Valeria Añorve-Garibay
@valenomics
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Computational Biology PhD student at @BrownCCMB | Huerta-Sánchez lab | BSc Genomics @UNAM_MX | ancient and modern admixture, complex traits | she, her
Joined March 2020
Alessandro and I discussed this great paper https://t.co/XcHv9i8SGJ that investigates a deleterious genetic interaction that causes melanoma.
science.org
A combination of mapping approaches identifies interacting genes that lead to incompatibility and melanoma in natural hybrid fish.
NEW content online! Discovering genetic interactions that cause melanoma in a non-model species
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🇵🇹Our paper on Portugal's genetic history is now published in @GenomeBiology. We present the largest collection of ancient Portuguese genomes, with deeper analyses than our pre-print, revealing migrations, admixture and remarkable continuity https://t.co/RO8vrL4FJw
@TeixeiraJoaoC
genomebiology.biomedcentral.com
Background Recent ancient DNA studies uncovering large-scale demographic events in Iberia have presented very limited data for Portugal, a country located at the westernmost edge of continental...
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Our paper is out! Happy to have collaborated with @mashaals , @emiliahsc and @valenomics on this project. Here we analyzed how stabilizing and directional selection cause problems to predict traits in ancient samples.
The paper is out in @AJHGNews!!! “Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples”. Read it here:
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Our work is out in AJHG "Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples." Great collaboration with @dortega_delv & @emiliahsc, led by talented @lcgejunam undergrad @valenomics, now a PhD student at @BrownCCMB.
The paper is out in @AJHGNews!!! “Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples”. Read it here:
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and endless thanks to @dortega_delv, @mashaals, and @emiliahsc for their support throughout this work!
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The paper is out in @AJHGNews!!! “Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples”. Read it here:
I am stoked to announce that my first first-author preprint is out!! 🎉 https://t.co/z0p6njE42A I started this work as an undergrad student in @dortega_delv lab in collaboration with @mashaals and @emiliahsc. Summary ⬇️
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📣New from Añorve-Garibay et al! 📄Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples https://t.co/B4dVYblv1v
cell.com
Using polygenic scores, we find that two types of natural selection, stabilizing selection and directional selection, can decrease the prediction accuracy of complex traits in ancient individuals. We...
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Honored and humbled to be mentioned for my contributions in human evolutionary genetics. Thanks @emiliahsc for the shout out to our work in this piece highlighting women’s contributions to science. https://t.co/4tdDffeuhK
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Nice collaboration with Luliana Lonita-Laza's group at Columbia. "Fine-mapping in admixed populations using CARMA-X, with applications to Latin American studies" now out in @AJHGNews @scientist_ninja @valenomics
https://t.co/ZOgHU1KbfD
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¡La convocatoria para el ingreso a la Licenciatura en Ciencias Genómicas que se imparte en el Campus Juriquilla de la UNAM ya está disponible! ¡A partir de hoy puedes registrarte para el proceso interno de ingreso y ser parte de la 8ava generación de la #LCGEJ! @lcgejunam 🧬🥼💻
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Dr. @lisatoafault shared so many wisdom pearls! Emilia and Rori share their lessons from this amazing conversation in the new bonus episode, out today! 🎧 https://t.co/naos8MMrfp Listen wherever you get your podcasts!
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Past migrations and environmental exposures have influenced human genomic #diversity; understanding and contextualizing this diversity is crucial to advancing #precisionmedicine & equitable healthcare. Review from @mashaals @ccg_unam
https://t.co/7VmVD6FB6s
nature.com
Nature Medicine - This Perspective explains how past migrations and environmental exposures have influenced genomic diversity, and how understanding and contextualizing this diversity is crucial to...
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Si me dieran a elegir, volvería a ser científica. También volvería a encontrar a las amigas para acompañarnos, aprender y desaprender cosas. Las abrazaría más. Elegiría siempre aprender del mundo y tratar de analizarlo hasta el nivel más pequeño, literalmente.
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Season Two starts NOW! 🚀 Dr. @MEOrive joins us for #WomenInScienceDay and shares her academic journey - from finding her path in science to earning tenure✨ This convo is full of honesty and thoughtful insights! Listen now! 🎧 https://t.co/wJgYWdRvZz
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📢Online now! 📰Genome-wide maps of highly-similar intrachromosomal repeats that can mediate ectopic recombination in three human genome assemblies 🧑🤝🧑@cgonzagaj @CMBCarvalho & colleagues 👉 https://t.co/9ME5oL5qwl
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LIIGH investigator @cgonzagaj and @lcgejunam student Luis Fernandez-Luna in collaboration with investigators from @PNRIGenetics and @bcmhouston just published a new article cataloguing and analyzing highly similar repeated sequences in the human genome @HGGAdvances Read it here👇🏽
📢Online now! 📰Genome-wide maps of highly-similar intrachromosomal repeats that can mediate ectopic recombination in three human genome assemblies 🧑🤝🧑@cgonzagaj @CMBCarvalho & colleagues 👉 https://t.co/9ME5oL5qwl
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I am proud to share our latest paper📜 “The multi-scale complexity of human genetic variation beyond continental groups”, just pre-printed on @biorxivpreprint! Link Here ➡️ https://t.co/eSZHTYyBD6
biorxiv.org
Traditional clustering and visualization approaches in human genetics often operate under frameworks that assume inherent, discrete groupings[1][1],[2][2]. These methods can inadvertently simplify...
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Natural selection can provoke substantial biases in predicting complex traits from ancient genomes using polygenic scores, so it’s crucial to consider its impact when predicting complex traits! 7/7
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In addition, our simulations showed that both types of selection can hamper polygenic scores accuracy for traits like height and BMI, despite having complete genotype data and perfect effect size estimates. 6/7
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