David Konrad
@DavidBKonrad
Followers
1K
Following
3K
Media
29
Statuses
355
Tenure-Track Professor @univienna & Group Leader @LMU_Muenchen. Cancer Chemical Biology, (Chemo)Proteomics, Medicinal Chemistry and Chemical Methodology.
München, Bayern
Joined January 2019
The Chemistry and Biology of the Tetrodotoxin Natural Product Family (David B. Konrad and co-workers) @DavidBKonrad #AngewandteReview #openaccess 🔓
onlinelibrary.wiley.com
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7...
0
3
12
Big thanks to our co-authors from academia: @fra_grisoni, @DirkTrauner, Marcel Bermudez and from industry: Marcel Mülbaier and Clemens Dialer @grunenthalgroup.
0
0
2
Here, we discuss the potential for the development of analgesics, structure-activity relationships on NaV channels, biosynthetic hypotheses and chemical syntheses.
1
0
1
It is a great pleasure to share that our extensive review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family" has been accepted for publication at Angewandte Chemie: https://t.co/Au6xajx05a.
1
7
39
But that is not all! To showcase the potential of dfdc azobenzenes for the development of chemical tools, we synthesized dfdc-OptoBI-1 and demonstrated its biological activity as a red light-operated activator of TRPC6 channels in HEK293 cells.
0
0
0
The data was used to establish a computational approach that allows to compute realistic UV-vis spectra by combining TD-DFT excited-state calculations with MD simulations. Our combined study enables the in silico design of new highly red-shifted photoswitches.
2
0
2
We added 15 new visible light-operated photoswitches to the toolbox for the development of optical devices with relaxation rates across multiple orders of magnitudes and identified several examples with stronger bathochromic shifts than the dfdc azobenzene lead structure.
1
0
0
We have developed synthetic protocols for a variety of derivatives of the dfdc (di-ortho-fluoro-di-ortho-chloro) azobenzene scaffold and performed an in-depth study into their photophysical properties using NMR, UV-vis and X-ray analysis.
1
0
1
I am incredibly excited that our manuscript: "A Platform for the Development of Highly Red-Shifted Azobenzene-based Optical Tools" has been accepted for publication at Angewandte Chemie: https://t.co/T4NDkV2W9v🤩
5
21
141
We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team at the University of Vienna. For details, visit: https://t.co/53yARkZzkd. Reposts are very much appreciated!
18
121
284
📢 Only one more week left to apply!
We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univienna. For details, visit: https://t.co/32hVK11MXe. Reposts are very much appreciated!
1
5
23
We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univienna. For details, visit: https://t.co/32hVK11MXe. Reposts are very much appreciated!
3
97
241
Proud to share our work by a fantastic team, spear-headed by PhD student @Kainerox with major contributions by #xenopus expert @RosiFeistel. We developed an improved iAPEX-based #ProximityLabeling method for #massspec based subcellular #proteomics. https://t.co/0jDlrlkK7M
4
25
81
Very excited to see our work on photoswitchable menthol (AzoM) to control the cold receptor TRPM8 published! Our chemical probe allowed the analysis of current kinetics, and the roles of individual amino acids in channel gating, AzoM binding and modulation by PIP2.
Optical Control of TRPM8 Channels with Photoswitchable Menthol (Michael Mederos y Schnitzler and co-workers) @DavidBKonrad #openaccess 🔓
0
1
14
Big thanks to @ThornSesholdLab, @HellmichGroup and Sean M. McKenna for curating the starter packs!
0
0
0
I am amazed at how efficient the mass migration is going 🥳 Come find me: @dbkonrad.bsky.social. Here are community starter packs to follow: ChemBio: https://t.co/Ea19RTH9aZ MedChem: https://t.co/aYedf9K0l2 Lipids/MembraneProteins:
1
0
2
@ blue skies, there is https://t.co/zz7OjZ35rp a collection of 150 chemical biologist accounts to make it really easy to jump start your #ChemBio network. Why not at Twitter? :( no wonder people are leaving here.
1
5
14
Online now! Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt, et al at @scrippsresearch @broadinstitute @harvardmed
0
13
48
Soo much looking forward to this 🤩
Almost wrapping up the speaker introductions! @DavidBKonrad and Markus Furegati @Novartis_CH will demonstrate how technology is pushing the boundaries of photochemistry. Don't miss out! Join us in Amsterdam from Dec 2-4! Register here: https://t.co/p4Qj1l8gOm…
0
0
2
We are beyond excited to share our latest work on the role of PRDX6 in #ferroptosis out today in @MolecularCell and spearheaded by two exceptional postdocs in our lab, Junya and @eikan_em ! https://t.co/DJnxngaIUl
cell.com
Ito et al. highlight peroxiredoxin 6 (PRDX6) as a critical regulator of ferroptosis. As a selenium-acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein...
8
29
157