Mangyu Choe
@ChoeMangyu
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Scientist working on mitochondria and redox biology
Dallas, TX
Joined June 2019
Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar! Huge congrats to my friend and colleague @CRI_UTSW @JaviGBermudez , who’s also joining the Pew family as a Pew-Stewart Scholar. CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨
Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — @JaviGBermudez & @HijaiShin — to advance cancer, biomedical research. Read more about their #relentlessdiscovery ⬇️ https://t.co/MAFSU4zUqs
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👏 👏 👏 👍 👍 👍
Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — @JaviGBermudez & @HijaiShin — to advance cancer, biomedical research. Read more about their #relentlessdiscovery ⬇️ https://t.co/MAFSU4zUqs
@pewtrusts
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Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — @JaviGBermudez & @HijaiShin — to advance cancer, biomedical research. Read more about their #relentlessdiscovery ⬇️ https://t.co/MAFSU4zUqs
@pewtrusts
cri.utsw.edu
Javier Garcia-Bermudez, Ph.D., Hijai Regina Shin, Ph.D., selected to advance cancer, biomedical research DALLAS – Aug. 12, 2025 – Two Children’s Medical Center Research Institute at UT Southwestern...
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Final version of our paper showing that a redundant function of several allosteric regulators of glycolytic enzymes HK and PFK is to inhibit the reaction of Harden and Young. Led by @ChoeMangyu in collaboration with Tal Einav and Rob Phillips. A 🧵... (1/)
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🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
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New preprint from our lab led by @ChoeMangyu where we develop a genetically encoded tool for manipulation of ΔΨm and use it to show that uncouplers have major side effects and ISR in response to ATP synthase dysfunction is driven by ΔΨm. A 🧵... 1/8
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I am excited to finally share one of my postdoctoral projects. @Denis_V_Titov @HijaiShin - Thank you again for all your support!!
Excited to share our lab's new paper led by @ChoeMangyu where we co-opt UCP as a genetically encoded tool for manipulation of mitochondrial membrane potential. We use this to demonstrate that high ΔΨm drives integrative stress response in response ATP synthase inhibition... 1/2
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New preprint from our lab led by @ChoeMangyu where we develop a genetically encoded tool for manipulation of ΔΨm and use it to show that uncouplers have major side effects and ISR in response to ATP synthase dysfunction is driven by ΔΨm. A 🧵... 1/8
biorxiv.org
Mitochondrial membrane potential (ΔΨm) is one of the key parameters controlling cellular bioenergetics. Investigation of the role of ΔΨm in live cells is complicated by a lack of tools for its direct...
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The Shin lab is open for business on the 12th floor @CRI_UTSW!! Come chat about science, life in Dallas or anything😎
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Amazing lab, friends and mentor @RobertoZoncu. I couldn’t have hoped for a better environment. Thank you everyone!! Time to begin another amazing journey in my new home @CRI_UTSW . The Shin lab opens in January 2024. Stay tuned 🎉🤩🎊
Z-lab get-together to bid farewell to Regina @HijaiShin, who will very soon open her own awesome lab at @CRI_UTSW. Our lab won’t be the same w/o you, but we can’t wait for all the great discoveries you will make!!
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Z-lab get-together to bid farewell to Regina @HijaiShin, who will very soon open her own awesome lab at @CRI_UTSW. Our lab won’t be the same w/o you, but we can’t wait for all the great discoveries you will make!!
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Excited to share updated preprint by @ChoeMangyu showing that, contrary to textbook view, the role of allosteric regulation of glycolysis is not to control rate but to maintain ATP levels by preventing a futile cycle between upper and lower glycolysis. 🧵 https://t.co/gofGtCvwu7
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Some update and GREAT NEWS I am happy to announce that I’ll be joining UTSW/CRI @CRI_UTSW as assistant professor in January 2024. The Shin lab will work at the intersection of lysosome signaling and lipid metabolism, particularly focusing on their implications in human diseases
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Thank you @UofUBiochem for having me! I look forward to my visit at the beautiful Salt Lake City 🥰
On Mon, Feb 27, Dr. Hijai Regina Shin @HijaiShin from @RobertoZoncu's lab @UCBerkeley will present on the "Lysosome at the center of sterol sensing and growth regulation." 4pm at HSEB 1750!
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2022 Deuel Conference in Monterey CA. In person conference in 2 years!! Thanks to the organizers for this awesome opportunity.
Regina @HijaiShin delivering an excellent presentation on her latest finding about cholesterol-dependent mTORC1 activation at the 2022 Deuel Conference on lipids!
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Whoa!!! Congrats @doudna_lab on the Nobel and the free parking spot!!! #GoBears 🐻🎉🍾🎊🥳
The moment you realize you finally get a parking spot @UCBerkeley. 🌟 Congratulations Professor Doudna! @NobelPrize #CRISPR #GoBears! https://t.co/6uz4viJStm
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Our review is finally out in @Dev_Cell !! It was fun writing it during the shelter-in-place. Highly recommended to everyone interested in #lysosome,#autophagy, #mTOR. Plus, I think it's very well written :-p Couldn't have done this without @RobertoZoncu
New Review online now at Dev Cell: The Lysosome at the Intersection of Cellular Growth and Destruction -
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Covalent targeting of the vacuolar H+ATPase provides a new strategy for mTORC1 inhibition and autophagy activation. Great collaboration with @DanNomura lab, just out in @nchembio. Congratulations to co-first authors Clive Chung and @HijaiShin: https://t.co/MAgSJQIHtS
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