1. Excited to see our latest work in @natureComms.- “Fibre-specific mitochondrial protein abundance is linked to resting and post-training mitochondrial content in the muscle of men” . Led by @LizReisman, @javi_iup & @bluebirdi with @stroudlab. Thread 🧵👇🏽

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman Updated link to our ShinyApp ( that lets users explore specific genes and investigate skeletal muscle adaptation to exercise by examining gene clusters, sex differences, and varying fitness levels.

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman To improve access to this dataset, we have developed a ShinyApp ( that lets users explore specific genes and investigate skeletal muscle adaptation to exercise by examining gene clusters, sex differences, and varying fitness levels. 🧵 9/9.

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman Sex differences were minimal, with only 4 genes showing sex-specific differential expression post-exercise! For sex-specific enriched pathways, small differences in the cell type proportions between biopsies from men & women at specific time points likely played a role. 🧵 8/9

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman Our findings further question the longstanding dogma that proposes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins they encode (. 🧵 7/9

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman Despite previous research showing most mitochondrial proteins increase following training, nearly half of all mitochondrial genes, including those involved in oxidative phosphorylation, were characterised only by downregulation, particularly at 24 & 48 h post-exercise. 🧵 6/9

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman Consistent with a dampening of the transcriptomic response to exercise with a higher fitness, the differential expression of many genes, including those that encode mitochondrial and ribosomal proteins, correlated to VO2max (particularly at 24 & 48 h post-exercise). 🧵 5/9

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman Despite a common focus on the first 3 h post-exercise, thousands of genes were not DE until 24 and 48 h post-exercise and 25% of all differentially expressed genes were either upregulated or downregulated relative to baseline depending on the time point investigated. 🧵 4/9

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman In response to exercise, 16,625 genes were differentially expressed (DE) versus baseline, incl >7,000 genes not previously identified. This larger number of DE genes is primarily attributable to the greater sampling of time points, rather than the increased sample size. 🧵 3/9

@DaleFTaylor @LizReisman @bluebirdi @Romain_Barres @NolanJHoffman To investigate exercise-induced transcriptomic changes, 20 young men & 20 women completed a single high-intensity interval exercise session. Muscle biopsies were taken prior to, in the middle of, immediately post, and 3, 6, 9, 12, 24, & 48 h post-ex (9 biopsies in total!). 🧵 2/9

Excited to share our latest pre-print: .“Exercise induces time-dependent but not sex-specific transcriptomic changes in healthy human skeletal muscle”.Led by @DaleFTaylor with @LizReisman, @bluebirdi, @Romain_Barres, @NolanJHoffman & @JohnAHawley. 🧵 1/9

It's been a great experience establishing the Australia China Exchange tennis program in Jingshan, China.

It's been a really positive response so far to the NEW nature portfolio journal - Exercise Medicine and Health: which I've been appointed Editor-in-Chief. Please contact me about potential submissions or if interested in serving on the editorial board.

I like how this review by Simeon P. Cairns highlights that even the experts have disagreed on the effects of 'lactic acidosis' on fatigue & performance.

Latest from our group .highlighting how inhibitor contamination may affect the measurement of mitochondrial respiratory function when experiments are conducted in close succession.

Great to see the latest work by @alana_leabeater.now published: .The Acute Effects of Compression Garments on Muscle Protein Synthesis Markers, Blood Flow, Performance, and Perceived Recovery after Resistance Exercise

RT @MCRumpf: #footballresearch 28-2025 @Peter_Edholm @BlueSpotScience @IrineuLoturco @StefanAltmann3 @JimiVaughan @….

🧑🔬 NEW PhD scholarship available in my lab to investigate: . "Mitochondrial Adaptations to Exercise" 🚴.🗓️ Applications close: 14 September 2025 ; .✅ Eligibility: Open to Australian & International students.More info here:

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse .Another nice study from Evgeniia Motanova's PhD at Padova.

New study shows a limited influence of the menstrual cycle on mitochondrial characteristics:

Excited Australian Prime Minister, Anthony Albanese @AlboMP, noted our Australia-China Exchange Tennis Program while in Chengdu. This partnership b/w @victoriauninews & @TennisAustralia is supported by the National Foundation for Australia-China Relations (NFACR) 澳中基金会.