Aliza Ehrlich, PhD
@EhrlichAliza
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Neuroscientist studying GPCR signaling in neuronal primary cilia related to psychiatric disease.
San Francisco, CA
Joined December 2020
The neural circuits and signalling pathways of opioid use disorder — a Review by Victor P. Mathis, Aliza T. Ehrlich & Emmanuel Darcq @Victor_Mathis_ @EhrlichAliza @EDarcq
https://t.co/kM7L5m7cWB
nature.com
Nature Reviews Neuroscience - In many parts of the world, opioid use disorder presents a growing challenge to public health, reinforcing the need to decipher its underlying mechanisms. Mathis et...
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Thank you @NatRevNeurosci for highlighting our recent review on the neural circuits and signaling pathways driving opioid use disorder!
The neural circuits and signalling pathways of opioid use disorder — a Review by Victor P. Mathis, Aliza T. Ehrlich & Emmanuel Darcq @Victor_Mathis_ @EhrlichAliza @EDarcq
https://t.co/kM7L5m7cWB
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We are excited to share our latest review article published in Nature Reviews Neuroscience! It was a pleasure to collaborate with fantastic colleagues @Victor_Mathis_ and @EhrlichAliza We discuss the neural circuits and signaling pathways driving OUD. https://t.co/2wrSlA1Lln
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Congratulations @xinduan Kushal@UC Berkeley and coauthors on the @NeuroCellPress paper molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma!
A @NeuroCellPress paper led by Kushal @UCBerkeley, Nicole&Victoria @UCSF in full collaboration with @shekharlab, Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma https://t.co/QjeNMbQwWZ
#retina #MERFISH
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Joy Li, a Postdoctoral Scholar at @UCSFMedicine, is the April 2025 Highlighted for MolPharm. Her research is part of an ongoing body of work to understand how different drugs exert selective effects on cells and organisms: https://t.co/pBzSGycnq7
#GPCR #endocytosis #cellbiology
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In an unprecedented move, the US National Institutes of Health has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”. https://t.co/ALQlFtfuVd
nature.com
Nature - Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
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About a month after Donald Trump took office as the 47th US president, almost all grant-review meetings remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion
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Appreciate this generous write up on our recent preprint! https://t.co/qq0HUCJfXK
thetransmitter.org
The finding may help explain autism’s association with multiple co-occurring conditions that involve cilia defects.
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Haruki Nakamura brings his artwork to life through the time-honored tradition of paper crafting. Using paper engineering, he constructs whimsical creatures and dolls that move in surprising ways. https://t.co/o5Ej3xIJjq
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@SilvioGutkind and I are looking forward to seeing you all at the 2025 GRC in Molecular Pharmacology. Please apply for short talks. We are interested in applications from historically marginalized groups, e.g., @BlackWomenSTEM, @500QueerSci, @DisabledSTEM
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Our work establishing the mu opioid receptor as a cilia localized receptor in native neurons is published @CellReports! Congratulations @RitaFagan, David Lee, Matan Geron, Gregory Scherrer and Mark von Zastrow. For details
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Scientists unveil the first complete cell map of a whole mammalian brain! This cell atlas characterizes over 32 million cells across the mouse brain. The NIH #BRAINInitiative-funded findings advance our understanding of human brain function and diseases. https://t.co/g5BPXMEbwq
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Our paper characterizing β-arrestin-independent endosomal cAMP signaling is now out!
nature.com
Nature Chemical Biology - This study reveals β-arrestin-independent GPCR signaling via the cAMP pathway from endosomes, and it delineates a discrete function of β-arrestin in temporally...
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Our recent work on Tianeptine characterization is out! Congrats @FlorenceAllain @EhrlichAliza and @MDMcNicholas and others 🥳!
New Research: Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice: Introduction Tianeptine is approved in some countries to treat depression and anxiety. In addition to its activity… #Psychiatry
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Out today! Congratulations @Michel_Bouvier
@sschamiloglu @NeuroBender Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice
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It's the last day at SFN but we've been saving the best for last! Check out posters D30 @RitaFagan in the am and C33 in the pm to discover how cool neuronal cilia are #SfN22
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Our work revising a fundamental mechanism of β-arrestin action is out today in @eLife: https://t.co/xHkrLBFbcz! An amazing finding by @BarsiBen (co-mentored with Mark von Zastrow), who doggedly pursued a simple but powerful observation that challenges the textbook model.
elifesciences.org
Two modes of GPCR endocytosis by β-arrestin are differentially coupled to downstream signaling.
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Our work on Gpr88 is finally out :) The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder https://t.co/UA9z8t102n
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Excited to share my preprint on β-arrestin-independent endosomal signaling by VIPR1:
biorxiv.org
The ability of GPCRs to initiate a second phase of G protein-coupled signaling after endocytosis is now well established. The prevailing current view is that GPCR signaling from endosomes is strictly...
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