Cyclohexadiene derivatives deliver hydrogen atom equivalents through a tunneling mechanism.

Nature Chemistry - While saturated N-heterocycles are widespread motifs in drug discovery, the seven-membered ring azepane is highly underrepresented. Now nitroarenes have been validated as...

Nature - Selective borylation of azines—nitrogen-containing aromatic heterocycles used in the synthesis of many pharmaceuticals—is made possible by forming a radical from an aminoborane...

Nature Chemistry - The synthesis of aryl amines is traditionally achieved through aromatic nitration or transition metal-catalysed cross coupling. Now, photocatalysis provides a route for the...

We report here a mechanistically distinct approach to achieve Suzuki–Miyaura-type cross-couplings between alkyl iodides and aryl organoborons. This process requires a copper catalyst but, in contrast...

Here, we report a toolbox strategy to cross-couple unactivated secondary alkyl iodides with various N-, O-, and C-based nucleophiles. This strategy harnesses the ability of photoredox-generated...

The halogen-atom transfer (XAT) is one of the most important and applied processes for the generation of carbon radicals in synthetic chemistry. In this review, we summarize and highlight the most...

We report here a mechanistically distinct tactic to carry E2-type eliminations on alkyl halides. This strategy exploits the interplay of α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with...

Synergistic photocatalytic H-atom transfer and cobalt dual catalysis enables the desaturative synthesis of phenols from cyclohexanone derivatives by formal removal of four H-atoms.

Bicyclic amines are important motifs for the preparation of bioactive materials. These species have well-defined exit vectors that enable accurate disposition of substituents toward specific areas of...

PhD Project - Photoredox catalysis and asymmetric synthesis at The University of Manchester, listed on FindAPhD.com

A divergent strategy for the remote arylation, vinylation and alkylation of nitriles is described. These processes proceed through the photoredox generation of a cyclic iminyl radical and its...

Nature Catalysis - The SN2 reaction is essential in organic chemistry, but its substrate scope is limited. Now, a strategy based on halogen-atom transfer using α-aminoalkyl radicals and copper...

Nature Chemistry - The direct formation of C–N bonds onto arenes provides a simple route to synthesize a variety of important products. Now, formation of a highly polarized, aminium radical...

Daniele Leonori reports on a practical photoredox method to synthesize arylhydroxylamines.

Ortho-phenylenediamines are high-value molecules generally prepared using multistep synthetic sequences. Here, we demonstrate that they can be assembled in one chemical step from nitroarenes upon...

Highly electrophilic aminium radicals react with unfunctionalized aromatics to produce arylamines