Crys Conn
@CSConn_PhD
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Assistant Prof @PennMedicine #RNA translation in cancer bio. Advocate for Science, Research, Healthy living & Equality #STEM #FirstGen #Fluid They/them
Philadelphia, PA
Joined April 2011
RT @lianafaye: This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolu….
biorxiv.org
Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing...
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RT @FrydmanLab: New exciting work from Jae Ho Lee in our lab, in a fantastic collaboration with Alessandro Ori @AOri_lab and Alessandro Ce….
science.org
Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on...
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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RT @LilingWanLab: (1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic cond….
biorxiv.org
Aberrant chromatin-associated condensates have emerged as drivers of transcriptional dysregulation in cancer, yet the mechanisms regulating their formation and function remain poorly understood....
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RT @DrSTANtheMAN: Early methionine availability attenuates T cell exhaustion @NatImmunol
nature.com
Nature Immunology - The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents...
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RT @BenStanger01: 50% OFF From One Cell: A Journey into Life's Origins and the Future of Medicine - through Aug 11!
audiobooks.com
Each of us began life as a single cell. From this humble origin, we embarked on a risky journey fraught with opportunities for disaster. Yet, amazingly, we reached our destination intact, emerging as...
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RT @lab_gomes: Super excited to share our newest piece out today @NatureRevCancer linking age-induced metabolic reprogramming to cancer dev….
nature.com
Nature Reviews Cancer - In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of...
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RT @NobelPrize: Remembering the remarkable Marie Skłodowska Curie - awarded the 1903 physics prize and 1911 chemistry prize - who passed aw….
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RT @ShechnerLab: Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @C….
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RT @CedricBlanpain: I am delighted to share our new study uncovering the role of innate immunity in regulating cell plasticity and reprogra….
nature.com
Nature Cancer - Blanpain and colleagues delineate lineage reprogramming following PTEN deletion in different prostate cancer-originating cells, demonstrating that in basal cells the NF-κB...
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RT @LiuFange: WE ARE HIRING: Postdoc Positions! Join us at UPenn in vibrant Philly, cutting-edge science, great city, amazing team. Please….
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Fantastic lecture by, new to UPenn, faculty Dr. Booker. Welcome to Penn and thank you for openly hosting a wonderful lecture for all today!
✊🏽 Celebrate Black freedom, resilience & community!. 📅 June 18 – Seminar w/ Dr. Squire Booker.📅 June 21 – Freedom Day Celebration. Planned by our trainee leaders to honor Black history with reflection, joy & education. 🎟️ RSVP via flyer QR codes. All are welcome.
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RT @ShorterLab: Control of epithelial tissue organization by mRNA localization:
nature.com
Nature Communications - Subcellular mRNA localization is prevalent but with poorly understood physiological roles. Here, the authors show that Net1 mRNA targeting to the basement membrane controls...
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RT @Aiims1742: Second paper on HMGA2 mediated basal identity in #PancreaticCancer from Sita Kugel @fredhutch. This one is an elegant mechan….
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RT @TheModzLab: WE ARE HIRING (Postdoc Position)! Please share this with anyone who might be interested. Philly and UPENN are waiting for y….
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RT @genophoria: Really excited to see this published! From observations we made in our lab… to a blood test that works in real life scenari….
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Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab @smslmoon .#ribosomes #uORF #mRNATranslation #StressResponse .
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RT @MolecularCell: Quality over quantity: Small RNA pauses translation elongation to lift protein activity https://….
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RT @genophoria: Check out our latest preprint, led by @schen_sc, that brings together an amazing team of scientists from several labs to ta….
biorxiv.org
Transfer RNAs (tRNAs), once viewed as static adaptors in translation, are now recognized as dynamic regulators of gene expression. While recent studies have illuminated roles for tRNA stability, the...
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RT @CellChemBiol: Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunc….
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