Avraz Anwar
@Avraz__Anwar
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Organic chemist| Welter family fellow| NIH T32 fellow| B.S Biochemistry ‘19 MTSU| M.S Chemistry ‘21 MTSU| Ph.D Chemistry ND in the Del Valle lab
South Bend, IN
Joined September 2020
RT @DelValleLab: Check out this Just Accepted paper from @Avraz__Anwar describing a streamlined synthesis of N-amino peptides. This genera….
pubs.acs.org
We report an optimized protocol for the solid-phase synthesis of backbone-N-aminated peptides. Electrophilic N-amination of amino acid zwitterions provides crude α-hydrazino acids that can be used...
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My latest publication is now online in @JOC_OL ! Since developing this protocol, our lab has significantly reduced organic solvent usage (>20x less EA) saving us thousands of dollars and lots of time.
pubs.acs.org
We report an optimized protocol for the solid-phase synthesis of backbone-N-aminated peptides. Electrophilic N-amination of amino acid zwitterions provides crude α-hydrazino acids that can be used...
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I am grateful to be recognized as a Next Gen Leader in Chemistry by @Merck ! I look forward to meeting with the scientists who continue to inspire me by their wonderful research and leadership. A huge thanks goes to @DelValleLab for outstanding mentorship and support.
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Now live on ChemRxiv! We've developed a new approach that enables us to synthesize N-amino peptides in a fraction of the time compared to previous methods. By optimizing cleavage conditions, we eliminated many byproducts, resulting in highly pure peptides.
I am so excited to present my data in group meeting tomorrow that I can’t sleep. This data will have such an enormous impact for our lab, relieving a LOT of synthetic burden while also yielding incredibly pure peptides! A very fun process chem side project :).
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I am so excited to present my data in group meeting tomorrow that I can’t sleep. This data will have such an enormous impact for our lab, relieving a LOT of synthetic burden while also yielding incredibly pure peptides! A very fun process chem side project :).
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RT @organomimetic: Regardless of whether you think this metric is the best proxy for measuring true science impact, US academics and more i….
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RT @DelValleLab: Congrats to @Avraz__Anwar, whose total synthesis of marformycins A&D appeared in in @JOC_OL! Special thanks to Yassin and….
pubs.acs.org
We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A (1) and marformycin D (2) using a solid-phase approach. A scalable solution-phase synthesis of the γ-hydroxypiperazic...
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RT @Shenvi_Lab: If you like total synthesis and Wordle, check out Synthordle, a retrosynthetic analysis game created by Shenvi Lab associat….
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RT @DrTedros: Timely and concerning data from @TheLancet. Drug-resistant infections know no borders. Every country is at risk. The respons….
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Me weighing out DCC.
What material do you believe this to be?.
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Amazing to see efforts to combat antimicrobial resistance is making a comeback in big pharma. Great job @EliLillyandCo.
.@EliLillyandCo has partnered with @OpenAI, maker of the generative #AI platform ChatGPT, to invent new #antibiotics:
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RT @BMorgan_Chemist: The #MorganLabatND celebrated Johann Roque yesterday! He received the Chemistry-Biochemistry-Biology Interface Trainin….
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RT @asymtmm: Excited that the story of Merck’s Ph 3 oral PCSK9 inhibitor, told by my friend and colleague @dthaisrivongs at #NOS2023ND, is….
organicdivision.org
The NOS 2023 Introduction given by co-SEOs Michelle Tran-Dubé & Steven Silverman along with local organizers: Olaf Wiest & Juan Del Valle.
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RT @DelValleLab: At last. we're thrilled to send our story on macrocyclic mini-tau seeds out into the world. Organic chem, protein mimicr….
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I am excited to share that my most recent publication was selected to be the front cover of @ChemMedChem!.
#OnTheCover Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide-Modified Analogues (ChemMedChem 1/2024) (J. R. Del Valle et al.) @DelValleLab
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RT @stats_feed: Largest pharma companies by market cap:. 🇺🇸 Eli Lilly: $581b.🇩🇰 Novo Nordisk: $449b.🇺🇸 J&J: $355b.🇺🇸 Merck: $259b.🇺🇸 AbbVie….
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Had an amazing time at the Purdue University Notre Dame Symposium (PUNDS). There were so many great talks/research being done from each university. With that being said, I am honored to receive the Best Presentation Award for my talk!
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RT @DelValleLab: Excited to share our story on cross-beta epitope mimics targeting tau propagation, out now in @J_A_C_S. Grateful to all in….
pubs.acs.org
The aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of Alzheimer’s disease (AD) and related tauopathies. Disease-associated conformations of filamentous tau are...
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Happy to share my recent publication is highlighted in @ChemistryViews!.
chemistryviews.org
Modified analogues as promising starting points for drug development
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