4/ 💡 Clinical Implications In HT pts: Alirocumab = safe & powerful LDL-C lowering  Short-term plaque impact unclear  Possible reasons: low baseline LDL, inflammation-driven CAV, potent statins used Longer follow-up may be required #SoMeEditor @CircAHA

2/ 📊 Trial Design 114 HT recipients: 57 alirocumab vs 57 placebo All on rosuvastatin  Invasive coronary assessment at baseline & 1 yr: • angiography, NIRS-IVUS  • FFR, CFR, IMR  Primary endpoint: change in plaque volume #SoMeEditor @CircAHA

3/ Key Findings LDL-C dropped: 73 → 32 mg/dL 💪 Total cholesterol, ApoB, Lp(a) ↓ No significant effect on: plaque volume, coronary physiology  Well-tolerated ✅

1/ 🚨 Cardiac Allograft Vasculopathy Inhibition with Alirocumab: The CAVIAR Trial Tested early after heart transplant to see if alirocumab could slow plaque buildup while safely lowering LDL-C. 🧵👇 #AHA25 #SimPub @CircAHA #OHT #PCSK9 #CAV

#AHA25 In the NOTIFY-PICTURE trial, notification of providers/patients of undergoing non-gated chest CT imaging found to have elevated CAC using an AI algorithm was assoc w/ inc. statin use https://t.co/o4lvlQgkN7 @ATSandhu @Mastrodicasa_MD @FaRodriguezMD @SnehaShahJain

Congrats to my #postdoc Dr. Anamika Gangwar @utswheart on her poster at @AHAMeetings AHA25.

Genome-wide polygenic risk score in premature coronary artery disease in India

Great highlight by @ACCinTouch of our Clinical Practice Statement on #SouthAsian Cardiometabolic Health published in @ASPCardio - Clinical Practice Guidelines For Improving South Asian Cardiometabolic Health - American College of Cardiology

Ethnic Differences in HDL Quantity, Quality, and potential association...

Interesting study in @masala_study linking hepatic fat but not other fat depots to albuminuria in #SouthAsians: Associations of Adiposity with Albuminuria in South Asian... : Journal of the American Society of Nephrology

Nice summary study of #genetic diversity in #SouthAsians: Human genetic diversity across South Asian populations: A... : Medicine

Wow! What a great @utswheart presence at #ASPC2025 in Boston this weekend! Helen Hobbs, Darren McGuire, Spencer Carter, and Ann Marie Navar! Congrats to CV fellow Danh Nguyen, and @UTSWInternalMed residents Jimin Hwang (chief), Gabrielle Schwab, and Khush Kharidia!! So proud!

Great work by @AAgarwalaMD and colleagues on establishing CAC percentiles in #southasians: Sex-Specific Coronary Artery Calcium Percentiles Across South Asian Adults: Combined Analyses From MASALA and DILWALE | JACC: Advances

We congratulate Dr. Joshua Beckman on his Award of Meritorious Achievement from the American Heart Association!

Great to see extension of Lp(a) epidemiology in broad populations in @CircAHA !

Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora with Opening Remarks from @vivek_murthy. Register: https://t.co/tJR7VD8yY4 Panelists: @DrMarthaGulati @rdash L. Palaniappan & A. Mathur

Congrats to @TCUBurnettMed scholar @parminderdeo on his talk @texmed 2025 today on his @SMUDedman Albert Schweitzer Fellowship community engagement project in his own #SouthAsian community in parternship with @utswheart South Asian Heart Program! Congrats!

The documentary film, focusing on the epidemic of heart disease in South Asians, The Brown Heart, is now streaming on @JioHotstar in India, and at https://t.co/RimrS2a409 worldwide. Please watch, help us spread the word, and send your feedback to Drs. Nirmal Joshi and Renu Joshi,

Great summary of #hypertension among #Asian subgroups, esp in the U.S.! Very important topic! Disparities in Hypertension Across Age Spectrum Among Asian American Adults: The Power of Data Disaggregation - American College of Cardiology

It was amazing to work together as a team @utswheart Coppell to launch our first #cardiometabolic health #lifestyle group class today! I partnered with Dr. Parul Sharma, RD, who led the #Food as Medicine for Heart Health class, focused on #SouthAsian cuisine.