Xin Sui
@xsui98
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Chemical Biology PhD student @ChemistryMIT, @Broadinstitute. Undergraduate @Tsinghua_Uni; #spatialtranscriptomics
California, USA
Joined January 2017
RT @nemo08061: CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such a….
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Check this review on spatial omics!.
Spatial omics technology is transforming our understanding of in situ RNA biology. We are grateful for the opportunity to publish this review in @MolecularCell. We hope this will be a useful resource for the community. @HailingShi @nemo08061 @WangXiaoLab.
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Excited to share Deep-STARmap and Deep-RIBOmap! We enabled spatial transcriptomic and translatomic mapping of >1K genes in 200 µm thick tissue and neuron morphology co-profiling. Thanks @WangXiaoLab for unwavering support; Jennifer for human skin study!
biorxiv.org
Characterizing the transcriptional and translational gene expression patterns at the single-cell level within their three-dimensional (3D) tissue context is essential for revealing how genes shape...
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Excited to share SWITCH-seq, a multiplexed in situ RNA sequencing method that discerns single-base variations in rRNA. Very honored to work with @D_Rothschild_ , and Theo. Thanks, @WangXiaoLab and @mbarnalab for the incredible support and guidance.
1/9.We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
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RT @nemo08061: To fill the gap in cross-sample, cross-technology, and single-cell level spatial analyses, we created CAST to search, match,….
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RT @CellCellPress: Now online! Multimodal charting of molecular and functional cell states via in situ electro-sequencing .
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New way to measure translation!.
RIBOmap for spatially resolved single-cell translatomics is published today! Congrats to the whole team and thanks so much for the constructive feedback and great suggestion from the editor, reviewers, colleagues, and friends! .
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RT @WangXiaoLab: Thrilled to share RIBOmap, a 3D in situ profiling method to detect mRNA translation for thousands of genes simultaneously….
biorxiv.org
The precise control of mRNA translation is a crucial step in post-transcriptional gene regulation of cellular physiology. However, it remains a major challenge to systematically study mRNA translat...
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Thanks!.
In this Graduate Student Spotlight, Xin Sui of Professor Xiao Wang's group shares the most interesting place he’s visited, the bit of trivia he knows that is interesting, yet useless, the most heartwarming thing he’s ever seen, and more:
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RT @ganoopyliujia: Thrilled to share our new preprint @XiaoWan38018817: in situ electro-seq that integrates soft bioelectronics, in situ se….
biorxiv.org
Pairwise mapping of single-cell gene expression and electrophysiology in intact three-dimensional (3D) tissues is crucial for studying electrogenic organs ( e.g. , brain and heart)[1][1]–[5][2]....
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RT @satijalab: I really enjoy reading the first preprints from new labs, esp when they are awesome. Here are 2:. From @kieranrcampbell Anno….
biorxiv.org
Quantifying RNAs in their spatial context is crucial to understanding gene expression and regulation in complex tissues. In situ transcriptomic methods generate spatially resolved RNA profiles in...
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