The cure for most cases of type 2 diabetes (T2DM) requires fat loss. This thread will discuss research showing restoration of carbohydrate tolerance in those with T2DM through addressing the underlying pathology (ectopic fat) rather than just focusing on symptom management.

I use this platform primarily for discussion and a way for me to formulate, refine, and communicate my beliefs. When I quote someone, it’s because their post raises an idea that deserves a closer look, a rebuttal, or some added context for everyone following along. I don't care

I agree with the push for better precision medicine. I think such a future will be invaluable. But the way NNT is being used in this post is a gross misrepresentation. NNTs for the top 10 drugs come almost entirely from short trials, usually 2 to 5 years, while people live with

Energy surplus is the proximal cause for obesity. Calorie intake is a variable we can manipulate with great precision to cause predictable changes in body mass. The practical utility of CICO is debatable, but the biological mechanisms are well-established.

Editor's note: babies enter ketosis rapidly due to extraordinarily high energy requirements. They require ~100 kcal/kg during the first 6 months of life, which is 2-3 times higher than competitive athletes. About 40% of breast milk calories come from carbohydrates.

I have a hard time believing that poverty is the biggest driver of obesity. Not just because the claim is weak, but because it promotes a kind of learned helplessness where people lack agency because of their circumstances. That mindset is fatalistic, disempowering, and helps no

I used to think this too, but it's based on the false assumption that you can't prove a negative. It doesn't matter whether someone says vaccines cause autism or vaccines do not cause autism. Both are claims that can be empirically investigated. The burden of proof is always on

“Safe” fasting blood glucose: – 1980s: under 140 – 1990s: under 126 – Today: under 100 The science hasn’t changed. The sales targets have.

✨I did my own research✨ like they didn’t just get radicalized by a 12 second video made by someone who failed HS biology🙂‍↕️

I think it's silly that I needed to even clarify this, but so many people in these comments are missing the point. https://t.co/WqeJKAETUU

A lot of people are completely missing my actual point. If you think formal education is biased or useless and you also don’t have that same formal education, then using its absence as an attack against someone else is logically incoherent. You can’t dismiss doctors for having

There's a whole subset of people who will criticize medical doctors like this while they themselves have little to no education on these topics. For some bizarre reason, they think that going to the gym and watching YouTube videos means that they are more knowledgeable.

I really like this study for illustrating the point. It shows that fat cell hypertrophy regardless of fat composition or inflammation invokes insulin resistance. Doesn't matter what causes you to be too fat. Being too fat is itself the proximal cause of insulin resistance in fat

I've never seen a clinical trial of GLP-1 receptor agonists that validates these claims. Most report 20-40% lean mass loss, and this is explained entirely by being sedentary and not eating enough protein.

100%. It’s not the emotions, but how they are expressed. If a man collapses into weakness or uses self victimization language, I need to *man* up myself now. Which flips the polarity. And I can’t trust the man to contain and protect me. It’s really as simple as that.

Editor's note: Long-chain omega-3s like EPA and DHA actively resolve inflammation by making specialized molecules called resolvins and protectins that switch the immune system off once the job’s done. PUFAs can oxidize, sure, but the net effect of omega-3s in humans is lower

There’s a common narrative that high LDL or ApoB is merely a “marker” of poor metabolic health rather than a true cause of heart disease. It’s a seductive idea, but not quite accurate. Let's start with what Tro got right: insulin resistance, chronic inflammation, and metabolic

Editor's note: Heart disease isn’t caused by one thing. It’s the result of many interrelated factors like blood pressure, inflammation, insulin resistance, genetics, and yes, LDL particles. Lowering one causal factor doesn’t erase the others. That’s like saying, “If smoking

Here's a link to my prior post on raw milk food-borne illnesses. https://t.co/1lQJDuqfnn

I wrote about the literature on raw milk safety almost a year ago, which I will link to in a follow-up comment, but I think it is also worth looking at the potential benefits. First, to summarize my prior post, the major routes of milk contamination are environmental

I once again urge everyone to judge people on the basis of their arguments, not on the basis of their credentials. Saying somebody is not a physician to discredit them, as if that has any bearing on their knowledge, is pure appeal to authority.