
Alvin Chandra
@AlvinChandraMD
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Joined March 2019
Why has the United States handled this pandemic so badly? The Editors note that although we came into this crisis with enormous advantages, our current political leaders have demonstrated that they are dangerously incompetent.
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Proud to share our subanalysis from TOPCAT study regarding depression in patients with HFpEF #JACCHF #HFpEF #depression. https://t.co/px4eMFJhe1
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Fantastic work by @singh_kavisha which showcased the role of simulation in assessment of cardiology fellow performance in TTE scanning that's especially relevant in the COVID-19 era. @UTSWCardfellow
https://t.co/RwR5syzKAp
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The cholesterol story is never simple. Our work on multi ethnic cohorts from the US/Europe to see how HDL particles a/w vascular events and how that compares to HDL-C with @dranandrohatgi @AlvinChandraMD @DrPJoshi @dramitkhera @utswheart & others.
ahajournals.org
Background: High-density lipoprotein (HDL) cholesterol concentration (HDL-C) is an established atheroprotective marker, in particular for coronary artery disease; however, HDL particle concentration...
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So proud to share this @JAMACardio article written by my friend and colleague Dr. Riccardo Inciardi who's at the front line fighting #COVID19 in Italy. Also featured @nytimes. Thank you for sharing your valuable experience! https://t.co/brqIdHhD4W
https://t.co/KmEuaNHErw
nytimes.com
Cardiologists are seeing infected patients whose worst symptoms are not respiratory, but cardiac.
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Striking data in @ESC_Journals #EJHF by @PeterMoliner: How do pts with HFrEF die? The answer appears to be changing if asked in 2001 vs 2018. Reflects treatment successes & new challenges! Our accompanying editorial @RBPatelMD #AnjuNohria @JavedButler1
https://t.co/DFBGbBNLIE
Modes of death in #heartfailure is not what it used to be: less #heartfailure, more cancer deaths https://t.co/Y3WV3rdLoC
@MarcoMetra #HFA_ESC @HFA_President @Cardioonc @PeterMoliner #cardiotwitter
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📍Health-Related Quality of Life in HFpEF: PARAGON-HF Trial (compared with PARADIGM trial) 📌 HRQL was largely worse in women and was similar in HFpEF and HFrEF @JACCJournals @secardiologia @SACardiologia
https://t.co/ED3HzBrnFf
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Congrats @mvaduganathan @Hirji1987 for leading this study and thanks to all the coauthors for their help and contribution @AqamarMD @bajaj_nav @AnkurGuptaMD @CardioOncology @JavedButler1 @AlvinChandraMD Bonnie Ky, Mark Haykowsky, @vgzmd, anju nohria @UTSWNews @UTSWCardfellow
Efficacy of Neurohormonal Therapies to Prevent Cardiotoxicity in Pts w/ Cancer Featured in Inaugural Issue @JACCJournals
#JACCCardioOnc w/@Hirji1987 @ambarish4786 Meta-analysis (n=17): ~4% attenuation of LVEF decline, unmet need for large powered RCTs https://t.co/TCC4NnxQli
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Long-awaited #PROVEHF did not disappoint 🙌🏻: -Rapid (<2w) and large reduction in NT-proBNP (at lowest #entresto dose) -Sign reverse remodelling (LVEF +9% and LVMi -16 g/m2) -Consistent in RASi-naive; low NP and non-target dose CONGRATULATIONS @JJheart_doc @scottdsolomon
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Potential intriguing implications from the "neutral" #PARAGON_HF trial. Patients with lower LVEF may have benefits similar to #PARADIGM_HF #ESCCongress
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#PARAGONHF p=0.058 for primary endpoint: HR 0.87 (0.75-1.01) 👁Super interesting sex differences: HR 0.73 (0.59-0.90) in 👩🏻🦳 and 1.03 (0.85-1.25) in👨🏻🦳 👁Signal of better treatment effect with lower EF Let the debate begin! https://t.co/quU5zviG0q
@Novartis @scottdsolomon
nejm.org
The angiotensin receptor–neprilysin inhibitor sacubitril–valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure a...
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A paper we published a year ago closely related to our recent JACC HF #QOL in #HFpEF paper. @scottdsolomon
In this post hoc secondary analysis of the PARADIGM-HF trial, sacubitril/valsartan improved limitations in physical + social activities that are common in patients with heart failure, including sexual activities #Entresto #NeprilysinInhibitor #HeartFailure
https://t.co/KJ54IDKJe5
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It's like I'm rounding again with @MarkDrazner in the halls of old St. Paul Hospital. Thank you. @UTSWCardfellow
MY APPROACH to the Clinical Evaluation of Patients With Heart Failure https://t.co/lXAnWtvsGz via @practiceupdate. Hope you find this useful! @UTSWNews @utswheart @MKIttlesonMD @JTThibs @JLGrodin @HFSA @DrMarthaGulati @dramitkhera @UTSWInternalMed @UTSWCardfellow
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Thanks @mvaduganathan for sharing this! Proud to see our work with @scottdsolomon published
Largest assessment of #QOL across EF spectrum now pub @JACCJournals #JACCHF by @AlvinChandraMD & @scottdsolomon Pooled data @PARAGONHF & #PARADIGMHF (n=11,622) QOL worse in HFpEF compared w/ HFrEF, related to gender imbalance, ⬆️ signs/sx, & obesity https://t.co/PBWm3X0Zjs
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Happy to share our findings published at #JACC from the #DallasHeartStudy regarding the association of temporal changes in body fat distribution and #hypertension
New #JACC paper examines the association of temporal changes in body fat distribution with #hypertension in a multi-ethnic cohort. https://t.co/PbFDAGN6dm
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