Cui Lab (Weiguo Cui)
@Cui_Lab
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Memory T Cell Biology | Viral Infection | Cancer Immunology | Autoimmunity
Chicago, IL
Joined March 2021
Join us on 11/9/23 at 3:30 pm as we host Dr. Alegre from @UChicago @UChi_Immunoeng who will give a talk "Vulnerabilities to Transplantation Tolerance" https://t.co/0r7AsiPV09
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Interested in a pathology residency at Northwestern Pathology? Join Chairman @DanielJBrat and Residency Program Leadership for a Q&A on 8/24/23 from 10-11am CST! Register here: https://t.co/E9q9qjtvdw
#PurplePath #PathMatch24 #PathTwitter
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Very excited to share our recent work highlighting the role of the PBAF complex in regulating CD8+ T cell exhaustion. This has been a great team effort from #JianShen and #RyanBrown at @Cui_Lab Also, see similar work @EJohnWherry
https://t.co/J6j1QfihP8
cell.com
During chronic viral infection, progenitor CD8+ T cells undergo bifurcated differentiation toward effector and exhausted lineages, but the chromatin structure changes orchestrating this transition...
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Headline should have read “Bishop to take charge after Gene deletion” @EugeneOltz
@ImmunologyAAI and @J_Immunol are very happy to welcome our next Editor-in-Chief, Dr. Gail Bishop @UIowaMicrobio @IowaMed
https://t.co/q3Ck0KUm1r
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So honored to have received the @DamonRunyon Dale F. Frey Breakthrough Scientist Award and to get to share what our lab does at the annual fundraiser! @UPMCHillmanCC @PittTweet @Pitt_PMI
Damon Runyon-Dale F. Frey Breakthrough Scientist @OveracreLab shares her groundbreaking work on how the gut microbiome influences anti-tumor immunity and patient response to immunotherapy treatment.
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Congratulations to Christine Nguyen on her doctoral degree hooding ceremony! It's a remarkable accomplishment. I am so proud of her! Wishing her continued success in her academic and professional journey.
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Huge congratulations to Chrissy for her successful dissertation defense! Well-done, Dr. Nguyen!!
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Had an amazing day at the Center for Human Immunobiology (@immunology_nu) at Northwestern. Great meeting everyone there and seen some old friends. And, amazing vision and leadership from @StephanieEisen Thanks for having me.
Reminder - join us tomorrow in SQ Auditorium! We are excited for Dr. John Wherry's seminar on Mechanisms of T Cell Exhaustion for Human Immune Health.
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So excited about our paper in @CellReports!! This was one of the most challenging, but exciting projects I’ve ever worked on. Thank you to all my coauthors and supporters!! @Cui_Lab @Razander @MoujtabaK @ashkayebrown @wlinsiying
Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection
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Congrats @PTopchyan and @Cui_Lab on your new paper in @CellReports! Incredibly cool use of @10xGenomics Visium spatial transcriptomics to study how loss of CD4 T cells impairs the antiviral response during chronic infection!
cell.com
To address why repopulated CD4 T cells after initial depletion fail to rescue the functional effector CD8 T cells during chronic LCMV infection, Topchyan et al. apply spatial transcriptomics and find...
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Super excited to share this study that shows T cell exhaustion ain’t exactly linear. Best part- this was a fun collaboration with Kaech lab alumns Weiguo Cui @Cui_Lab & Nik Joshi @Joshilabyale. Great work from our trainees @MoujtabaK @HKayChung1 @Razander
Study by @MoujtabaK, @Razander, @Tcellogic, @Cui_Lab & colleagues elucidates novel mechanisms underlying CD8+ T cell fate determination during persistent infection & suggests two potential pathways leading to exhaustion. https://t.co/ggeKbrYqb3
#InfectiousDisease #HostDefense
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How do #interferons switch to become suppressive and limit T cell responses to cancer? It’s IRF2! Potential for future #immunotherapy! Great study @sabslukhele and colleagues. @ImmunityCP
@UHN @pmcancercentre @uoftmedicine
https://t.co/iiAxNPjgKf
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When @NUFeinbergMed alumnus met Northwestern prof. outside of Chicago. I’m like an antibody captures its antigen (what a weird feeling) I miss NU 🥰. Really interesting talk by @Cui_Lab surprisingly his lab is also interested in BATF and expanding to IRF4 (I assume SE was formed
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Had a fantastic visit to Yale! Thanks @Joshilabyale for the invitation and for the great opportunity to share our research with @YaleIBIO. Enlightened by many extremely smart minds. Also, it’s very nice to stand side by side with Nik at our old bay!
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Thrilled to finally share our findings! This was a huge collaboration; science (and concomitant mentorship) is a team sport even in the era of single-cell sequencing. So thank you @Razander @PTopchyan @Cui_Lab @Tcellogic @Joshilabyale @tarakanova_vera and all other coauthors!
Using scRNA-seq and scTCR-seq, Kasmani @MoujtabaK, Zander @Razander @Cui_Lab, Kaech and colleagues identify multiple branching pathways regulating CD8 T cell differentiation during chronic viral infection. https://t.co/ggeKbrYqb3
#InfectiousDisease #HostDefense
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Using scRNA-seq and scTCR-seq, Kasmani @MoujtabaK, Zander @Razander @Cui_Lab, Kaech and colleagues identify multiple branching pathways regulating CD8 T cell differentiation during chronic viral infection. https://t.co/ggeKbrYqb3
#InfectiousDisease #HostDefense
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Check out publication by @Cui_Lab and colleagues in @eLife: Delineating the transcriptional landscape and clonal diversity of virus-specific CD4+ T cells during chronic viral infection
elifesciences.org
CD4+ T cells responding to chronic lymphocytic choriomeningitis virus infection display transcriptional heterogeneity that is marked by both lineage-specific gene expression profiles and core gene...
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Thank you to all the amazingly talented, creative and motivated postdocs I have or had the honor to work with!! Your grit, curiosity and discoveries are the engine of science. Be proud, know you are appreciated, and enjoy your accomplishments. #NPAW2022
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Xiaopeng Wu et al. @Cui_lab reported that BATF globally shapes the chromatin landscape of intestinal ILC3s, which in turn orchestrates microbiota and mucosal CD4+ T cell immunity. https://t.co/hEDEYp7YiG
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