@GrilloAnthonyS @mkaeberlein Happy reading and let us know what you think. 7/7.

This work stems from @GrilloAnthonyS’s idea to compile over a decade worth of data in these mice. We are grateful for the help of countless undergraduate students who gathered all the data, and for @mkaeberlein who funded the majority of the studies these data are taken from. 6/n.

Thus, these mice can be used to test longevity interventions in a mammal in a short period of time. Also, this model demonstrates that geroscience can be successfully applied to non-age-related pathologies and bring new perspectives in our understanding of chronic disease. 5/n.

Other longevity interventions, such as low O2, NMN, and AKG are also effective, which raises the question of why treatments with different targets are successful in this model. We argue that aging and mitochondrial disease have shared underpinnings in the “Hallmarks of Aging” 4/n.

Ndufs4-/- mice live on average for about 2 months and have characteristic brain pathology and metabolic abnormalities. Remarkably, longevity interventions such as rapamycin, acarbose, and 17-alpha estradiol increase survival in this mouse model. 3/n.

Ndufs4-/- mice lack a key component of Complex I of the Electron Transport Chain and are thus incapable of mitochondrial respiration. They model a pediatric mitochondrial disease called Leigh Syndrome, a neurometabolic disorder that is currently incurable and poorly managed. 2/n.

Excited to share our latest publication in @GeroScienceAGE: "Ndufs4−/− mice: a testing ground for longevity interventions". In this paper, @GrilloAnthonyS and I introduce a transgenic mouse model exquisitely sensitive to longevity interventions. 🧵 1/n.

Congratulations to Rhea Misra for her poster presentation at the Mary Gates Undergraduate Research Symposium!

See their work on @eLife at:

With the holidays I missed the boat on sharing this little eLife Magazine piece I wrote last month. A small commentary on a very nice paper by Dylan Sarver and Will Wong at Johns Hopkins.

Also, follow the link for the cutest Ella interview ever.

I don't usually post about private stuff on Twitter/X but I feel this is important.@SeaPubSchools is planning on closing my children's elementary school upon budgetary concerns. The aftermath for my son and other children on the spectrum could be dramatic.

Very grateful to @NatMetabolism for the opportunity to share my views on this exciting paper.

Very excited to see this work on mitochondrial transfers by @BrestoffLab et al. come out: The implications for mitochondrial disorders and potentially aging are significant. Read my commentary here:

RT @bioagelabs: Upcoming webinar! On 6/18, BioAge CEO @kpfortney will moderate am @AFARorg webinar w/ @biogerontology of @InSilicoMeds, @mi….

Thank you so much @MariyaSweetwyne. I had an inspiration and I had to follow it. It seemed to have paid off.

Come see my poster tonight at #AGE2024. Could the Ndufs4 mice restore balance in the Biology of Aging?

Come hang out with yours truly and a number of far more deserving scientists (@BBParis1984, @CristalM_Hill, @OcanasSR, and @MattYousefzadeh for example) this summer in Bregenz. Great science in a great atmosphere, and very affordable for trainees!

Thank you @NIH_NINDS! Excited to dissect metabolism in mitochondrial disease and treatment thereof.

The quirks of NIH funding should not hinder the awesome science of the Dog Aging Project. Please help if you can!.