Reach out to us with any questions.
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Registration for the 2024 TCM will open on July 22! We encourage all cytoskeleton enthusiasts to submit an abstract for talks and poster presentations. Registration fees and important dates are listed below. #cytoskeleton #ResearchTriangle #NCTriangle
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Check out our latest pre-print by Grace Hamilton which explores the biochemical properties of a group 5 septin from the polyextremotolerant yeast Knufia petricola
biorxiv.org
Morphological complexity and plasticity are hallmarks of polyextremotolerant fungi. Septins are conserved cytoskeletal proteins and key contributors to cell polarity and morphogenesis. They sense...
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Thrilled to start this incredible adventure! #MBLPhysiology @MBLScience
So excited to be getting started in this year's Physiology Course @MBLscience #mblphysiology. Already an amazing start of our first year Directing the course with Amy @GladfelterLab
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Learn about the amazing and mysterious world of marine fungi and all they are doing to help the planet!
academic.oup.com
When researchers pulled up the piece of wood—a log from a tree called ubame oak—it had spent 1302 days on the bottom of the ocean. A pretty deep bottom of
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