ZackB
@zacharyberndsen
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Assistant Professor of Biochemistry at the University of Missouri Columbia. MO by way of CA by way of MO.
Columbia, MO
Joined November 2010
Our ApoB paper is out in print today in @Nature and since we didn't get the cover I can share our (@CKeithCassidy ) beautiful artwork from that wasn't selected 😆.
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Hey, I recognize that structure.
🧬 ApoB Conformation and LDL Atherogenicity. 👉This paper delves into how specific conformational changes in apolipoprotein B-100 impact LDL particle behavior — particularly its binding affinity to arterial wall proteoglycans. These structural transitions increase LDL retention
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Brain will live on through the limitless joy his music brings. One of the greatest 💔.
We are heartbroken to announced that our beloved father Brian Wilson has passed away. We are at a loss for words right now. Please respect our privacy at this time as our family grieving. We realize that we are sharing our grief with the world. Love & Mercy
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Parenteral vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization | Infection and Immunity
journals.asm.org
Enterotoxigenic Escherichia coli (ETEC) is a heterogeneous, diarrheagenic pathogenic variant (pathovar) of E. coli, defined by the production of heat-labile and/or heat-stable enterotoxins (1). These...
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Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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RT @buildmodels: April's Molecule of the Month: Apolipoprotein B-100 and LDL Receptor.Insights into how LDL is removed from the bloodstream….
pdb101.rcsb.org
Insights into how LDL is removed from the bloodstream
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RT @demishassabis: Hypothesis generation and testing is a critical capability for AGI imo. Super excited about our AI co-scientist and othe….
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🧐.
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above
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A protein at the heart of heart disease
showme.missouri.edu
Mizzou researchers discover the structure of a protein that could lead to more targeted heart disease treatments.
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"The molecular structure of LDL.has finally been elucidated" - News and Views piece online today in Nature Reviews Cardiology.
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all that work to make a GFP with the same structure that is not as good. the 500M of evolution thing seems like is a slick marketing slogan. If the tech is so great, why not go after a novel function? Maybe I'm missing something.
An #AI model created to design proteins simulates 500 million years of protein evolution in developing a previously unknown bright fluorescent protein. Learn more in a new Science study:
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The structure of bad cholesterol comes into focus . A nice news piece from Nature on our structure and the LDL-r complex structure from @nih_nhlbi !.
nature.com
Nature - High-resolution structures of low-density lipoprotein.
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RT @TzviyaZBM: Thrilled that our atomic model of sperm doublet microtubule is now published .Revealing axoneme ATP regenerating system, anc….
nature.com
Nature - Cryoelectron microscopy, cryoelectron tomography and proteomics are used to resolve the 96-nm modular repeat of axonemal doublet microtubules from both sperm flagella and epithelial cilia...
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RT @buildmodels: Now that AlphaFold has tackled biology’s greatest challenge, scientists can turn to even bigger questions..
magazine.hms.harvard.edu
Now that AlphaFold has tackled biology’s greatest challenge, scientists can turn to even bigger questions
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Cholesterol-wrapping lipoprotein gets a closer look via @cenmag nice article highlighting our recent #apoB structure and the complementary work from the @nih_nhlbi team!.
cen.acs.org
Chemical & Engineering News (C&EN): Keeping you up to date with the chemistry news that matters most. Published by the American Chemical Society.
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Pretty badass actually. If only Walter White had been a virologist and not a chemist, so much drama could have been avoided.
A scientist who successfully treated her own breast cancer by injecting the tumour with lab-grown viruses has sparked discussion about the ethics of self-experimentation.
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