Emilio Lecona
@Emlecona
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Scientist attached to chromatin, full time father, amateur foodist with a sweet tooth and always a dreamer.
Madrid, España
Joined March 2015
Still some time to apply!
We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
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Congrats Alicia on the best poster prize in the PhD & Postdoc Annual Meeting @CBM_CSIC_UAM Very proud of you! Many more successes to come!
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We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
Aprobada la convocatoria Juan de la Cierva 2025 (#JDC2025) para fomentar la incorporación de jóvenes doctores/as y completar su formación postdoctoral en centros de I+D. ▶️500 ayudas 💵60 M€ (+21,7 M€ que 2024) 📅Plazo: 25 nov-10/17 dic 2025 📰 https://t.co/lA3HGPYM8w
#FSE+
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If you are interested in understanding how DNA replication works, here we are!
We are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva 2025 call, to join our lab at the @CBM_CSIC_UAM to work on the interplay between the ubiquitin pathway, DNA replication and the replication stress response.
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We had a great workshop today!
We are very happy with the @GenomaHubCSIC Workshop on "Genome dynamics from development to disease" hed at our institute. Organized by @NestorGarRod , @HombreRRo , @Lab_GonAguilera and X-less Belén Gómez-González
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We are very happy with the @GenomaHubCSIC Workshop on "Genome dynamics from development to disease" hed at our institute. Organized by @NestorGarRod , @HombreRRo , @Lab_GonAguilera and X-less Belén Gómez-González
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Un placer y un privilegio formar parte de esta mesa redonda dentro de las celebraciones del #CincuentenarioCBM.
💬 Cerrando el primer día del simposio del #CincuentenarioCBM: mesa redonda sobre el futuro de la Biología Molecular en Europa, moderada por Patricia Fernández de Lis y con Ángela Nieto, Crisanto Gutiérrez, Aurelio Hidalgo, Laura Formentini y Emilio Lecona.
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Hoy hemos acompañado al @CBM_CSIC_UAM en la celebración de su 50 aniversario – Jubileo de Oro, un centro de referencia internacional en investigación biomédica al que estuvo profundamente vinculada nuestra Margarita Salas. #CincuentenarioCBM
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We are so happy to share that our latest paper is finally out in @NatImmunol! 🤩 There’s a lot of work and passion behind this discovery of the preTCR as a novel #immunotherapy target for T-cell acute lymphoblastic #leukemia (T-ALL). 🔬🩸 https://t.co/ueNfwH5oPp
@Nature
nature.com
Nature Immunology - The authors identify pre-TCR as a key biomarker and therapeutic target in T-ALL. Targeting it with an anti-pTα antibody–drug conjugate inhibits leukemia-initiating...
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Still looking! Please spread the word.
We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.
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We are looking for a candidate to apply to a #MSCA Postdoctoral Fellowship in our lab in the @CBM_CSIC_UAM, working on the connections between DNA replication dynamics, replication stress and genomic instability in cáncer. Contact us if you are interested and please retweet.
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New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @CellReports. Congratulations to first author Antonio Galarreta and to all co-authors. https://t.co/WE2QHsIs0S.
#Microscopy #RNAiScreen #Condensates
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Muchas gracias por destacar nuestro trabajo en el @UbiSystemLab liderado por @rodrimartinr y en colaboración con @SaraRodriguezAc en el @JMendez_DNA lab.
Avance clave desde el @CBM_CSIC_UAM , donde trabajó Margarita Salas: descubren un mecanismo que regula cómo se copia el ADN y evita errores durante la replicación. #Ciencia #CBM #Replicacion #ADN
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Fresh from the oven! Ever wondered how cells keep ATR activation controlled during normal DNA replication? Our last paper in @NatureComms shows that they do it by extracting POLA/PRIM from chromatin using VCP/p97! Still curious? Take a look...🧵🧵🧬🧬
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Very proud of the work of @SaraRodriguezAc and @rodrimartinr that has led us to discover how VCP/p97 connects priming during DNA replication and the replication stress response. Thanks to all the team and a great collaboration with @JMendez_DNA .
El grupo de Emilio Lecona @Emlecona descubre un mecanismo que controla el sistema de alarma durante la replicación del material genético 🧬 El hallazgo abre posibilidades para desarrollar nuevas estrategias contra el cáncer. https://t.co/qGpzrjJD8a
@CSIC @UAM_Madrid
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@CBM_CSIC_UAM @Emlecona El estudio, dirigido por @Emlecona (CBM), se publica en @natcomms, con @SaraRodriguezAc (CNIO) y @rodrimartinr (CBM) como primeros autores, y la colaboración del grupo de @JMendez_DNA (CNIO). https://t.co/NnWHKVTCBB
nature.com
Nature Communications - The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex...
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@CBM_CSIC_UAM @Emlecona The study, led by @Emlecona (CBM), is published in @natcomms, with @SaraRodriguezAc (CNIO) and @rodrimartinr (CBM) as first authors, and in collaboration with @JMendez_DNA’s group (CNIO). https://t.co/NnWHKVTCBB
nature.com
Nature Communications - The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex...
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El grupo de Emilio Lecona @Emlecona descubre un mecanismo que controla el sistema de alarma durante la replicación del material genético 🧬 El hallazgo abre posibilidades para desarrollar nuevas estrategias contra el cáncer. https://t.co/qGpzrjJD8a
@CSIC @UAM_Madrid
cbm.uam.es
Investigadores del Centro de Biología Molecular Severo Ochoa (CBM, CSIC-UAM) han identificado un mecanismo que permite a las células copiar su ADN de manera segura y ordenada. Esto permite comprender...
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Credit to @rodrimartinr and Sara Rodríguez Acebes for their outstanding work.
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Our work is already online!
Just published! Lecona & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication VCP/p97 = checkpoint gatekeeper! Read the full article: https://t.co/GcZLfEvmyY
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