Liu Lab (Dr. Kathy F. Liu)
@LiuFange
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Associate Professor of Biochemistry and Biophysics @ UPenn (RNA-processing and -modifying enzymes in sex-specific RNA biology)
Joined July 2019
Please see our review article in NSMB, “Mechanisms and genomic implications of BIR”. Adel Atari and @HaoyangJiang2 focus on mammalian BIR, its relationships to human disease, and genome engineering. Thanks to reviewers for helpful comments. https://t.co/RHa74TmS2F
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WE ARE HIRING: Postdoc Positions! Join us at UPenn in vibrant Philly, cutting-edge science, great city, amazing team. Please share and let's get in touch!
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We are looking for a postdoc candidate in RNA chemical biology, broadly defined. Interested applicants can email me at rkleiner@princeton.edu with their CV, research summary, and names of 3 references.
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Thank you, Damon Runyon, for your incredible support! Excited for the upcoming years with my team as we delve deeper into understanding sex differences in cancer! Congratulations to all the awardees!
We’re also thrilled to offer continued funding to this year’s Stage 2 Innovators @LucasFarnung, @raflynn5, and @LiuFange, who are expanding our knowledge of gene translocation, cell surface RNA, and Y chromosome proteins to make breakthroughs in cancer research!
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We made the cover of Genome Research! Check out our latest paper on DDX3X and DDX3Y - the first X-Y gene pair with cross regulatory capabilities ( https://t.co/37V63uyxJX).
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3. Clustering into nano-sized formations of over 50 molecules optimizes helicase activity for both proteins. 4. DDX3Y shows similarities to certain cancer-associated DDX3X variants, forming larger clusters linked to reduced helicase activity.
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key points of the work: 1. DDX3Y functions as a helicase at several times slower than DDX3X. 2. The RNA-release step is one of the major steps distinguishing DDX3X and DDX3Y.
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Huge congratulations to the leading authors Amber, Shweta, @rna_owens, and all co-authors. We are very grateful for the support from @AmericanCancer and @DamonRunyon
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The second Thanksgiving science dish we’re serving up is here, excited to share our new work on sex chromosome homologous proteins DDX3X and DDX3Y, titled “RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity” in Current Biology!
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Here's to science, collaboration, and pushing boundaries — Happy Thanksgiving!
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3. Wild-type DDX3Y enhances condensation viscosity and alters the proteome in DDX3Y-DDX3X mutant condensates, distinct from the effects seen in DDX3X-DDX3X mutant condensates.
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Key points of the discoveries: 1. DDX3X cancer variants uniquely impact enzymatic activity, cellular morphology, and function 2. Certain clinically severe DDX3X variants form hollow condensates within cells, likely resulting from disrupted RNA release.
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A huge high five 🖐️ to our rockstar leading author @rna_owensand, and all the amazing co-authors! We’re incredibly grateful to @DamonRunyon and @AmericanCancer for supporting this journey.
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In the spirit of Thanksgiving, we're serving up some science! Thrilled to share our new work on sex chromosome homologous proteins DDX3X and DDX3Y, — now published in Nature Communications!
nature.com
Nature Communications - Here the authors find that DDX3X mutants with catalytic impairments form hollow condensates in cells that have slower dynamics when co-condensed with DDX3Y than with WT...
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We are thrilled that Squire Booker will be joining the Depts of Chemistry and @BB_UPenn as a Penn-Integrates-Knowledge Professor in January 2025. Squire is a world-renowned enzymologist, @HHMINEWS Investigator, and dedicated mentor. Welcome! @PennSAS @BookerMan_PSU
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Thrilled to welcome Squire to our department! A true leader in the field and a guiding beacon for young scientists. We’re incredibly fortunate to have him on our team—excited for the journey ahead together!
We are thrilled that Squire Booker, Ph.D. will be joining the Departments of Chemistry and Biochemistry & Biophysics as a Penn-Integrates-Knowledge (PIK) Professor in January 2025. Squire is a world-renown enzymologist, an HHMI Investigator, and a dedicated mentor. Welcome!!
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Assistant and Associate Professor positions available at UPENN's Basser Center for BRCA . Great opportunity to be part of an amazing scientific environment. Assistant Level: https://t.co/U15zUBg2le Associate Level :
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Our paper on how X chromosome alterations drive sex differences in translocation renal cell carcinoma is now out in print @CellCellPress! Link to explainer thread if you missed it 👉:
The new issue is out 👉 https://t.co/uP2kI6DjtL Featuring how X chromosome genetics constrains somatic alterations and underlies cancer sex differences, the functional mapping of RAD51C variants in cancer and single-cell genomics identifying markers of neuronal vulnerability and
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