Kai-Hsiang Chuang
@Chuang_Lab
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MRI physicist, Functional brain imaging, Biomedical engineering, Neuro
Joined January 2023
Intra-cisternal Gd contrast MRI is a gold standard for imaging glymphatic function in vivo. But, a large Area-Under-the-Curve (AUC) is not necessary "high" glymphatic flow. It could be slow efflux, leading to more Gd retention. For detail:
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Does cholinergic neurodegeneration impact glymphatic system?.We lesion cholinergic neurons that project to the hippocampus. We find hippocampal, but not cortical, vascular-CSF concordance is impaired, suggesting a causal role. For detail:
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We uncover cholinergic deficits in aging affect CSF dynamics using simultaneous fMRI and cholinergic PET scans in healthy elderly. For details, see
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Our new findings highlight an important role of cholinergic deficits in glymphatic dysfunction in aging.
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Our 6-yr efforts is finally published on Nature Communications!. We discover a neural pathway that regulates the glymphatic system. Its deficit in aging and dementia may result in the pathology. This suggests new targets for diagnosis and treatment.
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How is the glymphatic system regulated? .Why it is impaired in aging and Alzheimer’s disease? .Now we have a new answer: the cholinergic neurons!.
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This blew me away.
11/ SORDINO for cross-brain coupling during social behavior 🐭🐭: We developed a dual-mouse hyperscanning platform, enabling simultaneous fMRI of two interacting mice. SORDINO reveals synchronized inter-brain activity in DMN & SN, uncovering neural dynamics of social interactions
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Revolutionary!.
1/ Six years in the making! Our preprint on SORDINO fMRI is out. We're sharing the raw data and sequence to facilitate brain-wide mapping in awake, behaving rodents. If this could be useful to your colleagues and friends, please help spread the word! .
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This is what’s bugging me about AI denoise. Vendors always show you how pretty the normal human image is improved. But the real issue is whether it will also clean up pathology??.
Are you using noise reduction software on your CT KUBs?. Beware! We had a near miss recently. Very modern software (this one is a deep-learning algorithm) can smooth out even 7mm calculi . Check your scanner as AI isn’t always that smart
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Insightful study for us working on small sample size:).
🚨 Brain Age vs Direct Models in Alzheimer’s disease (AD) 🚨 A thread 🧵. 1/ Brain age is a powerful indicator of general brain health, trained on massive datasets. But does this translate to better prediction for specific outcomes, like AD?. Preprint by @twktan :
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A neat design that addresses the awkward position of rodent body in MRI and results in greatly improved sensitivity of CBF imaging.
Very proud - @sara_pmonteiro (co-supervised by @patricia_mpfig) developed a new experimental setup for higher resolution (>x10 ) CBF mapping in rodents, with sequences by our collaborators Emmanuel Barbier and Lydiane Hirschler Setup designs are provided!.
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More rigorous testing like this is needed to design effective nuisance removal methods. Yet, the simulated movement didn’t include the effects of magnetic field change induced by real motion.….
Shin et al. assess residual motion artifacts in fMRI data using a simulated motion acquisition sequence with an ex vivo phantom to identify effective nuisance regressors: @afni_pt @mallarchkrvrty1 @fMRI_today @OHBM
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RT @Valerio_Zerbi: 🔔🔵After nearly 5 years from its conception with @BohacekLab, I'm proud to share that our paper on opto-fMRI of the Locus….
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RT @denislb: Just out from the press, my article for the 40 year anniversary of Diffusion MRI showing how the first years (1984-94) shaped….
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What regulates waste clearance of the brain?.Using human & animal imaging, we identified a neural pathway that modulates BOLD-CSF coupling and glymphatic flux. Its degeneration in aging and dementia could underlie glymphatic deficits.
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RT @Valerio_Zerbi: 💡1 PhD and 1 Postdoc position still open for joining my new lab @unige_en and help us re-defining the use of MRI for tr….
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We’re recruiting a PhD student to study how our brain clear the waste (glymphatic system) and how to enhance its function to facilitate health.
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RT @Gozzi_Ale: 📢 My lab has 3 fully-funded #PhD scholarships at @cimec_unitrento. The candidates will work in my lab @IITalk in #Rovereto….
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A beautiful study showing how neuronal circuits of DMN interact and got disrupt in disorder.
Happy to see this collaborative work out @NatureNeuro majestically led by @LabPapaleo and his superstar🌟team!.Take-home messages for brain imagers:.1⃣ Human👨default mode network (DMN) connectivity (PFC--> PCC) is associated with emotion recognition.1/2
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