Congrats on your National LMS Foundation award, @priyachudasama5 #ctos2025

Proteomic profiling of >1000 FFPE samples of bone and soft tissue sarcoma revealed B7-H3 expression in all histological subtypes, with heterogeneity of expression within and between subtypes and highest expression in UPS, myxofibrosarcoma, liposarcoma, osteosarcoma #CTOS2025

🚨Historical presentation at #CTOS2025 ChonDRAgon - first positive randomised trial in chondrosarcoma 🔹Ozekibart vs placebo 🔹 mPFS 5.52 vs 2.66 months 🔹 HR 0.479; p<0.0001 🔹 a manageable safety profile - most common TRAE: fatigue, diarrhea, and nausea

Discovery of a dual culprit role that TGF-β has for suppressing the immune response in colon cancer, promoting metastasis (in experimental model) @IRBBarcelona @NatureGenet https://t.co/iIonI5odM7

Longer walks linked with less mortality and cardiovascular risk compared with short bouts of physical activity @AnnalsofIM @uk_biobank https://t.co/DBOFdlm31P

Online Now: TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors https://t.co/UWoB9aRkM3

I wish all spider plots from sarcoma trials would look like the one from the recent update of the DeFi trial leading to regulatory approval of nirogacestat in US and Europe for our patients with desmoid fibromatosis. https://t.co/MFHuEfp4Cx

@NobelPrize The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering how the immune system prevents itself from attacking the body — a process called peripheral immune tolerance. Our immune system defends us from

Our grantees at @MDAndersonNews have uncovered a way to direct the immune system against brachyury, and their discoveries led to NIH funding for a clinical trial set to open next year led by @APConley77. Plus, we and @CancerResearch just co-awarded a new grant to the MD Anderson

European Commission approved vimseltinib for the treatment of adults with symptomatic tenosynovial giant cell tumor not qualifying for surgery and with clinically relevant deterioration of physical function. First drug over here for TGCT: important milestone for European patients

Intresting article in @Nature showed that #metformin led to a markedly lower prevalence of #DNMT3A R822-mutant clonal hematopoiesis #CH 💡Could metofrmin to prevent progression to #AML❓ @OncoAlert #leusm #CHIP #MDS https://t.co/hD3B7nzcqp

Circulating Tumor Cells: Mechanistic drivers of metastasis & biomarker promise 🌊 Intravasation via EMT/VEGF; clusters = 25–50× ↑ metastasis 🔀 Lineage plasticity (epithelial ↔ mesenchymal ↔ neuroendocrine) 🛡️ Platelets & neutrophils shield CTCs; PD-L1+ escape 🧬

TBXT is present in many cancers, especially chordoma, but barely expressed in normal tissue. Aiming to exploit this difference, Cassian Yee and colleagues at @MDAndersonNews have found that TBXT peptides are expressed on MHC receptors and are now developing cell therapies to

DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps https://t.co/Dlhr0YYc74

🚨New paper alert: Today, in @jitcancer, we quantify the rate of baseline HLA loss of heterozygosity across >70,000 patients with common solid cancer types and correlate with overall survival. @MSKCancerCenter @MSK_DeptOfMed @parkerici. #TCellpower #TCRpower

📢New MS out now, where we pair real-world clinical data from patients at @MSKCancerCenter with HLA zygosity derived from #IMPACT to detect HLA loss and its effect on survival, an increasingly important biomarker in the age of immunotherapies.

Importantly, the data generated involved lots of support including @ChordomaFDN @OSInstitute and others. Many more people are involved. Hopefully, the end result will benefit our patients affected with bone sarcomas. @MDAndersonNews

grateful to our group involved w/our new #sarcoma SPORE grant. Under @GorlickRichard & Andy Futreal, we have 2 projects (#chordoma & #osteosarcoma). This involves multiple departments. public link: https://t.co/pt1psG6K9Q. Science: Cassian Yee, Shulin Li, Gorlick, & Futreal

Regular coffee consumption is associated with increased brain white matter integrity & cortical thickness.

Role for Mifamurtide in Primary HG Osteosarcoma? https://t.co/whOkfJjHkQ by @ManuPalmerini @SylvesterCancer & @BrotoJavier @fjimenezdiaz -398 pts -5yr EFS 65%, OS 75% -Mif+Chemo 5yr EFS 71%, OS 75% -Chemo only 5yr EFS 58%, OS 66% -Mif may⬆️ 5yr EFS by 13% & OS by 9% -MVA P=.06