Check out my and @ProfJudiAllen's commentry in @ImmunityCP on how IL-4 signalling in macrophages protects against aging. Great work from the Yifu Qiu lab. So many implications. @TCDTMI @LydiaBeckerIII

RT @PhilippWeiler7: I am really happy and excited to see CellRank 2 out in Nature Methods (! @naturemethods @Helmho….

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Still time to submit a CV for a PhD with me in @tcddublin @TrinityMed1. Investigating differentitation paths of macrophages in kidney autommunity. EU applicants only. DM or email a CV. Search research jobs in school of medicine at for deets.

Nice preprint @barton_lab. KLF2 in large (serous) cavity macrophage development. Much more complex role for Tfs than in 2014. Now we have a complex interplay of many TFs, Bhlhe40, Rxrs, Gata6. KLF2 acts early, before retinotic acid.

RT @tcddublin: Researchers from @TrinityMed1 have explored the use of extremely rare immune cells to predict how well treatments work for c….

@scienceirel @kiplet69 @THKC1 I got huge support from Trinity Translational Medicine Insitute @TCDTMI to devleop a single cell omics platform (formal launch soon). Thanks to Director Aideen long, Eamon Breen, Frank Mangan, Ross MacManus, Nicole Wood.

Personal thanks to @scienceirel for funding my salary. Mentor @kiplet69 from my future home in the Trinity Kidney Centre @THKC1 (exciting news to follow), for retraining me in translational human research and the statistics required to make it a successs.

See our study on Mast Cell progenitors, out in @AllergyEaaci. My 1st senior author work, along with Niall Conlon @TCDTMI @TrinityMed1. Collab effort @tcdflow @ClionaOfarrelly, many more! Katie Ridge @ridgek was the talanted driving force behind the study.

Hey anyone have R code to convert CITE-seq data in Seurat (or similar) into .FCS files for use in @FlowJoNow? flowcore @Bioconductor can write FCS files but I don't want to write the code myself, I'll mess it up!.

On twitter for the first time in 6 months: nearly get scammed on gig tickets and my feed is 80% culture war, 10% science, 10% NSFW, wtf? (still better craic than linkedin I suppose).

RT @RoserTP: Thrilled to see this work out! It’s been an absolute pleasure to lead this project at the @Hepworth_Lab! See below for a nice….

RT @immulology: I'm excited to finally share my FIRST first author paper out now in @eLife ! We found that C1q functions as a regulator of….

RT @THKC1: A couple of posts in the #biomarker space to help develop personalised algorithms for prediction of #autoimmune disease relapse,….

So cool, always felt the RNA velocity analysis was unstable when messing with hyperparameters, looks like a more stable way to infer cell development.

2nd author @JamesEP_ who is fast becoming the most capable scientist at @LydiaBeckerIII. @ProfJudiAllen All the team (@AChenery_ @jesuthas86 @Lili_Zhang_Dr @PH_Papotto Stella Pearson to name only few!) for making my time there so exciting and fun.

To point out 2 authors. @Labninja2 our resident parasitologist. The L. sigmodontis parasite is a precious resource that very few labs have the capacity to provide. We had Brian to make it happen all while keeping a smile on everyone's face.

Thanks to the staff at the core facilities in Manchester who made this work possible. @The_MRC @wellcometrust for (continued) funding. My wonderful new home @TCDTMI @THKC1 @scienceirel who provided the platform to get this over the line back in Ireland.

We recently found out from @GwenRandolph_ that humans have many more Converting Cavity macrophages than GATA6+ resident macrophages - making them more like BALB/c mice. I wonder what is going on in the cavities of those infected with mansonella spp of worms?.

Mapping the development of monocytes into tissue resident macrophages - we show that they change their function, radically, along that development path, increasing capacity to be M2 over M1 activated. This is the area I most excited to explore in the future.

An unanswered question is if strain differences in macrophages development is extrinsic or intrinsic to the macrophages (epigenome)?.