Dr Denis Hartmann
@DenisHartmann
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Current Postdoc in the TAB-Lab at UoB. Former Oxford DPhil Student in the Booth group, Wolfson College, Bassoonist, Austrian, gamer, book-lover. he/him, 🏳️🌈
Oxford, England
Joined December 2011
More of my postdoc work has now been published in @ChemEurope. This was a super fun project to work on, and with lots of diverse and challenging synthesis, characterisation, crystallography and DFT!
📰 The study of a homochiral perylene diimide dimer for sensing chiral anions is now out in @ChemEurope. Work led by Denis @DenisHartmann with contributions from previous MSci and MRes students Lucy and Jamie in the TAB-Lab @TabLabChem
https://t.co/lrkjZtn977
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A Bis-Perylene Diimide Macrocycle Chiroptical Switch (Timothy A. Barendt and co-workers) @DenisHartmann @TabLabChem @UoBChemistry @ZwijCompChem #openaccess 🔓
onlinelibrary.wiley.com
A chiral bis-perylene diimide macrocycle has been prepared in which point chiral imide groups yield a discrete helical dimer, to mimic a helical supramolecular assembly. The macrocycle exhibits...
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My first major piece of postdoc work in @TabLabChem is finally out in @angew_chem. 🎉
A new chiral macrocycle which shows three-way switching of its chiroptical properties out now @angew_chem. Work by @DenisHartmann in @TabLabChem & fantastic collaborators @SamuelPenty and Robert Pal at @DurhamChemistry and @ZwijCompChem at @UCLChemistry
https://t.co/Yw5eqZiSik
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Starting off our second day with @DenisHartmann from @TABarendt talking about PDI macrocycles for molecular electronics and host-guest chemistry! #ECRMASC2024
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My PhD work has made it into @SynCellEU 🥳
@DrMikeBooth and his team at @UCLChemistry have developed a method to turn gene expression on or off using multiple wavelengths of light. A promising technique to study complex cellular processes and advance #syntheticcell #research and #technology! More: https://t.co/yvD99iG4TT
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Two of my PhD papers are now published back-to-back in @J_A_C_S! I really enjoyed working on those two projects, do go and give them a read 😁
Exciting 📢! Our two @J_A_C_S articles have now been published back-to-back in the same issue 😍😍😍! @DenisHartmann @Jack_Mazzotti @UCLChemistry @OxfordChemistry @OxfordSynthesis #DNA #ASO #synbio #cellfree #syntheiccell #photocage
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And this is my last paper from my PhD published! 🎉
Another @J_A_C_S paper from the group! We generated synthetic cells containing logic gates that can be *spatiotemporally patterned* with two orthogonal wavelengths of light! Led by @DenisHartmann @JeffersonMSmith @Razia_C @OxfordChemistry @UCLChemistry
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We made *orthogonally* light-activated antisense oligonucleotides as precise switches for cell-free systems 🔦🧬 Published in @J_A_C_S 🤩! Led by @Jack_Mazzotti @DenisHartmann @OxfordChemistry @OxfordSynthesis @UCLChemistry #DNA
pubs.acs.org
Cell-free expression of a gene to protein has become a vital tool in nanotechnology and synthetic biology. Remote-control of cell-free systems with multiple, orthogonal wavelengths of light would...
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We've topologically constrained antisense oligonucleotides into a handcuff structure, via photocages, to control gene knockdown! Published in @ChemCommun, led by @DenisHartmann
@OxfordChemistry @OxfordSynthesis @UCLChemistry #supramolecular #ASO
https://t.co/s8T1JmKIIF
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.@DrMikeBooth, @DenisHartmann and co. report photocaged antisense oligonucleotides to knockdown cell-free protein synthesis using light. @UCLChemistry @OxfordChemistry @OxfordSynthesis @UCLChemLight
https://t.co/zMdzZneXgM
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Great work by our very own @DenisHartmann out now in @CommsChem!
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We’ve developed light-activated antisense oligonucleotides by conjugating photocages to phosphorothioates 🤩🧬🔦! Published in @CommsChem, led by @DenisHartmann @OxfordChemistry @OxfordSynthesis @UCLChemistry #ASO #DNA #light
nature.com
Communications Chemistry - Light-activated antisense oligonucleotides have been developed to induce gene knockdown in living cells, however, their synthesis remains challenging and application in...
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@EPSRC We've got *2* EPSRC PhD opportunities to join our group in London to study the chemistry and application of nucleic acids, photocages, and polymers! 😍🧬🔦🌡️🧪 https://t.co/JcE4XGWf3O
📢 TWO new PhD positions 📢 Join my group in London to work on controllable nucleic acids for biology and medicine! 🧬🔦🌡️🔊🧫🧪😍 @UCLChemistry Deadline 26th Jan 2023 / Start date Oct 2023 Details in below 🧵
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One of my DPhil projects with @DrMikeBooth is now on chemRxiv! We developed light-activated antisense oligonucleotides by photocaging the backbone and could use that to control gene knockdown in cell-free expression! Have a look below! @OxfordSynthesis @OxfordChemistry
We've developed light-activated antisense oligonucleotides by conjugating photocages onto phosphorothioates 😍🧬🔦! We used these as cell-free expression OFF switches 🧪🛑⚡️! Preprint from @DenisHartmann
@OxfordSynthesis @OxfordChemistry @UCLChemistry
https://t.co/PKSYtFuphE
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If you are curious what I spent a large part of my DPhil on so far, my project on blue light-activatable DNA is now available on ChemRXiv as a preprint! 🎉 @OxfordSynthesis @OxfordChemistry
We’ve developed blue light-activated DNA! We used it to create the first dual light-activated cell-free logic gate 🤩🧬⚡️🧪 Preprint led by incredible student @DenisHartmann
@Razia_C @JeffersonMSmith @OxfordSynthesis @OxfordChemistry @UCLChemistry
https://t.co/CsPiCYL9Fw
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We’ve engineered light-activated communication between synthetic cells and living cells! 🧬⚡️🧫 Check out our preprint, led by my amazing student @JeffersonMSmith
@DenisHartmann @SynBioCDT @OxfordChemistry @UCLChemistry @SynCellEU @buildacell
https://t.co/sX0uSWxhUq
biorxiv.org
Gene-expressing compartments assembled from simple, modular parts, are a versatile platform for creating minimal synthetic cells. In a manner synonymous with natural cells, these life-like assemblies...
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My poster is now up at the #Biochemistry2022 conference in Münster! Come have a look and chat to me (in 🇩🇪 or 🇬🇧) about blue-light controllable DNA, done under supervision of @DrMikeBooth as part of @OxfordSynthesis. It is nice to have in person events again! 🎉
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Preparing for a conference presentation with the smallest ironing board ever to iron the fabric poster 🎉
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📢 4th Edition of @RoySocChem Nucleic Acids in Chemistry and Biology has now been released (Blackburn/Gait/Egli/@jwattsgroup) – The bible for scientists who work with nucleic acids Furthermore, I wrote the revamped chapter on DNA and RNA Sequencing! 🥳 https://t.co/1HJFDZ0CU3
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Come and watch this! My PhD work is featured! 🎉
Happening today ⏰⏰⏰
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