The Dénes Lab
@DenesLab
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Let's kick off with this week with #microglia: in our latest @NatureComms paper, we show how microglia fundamentally influence neuronal properties in ex vivo acute slices https://t.co/89uogujanX
nature.com
Nature Communications - Microglia undergo rapid phenotype changes in response to tissue disturbances but the impact of these changes on neuronal networks is unclear. Here, the authors show that...
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Out now in @natcomms : parvalbumin-expressing neurons of the diagonal band of Broca mediate learning from negative experiences https://t.co/OxDRcnzoaD Congratulations Panna Hegedüs, @kiraly_b, Dániel Schlingloff!
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Adam is just about to flood us with information about compartment-specific neuronal and vascular modulation by #microglia at the #FENS-Hertie Winter School @FENSorg @DenesLab
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We are happy to share the newest results of our lab elaborating on the essential role of somatic junctions during development. Paper now now out in @CellReports
https://t.co/fg3dIJFIaz Brief summary:
eurekalert.org
The Laboratory of Neuroimmunology of the Institute of Experimental Medicine, Budapest (IEM), Hungary, led by Ádám Dénes, describes the presence of a direct interaction site between microglial cells...
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Rapid microglial phenotype changes modulate neuronal networks and sharp wave-ripple activity in acute slice preparations https://t.co/uuMoU1wd8j
#biorxiv_neursci
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We conclude a wonderful @EMBO Stroke-Immunology Workshop in Munich! Many thanks to all the speakers and participants for their contributions and discussions.
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Our new paper by Császár, Lénárt et al., is out in @JExpMed showing that #microglia modulate cerebral blood flow, neurovascular coupling and adaptation to hypoperfusion via dynamic, purinergic actions in the #NVU. https://t.co/aP1lALVxrq
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New paper out in @PLOSBiology elaborating on the importance of the NKCC1 transporter in microglial physiology and inflammatory responses. Central vs systemic blockade of NKCC1 with bumetanide have opposite effects. Great team effort led by @KrisztinaTth6
https://t.co/ZfEjH8rkRv
journals.plos.org
This study shows that inflammatory responses of microglial cells are markedly influenced by the ion transporter, NKCC1; blockade or genetic deletion of microglial NKCC1 has broad cell-autonomous...
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Many thanks to all speakers and participants who contributed to the Stroke-Immunology meeting. Great talks, inspiring data, stimulating discussions - see you all next year!
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I am very happy to share this piece of review from @Deneslab, @csaba_cserep and me with all microglia-enthusiasts! https://t.co/TJ92FoNTqx
@NeuroCellPress #microglia
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Huge success! Our paper on somatic microglia-neuron junctions has been honored with the annual Outstanding Paper Award from @eurmicsoc Join us in congratulating all the authors! https://t.co/8gp0gWOgdH
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A brilliant piece of perspective from Axel Nimmerjahn on microglia-neuron somatic junctions https://t.co/XLtlA9qLFT Also, our paper reached its final form: https://t.co/8gp0gWOgdH
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Some of our latest results are included in this newly released paper: Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain https://t.co/qGO05aKgc6 We really enjoyed working together, and huge congratulations @DanielP_Varga
journals.sagepub.com
Selective elimination of microglia from the brain was shown to dysregulate neuronal Ca2+ signaling and to reduce the incidence of spreading depolarization (SD) ...
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New paper out: we show that microbial short-chain fatty acids improve neuroplasticity and functional recovery after stroke. Effect is mediated by brain-invading T cells on microglia. https://t.co/ub9z3sYYpK
@rebeccaksadler @SfNJournals @JNeuroscience
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Our paper has been picked by @sciencemagazine for first release! Microglia monitor and protect neuronal function via specialized somatic purinergic junctions https://t.co/0oWFStvzVU We are extremely grateful for the hard work and utmost help of everybody involved!
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Today is #WorldStrokeDay ! Stroke is the second leading cause of death. 1 of 4 of us will have a stroke! Besides better prevention, we must increase our efforts for a better mechanistic understanding of this disease and develop novel therapies @ISD_Research
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I want express my sincere gratitude to the organizers and program committee of @brain_2019, to @ISD_Research @LieszLab and all the kind congratulators for being honored with the Niels Lassen Award!
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From our lab we had two beautiful study presented by @BekyBlack @csaszar_eszter at the Brain meeting in Yokohama. Expect to hear more at the first stroke immunology meeting next year in Münich!
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