Bret Freudenthal
@Freudlab
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Professor studying the interplay between DNA damage and human health. WY➡️CSU➡️UI➡️NIEHS➡️KU. Personal tweets from science to society.
Kansas City, MO
Joined December 2017
New PI Lesson #508 - be very clear when providing the title of your seminar. 🤦♂️ #needmoresleep #sicktoddler
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🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing! https://t.co/Kb3zoEKarm
docs.google.com
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Please, #cryoEM community (and @ImagingArtifact), we need some help to identify some objects in our 2D averages. Probably, contaminants from e coli recombinant protein production. Any idea?
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November Spotlight: Kerri Dean-Executive Assistant Kerri recently celebrated her 6th year as Executive Assistant to the Chair of the Cancer Biology Department at the University of Kansas Medical Center (KUMC). Her journey at KUMC began in the Medical Oncology Department, where
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🎉 Joint paper from the Freudenthal and Weaver Labs! @abbey_vito first author publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability. Built on Tyler's foundational work! https://t.co/T1JrdIg3r2
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🎃 Happy Halloween from the Freudenthal Lab! 🐟🖤 Anglerfish PI + Emo Researchers = Bioluminescent Despair #Scienceunderpressure
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One of my favorite lab activities is our annual pumpkin carving competition with the Bose Lab. Everyone did a great job with their pumpkins!
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Excited to share our latest paper: implications for LRRK2 biology across clinically distinct neurodegenerative diseases
pubmed.ncbi.nlm.nih.gov
Parkinson's disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present...
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Meet Dr. Aninda Dey, a postdoctoral fellow whose research focuses on oxidative DNA damage and its role in cancer. As a @KUcancercenter trainee member, Dr. Dey is gaining valuable mentorship and expanding his skillset. Learn more ➜ https://t.co/3lOI9dGrWP.
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The Sangre de Cristo Mountains outside Santa Fe were beautiful today!
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Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing
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Sad to just learn of the passing of Phyllis Strauss
dignitymemorial.com
Celebrate the life of Phyllis Strauss, leave a kind word or memory and get funeral service information care of Stanetsky Memorial Chapel.
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Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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How it started: Assistant to the Professor 👨🔬✨ How it’s going: Professor mode unlocked 👨🏫 Also clear evidence that science doesn’t just build knowledge… it ages ya too 😉 🙏Grateful to all the mentors, colleagues, trainees, friends & family who made this journey possible.
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Please RETWEET 😞
If you think a golden ballroom is more important than childhood cancer research… I have nothing left to say to you.
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Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to @kaitlindehart and all the co-authors! Check it out:
jbc.org
Apurinic/apyrimidinic (AP) sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during base excision repair. The enzyme apurinic/apyrimidinic endonucle...
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