“from one stage to the next a greater amount of proenzyme is activated, and it may be suggested that the need to link the minute physical stimulus of surface contact with the final enzymatic explosion has resulted in the evolution of a biochemical amplifier” -RG Macfarlane, 1964

RT @AegeanConf: Congratulations to all the trainee awardees! Great Work! Great Science! 17th Int’l Conference on #Complement Therapeutics.….

RT @AegeanConf: Program Available: 17th Int'l Conference on #ComplementTherapeutics from May 10-15, #Sissi #Crete #Greece ..

Zymogen activation is a ubiquitous strategy for regulating enzyme activity. In our @jbiolchem paper led by @HuiquanDuan, we show that blocking this fundamental process is used to inhibit the first proteolytic event of the classical #complement pathway 👇.

Congratulations to @HuiquanDuan for a successful defense of his PhD dissertation research on mechanisms of #complement inhibition! @KStateBMB

RT @brainaddiction: It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study pu….

RT @TanentzapfLab: Yesterday a Nobel prize was given for alpha fold. Alpha fold could not exist without the Protein Data Bank (PDB), a publ….

New work from our lab published in @jbiolchem!.👇.S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases - Journal of Biological Chemistry . Kudos to @Nitin_B_Mishra , @carsongido, and Tim Herdendorf for leading this effort! @KStateBMB.

First description of the self-amplifying nature of the #complement alternative pathway. Muller-Eberhard & Gotze, J. Exp. Med. 1972

Congratulations to @Nitin_B_Mishra for a successful defense of his PhD dissertation research on #Staph protease inhibitors. @KStateBMB

We participated in @AtomwiseInc #AIMS study published in @SciReports highlighting #AtomNet as a viable alternative to high-throughput screening! Read about the largest and most comprehensive virtual HTS campaign to date: #drugdiscovery #AI #pharma #biotech.

RT @J_Immunol: Former #JI_Editor @BvgLab @KStateBMB: 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide as a new class of small-molecule….

RT @roumenina: The first Legacy award for Complement Research was awarded today to Piet Gros by the @ComplementSoc International Complement….

Our latest paper reporting identification of a small-molecule inhibitor of #complement protease C1s and the classical pathway is out in the newest issue of @J_Immunol. Special thanks to the students and postdocs who contributed to this team-driven effort! .

RT @accardilab: Finally, a note on peer review that is currently so criticized. This work shows why peer review works! The experiments sugg….

RT @neurocomplement: 1/3 Excited to share our latest research by the talented Dr Xaria Li on cell-intrinsic C5a in pathogen sensing and fu….

RT @DavidRosowsky: This is going to be game-changing. We have launched a multidisciplinary hiring initiative at @KState to recruit 12 new f….

RT @CorneliusGati: Thrilled to present our manuscript out today in @CellCellPress. A tour-de-force on anaphylatoxin complement receptors -….

RT @dmastellos: How can we condense the expanding universe of #complementbiology into the confines of a few pages? Here's our humble attemp….

RT @AegeanConf: SAVE THE DATE: June 11-16, 2024. 16th Int'l Conference on #Complement #Therapeutics. Loutraki, Ancient Corinth, Greece http….