Chantal van Opbergen
@COpbergen
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Postdoc in cardiac electrophysiology - @AmsterdamUMC - ACS Talent Fellow - studying cardiac arrhythmias 💔
Amsterdam, The Netherlands
Joined March 2020
Feeling very honored for being awarded the #ARVC Basic Science Research Prize in Zurich today! Special thanks to my great mentor @MarioDelmar3, @AliciaLundby and all co-authors on this study. Fantastic meeting organized by the ARVC international symposium committee! @NYULHCVRC
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Exciting symposium on arrhythmogenic cardiomyopathy (#ACM #ARVC). Working towards gene-specific criteria with many of my great colleagues on day 1: @JuliaCTourigny @HughCalkinsMD @ASaguner @Cristinabasso64 @MarioDelmar3 @COpbergen @KristinaHaugaa @jpkaski
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Very proud and honored for this amazing recognition of our work on #genetherapy for #PKP2 #ARVC !! 🫀🧬 Special thanks to @SADSFoundation for this nomination and the entire team for this phenomenal teamwork! @marina_cerrone @MarioDelmar3 @NYULHCVRC @nyugrossman
Congrats to @COpbergen of @nyulangone for winning our SADS Foundation Courts K Cleveland, Jr. YIA in Basic Science for her work on #PKP2 #ARVC gene therapy! Mentors: @MarioDelmar3, @marina_cerrone. @PACESep @JeffKimMD
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Exciting to be part of the Moderated Poster session at #FCVB2024 today, to tell everything about pro-arrhythmic mechanisms in the #PKP2 deficient atrial myocardium! 🫀#ARVC #AF #RYR2 Stay tuned! @MarioDelmar3 @marina_cerrone @AliciaLundby @NYULHCVRC
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From @COpbergen @MarioDelmar3 @marina_cerrone + team: AAV-Mediated Delivery of PKP2a Arrests Progression of ARVC in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans https://t.co/drAkL3IjPY
@AHAScience #AHAjournals #CardioTwitter #Genetics 📽️@hj_tadros
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Very excited to see our latest paper on #genetherapy for #PKP2 #ARVC published in @Circ_Gen! 🫀🧬 Great collaboration with @RocketPharma! @marina_cerrone @NYULHCVRC @nyugrossman
https://t.co/ohA3ecUSup
ahajournals.org
BACKGROUND: Pathogenic variants in PKP2 (plakophilin-2) cause arrhythmogenic right ventricular cardiomyopathy, a disease characterized by life-threatening arrhythmias and progressive cardiomyopathy...
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End of an era; Yesterday was my last day at @NYULHCVRC… The last 4 years were absolutely amazing and I’m so grateful for all the support and opportunities and I’ve gotten from @MarioDelmar3 , @marina_cerrone and the rest of the team! Will miss NYC a lot! Next stop -> Amsterdam🇳🇱
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Our preclinical study in collab with @RocketPharma on #genetherapy for #PKP2 #ARVC out now in preprint! The @US_FDA IND application based on this study (+ extensive toxicology studies) recently received clearance to start Phase I clinical trials. 🧬🫀@marina_cerrone @MarioDelmar3
AAV-mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans https://t.co/rrHdbf2N0D
#bioRxiv
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Congratulations to @COpbergen ,one of our oral presentation finalists. Amazing talk on gene therapy of arrhythmogenic cardiomyopathy!
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Exciting times ahead for the #ARVC field! Great presentation by RocketPharma in Late-Breaking Oral Session @ASGCT about our preclinical studies on gene therapy for #PKP2ARVC. Stay tuned/Tune in on Sunday for the talk of @MarioDelmar3 at #HRS2023 for more details.. @marina_cerrone
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Always wanted to learn more about the intercalated disc? 🫀Our very extensive review on the topic now online in preprint @physiolrev! @MarioDelmar3 @MortenSchak @NYULHCVRC @nyugrossman
https://t.co/aE3L5a5C5R
journals.physiology.org
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via mechanical and electrical junctions. Although described in some detail by light microscopy in the 19th...
The intercalated disc: a unique organelle for electromechanical synchrony in #cardiomyocytes (@MortenSchak et al. @nyugrossman @UCPH_Research) - new in @physiolrev
https://t.co/DU35yEn0ax
#arrhythmia #articlesinpress
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Congratulations to @COpbergen on winning the Arrhythmogenic Cardiomyopathy Basic Science Research Prize, at the International Symposium on Arrhythmogenic Cardiomyopathies in Zurich! @MarioDelmar3 @marina_cerrone @alicialundby
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#ICYMI: Nuclear envelope integrity and DNA damage in ARVC @MarioDelmar3 @AliciaLundby @MartaPrezHernn2 @COpbergen @NYULHCVRC #AHAJournals
#OriginalResearch Mutations of PKP2 gene leads to the development of #ARVC via activation of the DNA damage response by disrupting the integrity of the nuclear envelope @psatolab @ulvedreng #AHAJournals
https://t.co/DqryFwCvlC
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Out now from the @MarioDelmar3 lab. "Loss of nuclear envelope integrity and increased oxidant production cause DNA Damage in adult hearts deficient in PKP2: A molecular substrate of ARVC." https://t.co/16dm7l9rJI
@MartaPrezHernn2 @COpbergen @AliciaLundby
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Our latest paper out today @CircAHA! New data on loss of nuclear envelope integrity, oxidative stress & subsequent DNA damage as key substrates in the molecular pathology of #ARVC. Great collaborative effort! @MarioDelmar3 @AliciaLundby @MartaPrezHernn2
https://t.co/lB1ZIehB66
ahajournals.org
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by high propensity to life-threatening arrhythmias and progressive loss of heart muscle. More than 40% of reported...
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Proud of this collaborative work! It suggest membrane-permeable β-blockers may be more efficient for patients with arrhythmogenic right ventricular cardiomyopathy and highlight the potential for ryanodine receptor 2 channel blockers as new treatment.
ahajournals.org
Background: Exercise training, and catecholaminergic stimulation, increase the incidence of arrhythmic events in patients affected with arrhythmogenic right ventricular cardiomyopathy correlated with...
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#OriginalResearch: Exercise causes arrhythmogenic remodeling of intracellular calcium dynamics in Plakophilin-2 deficient hearts @COpbergen @MarioDelmar3 @AliciaLundby @NYUCVCR #AHAJournals
https://t.co/KKjrS6pTIN
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So great being in the #HRS2022 #YIA competition yesterday morning!Although no win, it was an outstanding session and an honor to present and discuss our latest study on exercise-related cardiac calcium handling dysregulation in PKP2-deficient hearts!🫀 @NYUCVRC @MarioDelmar3
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Got the honor yesterday to accept on behalf of Marta, as co-first author, the YIA for our latest exciting study on DNA damage in ARVC!🫀@MarioDelmar3 Special thanks to the @SADSFoundation!
Winner of @SADSFoundation young investigator award for basic science to Marta Perez-Hernandez for work related to PKP2 and ARVC. Mentored by Dr. Mario Delmar.
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