Alan Boyle
@AP_Boyle
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Genomics/Bioinformatics Assoc. Prof., University of Michigan Msstate, Duke, Stanford, Michigan Genetic Variation, Silencers, RegulomeDB, Nanopore Tech
Ann Arbor, MI
Joined March 2009
RT @hyejung_won: 1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotr….
cell.com
High-throughput experimental validation of genetic variants linked to eight psychiatric disorders reveals the regulatory mechanisms underlying variants with pleiotropic and disorder-specific effects.
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RT @anshulkundaje: Our ChromBPNet preprint out! Huge congrats to @panushri25! This was quite a slog for both of us but we r very proud of….
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RT @UM_MNI: MNI is actively recruiting for 𝙨𝙚𝙫𝙚𝙧𝙖𝙡 𝗳𝗮𝗰𝘂𝗹𝘁𝘆 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀, seeking the best and brightest in #neuroscience to fill these roles.….
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RT @jengreitz: Excited to share the white paper for the IGVF Consortium, supported by @genome_gov . Deciphering the impact of genomic varia….
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RT @connor_maltby: New paper from my postdoc work at @UMichResearch is now out in @ScienceAdvances 🎉 very proud to share the culmination o….
science.org
Functional analysis of human CANVAS neurons reveals a repeat-dependent but RFC1 protein–independent cause of neuronal dysfunction.
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RT @realToddLab: Our first study in a new repeat expansion disorder: CANVAS. @connor_maltby used patient iPSNs to define how this non-ref….
science.org
Functional analysis of human CANVAS neurons reveals a repeat-dependent but RFC1 protein–independent cause of neuronal dysfunction.
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RT @CellPressNews: Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants..
cell.com
McAfee and Lee et al. utilized a massively parallel reporter assay to functionally validate schizophrenia-associated non-coding regulatory variants. Leveraging an accessibility-by-contact model, they...
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RT @connor_maltby: New @AP_Boyle and @realToddLab collaboration is now up on @medrxivpreprint 🥳 we used targeted long read sequencing and H….
medrxiv.org
Tandem repeat sequences comprise approximately 8% of the human genome and are linked to more than 50 neurodegenerative disorders. Accurate characterization of disease-associated repeat loci remains...
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RT @KeisukeMotone: Our preprint is out! We hacked the @nanopore sequencer to read amino acids and PTMs along protein strands. This opens up….
biorxiv.org
The ability to sequence single protein molecules in their native, full-length form would enable a more comprehensive understanding of proteomic diversity. Current technologies, however, are limited...
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RT @hyejung_won: I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. Thi….
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RT @realToddLab: Want to join a fun, supportive, and intellectually curious lab that explores the interface between fundamental mRNA biolog….
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RT @DrAnneCarpenter: US citizens or permanent residents from an under-represented group! High school thru postdoc/faculty. You can contact….
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RT @HGGAdvances: 📢New in @HGGAdvances!.@AP_Boyle & colleagues explore the challenges posed when screening for de novo variants in complex p….
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RT @ryan_e_mills: Really excited to be part of this with @AP_Boyle and @mikemc43! Our part of the project will be focused on exploring soma….
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RT @FreddolinoLab: Happy to share that our Michigan #CASP15 team ended up placing second in Regular Targets, first in Multimeric Targets, a….
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This is some great new work by students in the labs and our collaborators!.
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Determining the mechanisms of radioresistance in breast cancer (PB1072), and Determining the mechanisms of radioresistance in breast cancer (PB3489). And tomorrow our work on Organ-specific prioritization of non-coding regulatory variants with stacking generalization (PB2664).
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