Monika Bambouskova
@BambouskovaLab
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Assistant Professor of Medicine @WUSTLmed @WashUMedEndo, alumni @imgprague. Lab focused on #immunometabolism, #signaling, inflammatory disorders.
Joined May 2020
Big congrats to @MargueriteMrad for winning the Outstanding Poster Award in basic science at Diabetes Day Symposium at @WashUMedEndo for presenting her work on immune-progenitor crosstalk in adipose tissue!
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I'm happy to present our new web-tool CORESH https://t.co/r1bswFuZXo for searching public gene expression datasets using gene signature as a query, developed by @vd_sukhov, which was just published in @NAR_open
https://t.co/PdDMgQz56a 1/n
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latest from our lab: ITACONATE MECHANISM SOLVED!! Tom Paulenda @tompaulenda solved molecular mechanism of immunoregulatory action of itaconate in macrophages: https://t.co/IymcPTZ7gy Previously, our lab has discovered two major immunoregulatory phenotypes of itaconate in
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Honored and excited to receive the 2025-2026 CTRFP Award! 🎉 Grateful for the support as we continue exploring links between metabolism and autoimmunity.
Read the ICTS Digest! Get to know the 2025-2026 CTRFP Awardees, register for the 7th ICTS Symposium, read articles in Missouri Medicine online journal & more! @WashUMedicine @WashUDeptMed @WashUSurgery @MIRimaging @MizzouNursing @SLU_Official Read more> https://t.co/gOmIEgRo2x
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Please check out this new work on the role of tetraspanin CD53 in lung inflammation! Big congrats to @ivana_hal and the team!!
If you have a sec, check out our new paper by @Amy_Hsu_ with @HibbsLab (@MonashImmunol) and @ivana_hal (@imgprague) showing that CD53 drives cellular infiltration and inflammation in allergic airway asthma-like disease in @AllergyEaaci (it's a quick read).
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Collaborative work of @slavicaPD, @Hashemyaser4, Jovanovic Lab and @DjuranovicLab - a new method to isolate ribosomes and translational material in minutes. We show multiple usage of our RAPPL method in biochemical and structural assays with ribosomes. Please be free to contact
biorxiv.org
Short abstract Ribosomes are essential RNA-protein complexes involved in protein synthesis and quality control. Traditional methods for ribosome isolation are labor intensive, expensive, and require...
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Preprint from my lab. Congrats @inhwajang_ Ina shows that Gdf3-SMAD pathway regulates macrophage inflammatory phenotype in old mice.
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging https://t.co/12n8KT6nrW
#biorxiv_immuno
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Thrilled and grateful to receive this year's Discovery Grant from @NPF! 🎉 Excited to explore how dysregulated metabolism contributes to psoriasis pathology. Looking forward to the discoveries ahead!
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Very excited to share our latest paper out today @NatMetabolism showing that #mitochondria transfer and transplantation may reduce the morbidity and mortality of #LeighSyndrome, a fatal mitochondrial disease with no effective therapies.
nature.com
Nature Metabolism - Administration of exogenous mitochondria from mice or humans, or stimulation of mitochondria transfer from haematopoietic cells through bone marrow transplant from wild-type...
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Excited to share our new preprint! A pilot study aiming to address underlying metabolic defect in hyper-IgD syndrome caused by mevalonate kinase deficiency. Amazing collaboration with @annasediva and @immuno_prague @WashUEndo @WUSTLmed. Check it out!👇
medrxiv.org
Mevalonate kinase (MVK) deficiency, a rare autosomal recessive disease, significantly impacts metabolism and immunity, leading to mevalonic aciduria in severe cases and hyper-IgD syndrome (HIDS) in...
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Very happy to share this new story from @LodhiLab. Congratulations to the whole team!
Please check out our new paper led by postdoc @lu_dongliang. We report that liver-specific KO of ACOX1 increases circulating levels of #omega3 VLCFA THA (C24:6) and HHA (C26:6) that promote adipose browning and decrease inflammation by activating GPR120. https://t.co/ofeIbKKXAc
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Fantastic tool that has always been super helpful – try it if you haven't yet! 😊 Congrats to @assaron and the team!
I'm happy to share that out paper on Phantasus, a web-application for visual and interactive gene expression analysis, got out in @eLife
https://t.co/fd99RQ2nIv Here, I'm using it to analyze a random GEO dataset, including basic QC to filter outliers, in under 100 seconds! 1/n
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Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis: Cell Reports https://t.co/Ol6WYY0DbL Congrats to first author Anna! Really excited to see this out! @shen_anna_gins
cell.com
Carey et al. demonstrate that inflammation is increased but lipolysis is reduced following sepsis or endotoxemia in old mice. They identify an accumulation of inflammatory B1 B cells and B2 B cells...
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30+ years after caspases were found to be interleukin-1 converting enzymes (ICE), the first caspase-cytokine structure is revealed. We identify caspase-4 as a specific pro-IL-18 converting enzyme and describe the CryoEM structure of this enzyme-substrate interaction.
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It was such a pleasure to visit @SLUbiochem and talk about our work! Had great and inspiring discussions with faculty and students. So much cool stuff going on there! Many thanks to @gonzalo_lab for hosting me!
Join us on Monday, October 2, at 3 pm, for a seminar by Monika Bambouskova, Ph.D., hosted by the @gonzalo_lab! @SLUbiochem @slusom
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@VAIMetabolism is recruiting for faculty to join the @VAInstitute Metabolism Department at all ranks. Join a growing and dynamic group using cutting edge technology to study the metabolic underpinnings of chronic disease.
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Endocrine-metabolic research at #WashUMed can be traced to the Nobel Prize-winning work of Drs. Carl and Gerty Cori. Among their trainees were Drs. William H. Daughaday and David M. Kipnis, who molded and led our division during the 1950s-1970s. Read more: https://t.co/7ehUYrsnFR
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Btw, I'm still open for job options. Especially I'd be interested to learn about industry opportunities in Europe. I'm the author of FGSEA package and other tools for analysis of omics data, but open to switching the area. Here is my CV: https://t.co/dLnmcjCpmk pls RT
drive.google.com
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We have a Postdoc position available to study lipid metabolism pathways and their relationship to metabolic diseases, including diabetes and obesity. Please visit https://t.co/xseVSeNTVZ for more info and contact me by email w/ your inquiries and CV. Please RT!
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