Yufei Xiang
@xiang_yufei
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Years, lovers and glasses of wine, these are the things that should never be counted.
Joined August 2020
Excited to share our paper on machine learning generative models for designing peptide inhibitors of protein-protein interactions https://t.co/1MRvXE5LIj! A collaboration between Wolfson and Gal labs of Tel Aviv University [1/6] @TelAvivUni @TAD_Tau @PLOSCompBio
journals.plos.org
Author summary Peptides that efficiently bind a target protein and interfere with its native protein-protein interactions are attractive reagents for basic research and therapeutic applications....
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Explore the data now @EMDB_EMPIAR & @PDBeurope
#EMDB: https://t.co/MP744br5eM
#PDBe: https://t.co/fjjgVBLmCd Related: https://t.co/LRnHQz6vZt
#StructuralBiology #SingleParticle #CryoEM #SARSCoV2 #Spike #Virus #Nanobodies #Neutralising #SARSCoV #Omicron #Biology #Science 3/3
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Immune Molecules From a Llama Could Provide Protection Against a Vast Array of SARS-like Viruses Including COVID-19, Researchers Say | Mount Sinai - New York
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Superimmunity by pan-sarbecovirus nanobodies
cell.com
Xiang et al. characterize 100 diverse pan-sarbecovirus nanobodies (psNbs) that are highly effective against SARS-CoV and SARS-CoV-2 variants, including Omicron, with the best median neutralization...
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My fifth visit to the McKittrick Hotel and wonderful experience of #sleepnomore Full of surprises every time 😉😉
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Exciting collaboration with @Proteomics_Shi @KongChen17 @TubianaJerome @xiang_yufei Li Fan and Haim Wolfson integration computation and experiments to understand Omicron mutations! 1/n
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Next-generation #llamaceuticals. Scripps Research’s Prof. Ian Wilson is teaming up with Wally the llama to generate antibodies that are capable of recognizing a wide range of coronaviruses. https://t.co/ydKaSdQEdG
@10News
10news.com
Tiny immune particles derived from a llama named Wally show strong protection against every COVID-19 variant of concern and 18 other sabrecoronaviruses, according to a new study from scientists in...
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https://t.co/JJDLnNyFEZ 1/5 We @xiang_yufei @XXenog discovered “super-immunity” in Llama Wally and rapidly isolated a large repertoire of specific ultrahigh-affinity nanobodies that bind strongly to all known sarbecovirus clades using integrative proteomics.
biorxiv.org
Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies with improved potency and breadth. Here, we observed super-immunity in a camelid extensively immunized with the...
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Save your effort & time for nanobody humanization before preclinical & clinical trials🤗🤗 free online, easy to use. @XXenog Besides, cute-iest software logo! 🥰🥰
Online now! Llamanade: An open-source computational pipeline for robust nanobody humanization
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Online now! Llamanade: An open-source computational pipeline for robust nanobody humanization
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Join this GEN webinar to learn how SARS-CoV-2 Reporter Virus Particles (RVPs, pseudotyped viruses) enable researchers to rapidly test neutralization titers of antibodies and vaccinee sera in a safe BSL-2 environment. Register with the link below! #biotech
https://t.co/HmAFF9L830
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A resource of high-quality and versatile nanobodies for drug delivery
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The labs of Yi Shi @DinaSchneidman Cheng Zhang & Wei Huang present the structures of potent neutralizing nanobodies bound to the receptor binding domain of the SARS-CoV-2 spike protein @Proteomics_Shi @xjtuhw @ChengZh42895446
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Llamanade: an open-source computational pipeline for robust nanobody humanization
biorxiv.org
Nanobodies (Nbs) have recently emerged as a promising class of antibody fragments for biomedical and therapeutic applications. Despite having marked physicochemical properties, Nbs are derived from...
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We found potent neutralizing nanobodies are highly resistant to different SARS-CoV-2 variants and discovered a novel class of nanobodies (III) that can latch on unique and conserved viral epitopes that are likely inaccessible to human antibodies. https://t.co/hHHDd6kneg
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It was real!!!!!!!!!!😭😭😭😭
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APHM, authorities: Stop the harassment of the carriers of scientific speech and integrity- Sign the Petition! https://t.co/CCZMlFznEo via @Change
change.org
Call to stop the harassment of scientific spokespersons & defenders of science integrity
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Thanks to the 435 who have RSVPed. We are almost at capacity, but register for the premiere at 7 p..m tonight. https://t.co/VNINkhfR5W
@EndPolioNow @gatesfoundation New Film ‘Chasing COVID’ Parallels Pitt’s Polio History with Battle Against Coronavirus
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Xiang et al. report a strategy to systematically investigate camelid nanbody repertories. They map and analyse the epitopes of >100,000 antigen-nanobody complexes from immunised llamas and provide insights into the mechanisms of antigen-nanobody binding.
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