Sub-analysis of the BEST trial showing IVUS-guided PCI equivalent to CABG! An excellent review of the paper by @GreggWStone discussed how we can be better at what we do and be equivalent to bypass. In the order of importance, just in my opinion! 1-Intravscular imaging. A

#PFO device closure can result in LA dysfunction. Measuring baseline #echofirst LA function could help guide closure decisions in cryptogenic #stroke. https://t.co/t5ddyKnaQy #NeuroCardiology #JACCIMG #cvImaging #AFib @de_clinico

LAA patency and PDL identified by CT may be associated with an increased risk of thromboembolism. These findings indicate that residual leaks detected by CT may be clinically significant and should not be regarded as benign.

Provocative study from the RENOVATE trialists and Samsung Med Cntr suggesting use of intravascular imaging may eliminate long-term diffs between CABG & PCI. Not definitive absent a powered RCT, but should be enough to mandate IVI in these pts, esp with class I guidelines. Agree?

#Diastology @JaeKOh2 tips: 1. LVEDP can be ⬆️ with nl mean LV Diastolic pressure 2. #AFib variation in the mitral E velocities c/w nl LVFP. No variation c/w ⬆️LVFP 3. not "normal diastolic function" but “normal diastolic filling pressure” #ASE2018

In patients with cardiometabolic HFpEF, semaglutide and tirzepatide showed more than 40% risk reduction for the composite of hospitalization for heart failure or all-cause mortality compared with a placebo

Among patients who underwent CABG for an acute coronary syndrome, ticagrelor plus aspirin did not result in a lower incidence of death, myocardial infarction, stroke, or repeat coronary revascularization than aspirin alone at 1 year.

#ESC2025 #SimPub: CASTLE-HTx 3-year outcomes: In patients with end-stage heart failure, AF ablation sustained survival & reduced the need for surgical HF therapies over 36 months, with fewer deaths & LVAD/HTx procedures than medical therapy alone. https://t.co/9bEJmD5EN5

Among patients with provoked VTE and enduring risk factors, low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding.

In patients with STEMI with cardiogenic shock, early mechanical support with a microaxial pump reduced the risk of death at 180 days, with the survival benefit persisting up to 10 years despite device-related complications.

Among patients with uncontrolled or resistant hypertension, the addition of baxdrostat to background therapy resulted in a significantly lower seated systolic blood pressure at 12 weeks than placebo.

In addition to lowering Valsalva LVOT gradients and left atrial volume index, treatment with aficamten compared with metoprolol over 24 weeks led to improvement in measures of LV diastolic function, mitral valve SAM, and mitral regurgitation.

These findings add to the evidence that clopidogrel monotherapy is superior to aspirin monotherapy for MACCE prevention with no increase in the risk of bleeding, and support the preferential use of clopidogrel over aspirin for secondary prevention for CAD

The estimated risk of a composite of death, myocardial infarction or heart failure was similar in recipients and non-recipients of ACEi/ARB. Our estimates suggest ACEi/ARB treatment in myocardial infarction with preserved LVEF does not confer a benefit.

The totality of evidence suggests that HFpEF evolves—not as a heterogenous disorder related to diverse comorbidities and not as a primary disorder of cardiomyocytes—but as an adipose-driven derangement

An inclisiran-based treatment strategy was superior to ioLLT in LDL-C goal achievement, delivering early and sustained LDL-C reduction, with fewer MRAEs in individuals with hypercholesterolaemia. cholesterol, muscle-related adverse events, quality of life

Among patients with NSTEMI and multivessel disease, FFR-guided complete revascularization reduced the risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year vs culprit-only revascularization. #ESCCongress #WCCardio https://t.co/CYQYSeEWxT

In other findings, study investigators said immediate complete revascularization was associated with more harm in patients with signs of heart failure than those without.

Among patients without documented atrial arrhythmia recurrence after catheter ablation for AF, discontinuing oral anticoagulant therapy resulted in a lower risk for the composite outcome of stroke, systemic embolism, and major bleeding

Among patients with chronic CS at high atherothrombotic risk who were receiving an oral anticoagulant, the addition of aspirin led to a higher risk of CV death, myocardial infarction, stroke, systemic embolism, coronary revascularization, or death